Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Goncharov, Tatiana, Hedayati, Stefanie, Mulvihill, Melinda M., Izrael-Tomasevic, Anita, Zobel, Kerry, Jeet, Surinder, Fedorova, Anna V., Eidenschenk, Celine, deVoss, Jason, Yu, Kebing, Shaw, Andrey S., Kirkpatrick, Donald S., Fairbrother, Wayne J., Deshayes, Kurt, Vucic, Domagoj
Published in Molecular cell (15.02.2018)
Published in Molecular cell (15.02.2018)
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Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis
Laukens, Bram, Jennewein, Claudia, Schenk, Barbara, Vanlangenakker, Nele, Schier, Alexander, Cristofanon, Silvia, Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Jeremias, Irmela, Bertrand, Mathieu J.M, Vandenabeele, Peter, Fulda, Simone
Published in Neoplasia (New York, N.Y.) (01.10.2011)
Published in Neoplasia (New York, N.Y.) (01.10.2011)
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Requirement of Nuclear Factor κB for Smac Mimetic–Mediated Sensitization of Pancreatic Carcinoma Cells for Gemcitabine-Induced Apoptosis
Stadel, Dominic, Cristofanon, Silvia, Abhari, Behnaz Ahangarian, Deshayes, Kurt, Zobel, Kerry, Vucic, Domagoj, Debatin, Klaus-Michael, Fulda, Simone
Published in Neoplasia (New York, N.Y.) (01.12.2011)
Published in Neoplasia (New York, N.Y.) (01.12.2011)
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Journal Article
X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists
Varfolomeev, Eugene, Alicke, Bruno, Elliott, J.Michael, Zobel, Kerry, West, Kristina, Wong, Harvey, Scheer, Justin M., Ashkenazi, Avi, Gould, Stephen E., Fairbrother, Wayne J., Vucic, Domagoj
Published in The Journal of biological chemistry (11.12.2009)
Published in The Journal of biological chemistry (11.12.2009)
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Journal Article
Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists
Ndubaku, Chudi, Varfolomeev, Eugene, Wang, Lan, Zobel, Kerry, Lau, Kevin, Elliott, Linda O, Maurer, Brigitte, Fedorova, Anna V, Dynek, Jasmin N, Koehler, Michael, Hymowitz, Sarah G, Tsui, Vickie, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Vucic, Domagoj
Published in ACS chemical biology (17.07.2009)
Published in ACS chemical biology (17.07.2009)
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Journal Article
Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins
Lee, Erinna F., Fedorova, Anna, Zobel, Kerry, Boyle, Michelle J., Yang, Hong, Perugini, Matthew A., Colman, Peter M., Huang, David C.S., Deshayes, Kurt, Fairlie, W.Douglas
Published in The Journal of biological chemistry (06.11.2009)
Published in The Journal of biological chemistry (06.11.2009)
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Journal Article
c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation
Varfolomeev, Eugene, Goncharov, Tatiana, Fedorova, Anna V., Dynek, Jasmin N., Zobel, Kerry, Deshayes, Kurt, Fairbrother, Wayne J., Vucic, Domagoj
Published in The Journal of biological chemistry (05.09.2008)
Published in The Journal of biological chemistry (05.09.2008)
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Journal Article
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors
Varfolomeev, Eugene, Goncharov, Tatiana, Maecker, Heather, Zobel, Kerry, Kömüves, László G, Deshayes, Kurt, Vucic, Domagoj
Published in Science signaling (20.03.2012)
Published in Science signaling (20.03.2012)
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Journal Article
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
Varfolomeev, Eugene, Blankenship, John W., Wayson, Sarah M., Fedorova, Anna V., Kayagaki, Nobuhiko, Garg, Parie, Zobel, Kerry, Dynek, Jasmin N., Elliott, Linda O., Wallweber, Heidi J.A., Flygare, John A., Fairbrother, Wayne J., Deshayes, Kurt, Dixit, Vishva M., Vucic, Domagoj
Published in Cell (16.11.2007)
Published in Cell (16.11.2007)
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Journal Article
Structure-guided design of a selective BCL-XL inhibitor
Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, Paul, Kersten, Wilhelmus J A, Kulasegaram, Sanji, Moss, Rebecca M, Parisot, John P, Smith, Brian J, Street, Ian P, Yang, Hong, Huang, David C S, Watson, Keith G
Published in Nature chemical biology (01.06.2013)
Published in Nature chemical biology (01.06.2013)
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Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity
Garofalo, Albert W., Schwarz, Jacob, Zobel, Kerry, Beato, Claudia, Bernardi, Silvia, Budassi, Federica, Caberlotto, Laura, Gao, Peng, Griffante, Cristiana, Liu, Xinying, Migliore, Marco, Qiao, Feifei, Sabbatini, Fabio Maria, Sava, Anna, Zhang, Mingliang, Carlisle, Holly J.
Published in Bioorganic & medicinal chemistry letters (15.10.2023)
Published in Bioorganic & medicinal chemistry letters (15.10.2023)
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Journal Article
Selective Inhibitors of G2019S-LRRK2 Kinase Activity
Garofalo, Albert W, Bright, Jessica, De Lombaert, Stéphane, Toda, Alyssa M. A, Zobel, Kerry, Andreotti, Daniele, Beato, Claudia, Bernardi, Silvia, Budassi, Federica, Caberlotto, Laura, Gao, Peng, Griffante, Cristiana, Liu, Xinying, Mengatto, Luisa, Migliore, Marco, Sabbatini, Fabio Maria, Sava, Anna, Serra, Elena, Vincetti, Paolo, Zhang, Mingliang, Carlisle, Holly J
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1 RIP3-dependent reactive oxygen species production
Vanlangenakker, N, Vanden Berghe, T, Bogaert, P, Laukens, B, Zobel, K, Deshayes, K, Vucic, D, Fulda, S, Vandenabeele, P, Bertrand, M J M
Published in Cell death and differentiation (01.04.2011)
Published in Cell death and differentiation (01.04.2011)
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Journal Article
Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
Dueber, Erin C., Schoeffler, Allyn J., Lingel, Andreas, Elliott, J. Michael, Fedorova, Anna V., Giannetti, Anthony M., Zobel, Kerry, Maurer, Brigitte, Varfolomeev, Eugene, Wu, Ping, Wallweber, Heidi J. A., Hymowitz, Sarah G., Deshayes, Kurt, Vucic, Domagoj, Fairbrother, Wayne J.
Published in Science (American Association for the Advancement of Science) (21.10.2011)
Published in Science (American Association for the Advancement of Science) (21.10.2011)
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Journal Article
Origins of PDZ Domain Ligand Specificity
Skelton, Nicholas J., Koehler, Michael F.T., Zobel, Kerry, Wong, Wai Lee, Yeh, Sherry, Pisabarro, M. Theresa, Yin, Jian Ping, Lasky, Laurence A., Sidhu, Sachdev S.
Published in The Journal of biological chemistry (28.02.2003)
Published in The Journal of biological chemistry (28.02.2003)
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Journal Article
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity
Okamoto, Toru, Zobel, Kerry, Fedorova, Anna, Quan, Clifford, Yang, Hong, Fairbrother, Wayne J, Huang, David C. S, Smith, Brian J, Deshayes, Kurt, Czabotar, Peter E
Published in ACS chemical biology (15.02.2013)
Published in ACS chemical biology (15.02.2013)
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Journal Article
Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Journal Article
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)
Blankenship, John W, Varfolomeev, Eugene, Goncharov, Tatiana, Fedorova, Anna V, Kirkpatrick, Donald S, Izrael-Tomasevic, Anita, Phu, Lilian, Arnott, David, Aghajan, Mariam, Zobel, Kerry, Bazan, J Fernando, Fairbrother, Wayne J, Deshayes, Kurt, Vucic, Domagoj
Published in Biochemical journal (01.01.2009)
Published in Biochemical journal (01.01.2009)
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Journal Article
Internal motions prime cIAP1 for rapid activation
Phillips, Aaron H, Schoeffler, Allyn J, Matsui, Tsutomu, Weiss, Thomas M, Blankenship, John W, Zobel, Kerry, Giannetti, Anthony M, Dueber, Erin C, Fairbrother, Wayne J
Published in Nature structural & molecular biology (01.12.2014)
Published in Nature structural & molecular biology (01.12.2014)
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