A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
Znabet, Anass, Polak, Marloes M., Janssen, Elwin, de Kanter, Frans J. J., Turner, Nicholas J., Orru, Romano V. A., Ruijter, Eelco
Published in Chemical communications (Cambridge, England) (14.11.2010)
Published in Chemical communications (Cambridge, England) (14.11.2010)
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Palladium-Catalyzed Synthesis of 4-Aminophthalazin-1(2H)-ones by Isocyanide Insertion
Vlaar, Tjøstil, Ruijter, Eelco, Znabet, Anass, Janssen, Elwin, de Kanter, Frans J. J, Maes, Bert U. W, Orru, Romano V. A
Published in Organic letters (16.12.2011)
Published in Organic letters (16.12.2011)
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Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions
Znabet, Anass, Ruijter, Eelco, de Kanter, Frans J.J, Köhler, Valentin, Helliwell, Madeleine, Turner, Nicholas J, Orru, Romano V.A
Published in Angewandte Chemie (International ed.) (19.07.2010)
Published in Angewandte Chemie (International ed.) (19.07.2010)
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Journal Article
Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines
Köhler, Valentin, Bailey, Kevin R., Znabet, Anass, Raftery, James, Helliwell, Madeleine, Turner, Nicholas J.
Published in Angewandte Chemie (15.03.2010)
Published in Angewandte Chemie (15.03.2010)
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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence
Znabet, Anass, Zonneveld, Job, Janssen, Elwin, De Kanter, Frans J. J., Helliwell, Madeleine, Turner, Nicholas J., Ruijter, Eelco, Orru, Romano V. A.
Published in Chemical communications (Cambridge, England) (07.11.2010)
Published in Chemical communications (Cambridge, England) (07.11.2010)
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Journal Article
Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence
Znabet, Anass, Blanken, Sara, Janssen, Elwin, de Kanter, Frans J. J., Helliwell, Madeleine, Turner, Nicholas J., Ruijter, Eelco, Orru, Romano V. A.
Published in Organic & biomolecular chemistry (07.02.2012)
Published in Organic & biomolecular chemistry (07.02.2012)
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Scope and Limitations of an Efficient Four-Component Reaction for Dihydropyridin-2-ones
Scheffelaar, Rachel, Paravidino, Monica, Znabet, Anass, Schmitz, Rob F, de Kanter, Frans J. J, Lutz, Martin, Spek, Anthony L, Guerra, Célia Fonseca, Bickelhaupt, F. Matthias, Groen, Marinus B, Ruijter, Eelco, Orru, Romano V. A
Published in Journal of organic chemistry (05.03.2010)
Published in Journal of organic chemistry (05.03.2010)
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Stereoselective synthesis of N-aryl proline amides by biotransformationUgi-Smiles sequenceThis work was financially supported by the Netherlands Organization for Scientific Research (NWO) by means of a Mosaic Fellowship to A. Z. We thank Dr M. T. Smoluch (VU University) for HRMS measurements.Electronic supplementary information (ESI) available: Experimental procedures, characterization data and copies of 1H and 13C NMR spectra for all new compounds. CCDC reference number 844264. For ESI and crys
Znabet, Anass, Blanken, Sara, Janssen, Elwin, de Kanter, Frans J. J, Helliwell, Madeleine, Turner, Nicholas J, Ruijter, Eelco, Orru, Romano V. A
Year of Publication 12.01.2012
Year of Publication 12.01.2012
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Journal Article
Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality
Paravidino, Monica, Bon, Robin S, Scheffelaar, Rachel, Vugts, Danielle J, Znabet, Anass, Schmitz, Rob F, de Kanter, Frans J. J, Lutz, Martin, Spek, Anthony L, Groen, Marinus B, Orru, Romano V. A
Published in Organic letters (09.11.2006)
Published in Organic letters (09.11.2006)
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A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactionsElectronic supplementary information (ESI) available: Detailed experimental procedures, characterization data, and copies of 1H and 13C NMR spectra. See DOI: 10.1039/c0cc02823a
Znabet, Anass, Polak, Marloes M, Janssen, Elwin, de Kanter, Frans J. J, Turner, Nicholas J, Orru, Romano V. A, Ruijter, Eelco
Year of Publication 19.10.2010
Year of Publication 19.10.2010
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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequenceElectronic supplementary information (ESI) available: Detailed experimental procedures, characterization data, and copies of 1H and 13C NMR spectra. Crystallographic data for compound 14a. CCDC 786098. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0cc02938f
Znabet, Anass, Zonneveld, Job, Janssen, Elwin, De Kanter, Frans J. J, Helliwell, Madeleine, Turner, Nicholas J, Ruijter, Eelco, Orru, Romano V. A
Year of Publication 12.10.2010
Year of Publication 12.10.2010
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Journal Article
Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions
Znabet, Anass, Ruijter, Eelco, de Kanter, Frans J. J., Köhler, Valentin, Helliwell, Madeleine, Turner, Nicholas J., Orru, Romano V. A.
Published in Angewandte Chemie (19.07.2010)
Published in Angewandte Chemie (19.07.2010)
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Journal Article
Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines
Köhler, Valentin, Bailey, Kevin R., Znabet, Anass, Raftery, James, Helliwell, Madeleine, Turner, Nicholas J.
Published in Angewandte Chemie (15.03.2010)
Published in Angewandte Chemie (15.03.2010)
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Journal Article
Process for the preparation of a-acyloxy ss-formamido amides
RUIJTER EELCO, POLAK MARLOES, TURNER NICHOLAS, ZNABET ANASS, ORRU ROMANO
Year of Publication 20.05.2015
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Year of Publication 20.05.2015
Patent
PROCESS FOR THE PREPARATION OF ALPHA-ACYLOXY BETA-FORMAMIDO AMIDES
RUIJTER EELCO, POLAK MARLOES, TURNER NICHOLAS, ZNABET ANASS, ORRU ROMANO
Year of Publication 31.07.2014
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Year of Publication 31.07.2014
Patent
Process for the preparation of α-acyloxy -formamido amides
RUIJTER EELCO, POLAK MARLOES, TURNER NICHOLAS, ZNABET ANASS, ORRU ROMANO
Year of Publication 01.04.2014
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Year of Publication 01.04.2014
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PROCESS FOR THE PREPARATION OF -ACYLOXY -FORMAMIDO AMIDES
POLAK, MARLOES, ORRU, ROMANO, ZNABET, ANASS, TURNER, NICHOLAS, RUIJTER, EELCO
Year of Publication 02.01.2013
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Year of Publication 02.01.2013
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A PROCESS FOR THE PREPARATION OF SUBSTITUTED PROLYL PEPTIDES AND SIMILAR PEPTIDOMIMETICS
POLAK, MARLOES, ORRU, ROMANO, ZNABET, ANASS, TURNER, NICHOLAS, RUIJTER, EELCO
Year of Publication 02.01.2013
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Year of Publication 02.01.2013
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PROCESS FOR THE PREPARATION OF alpha-ACYLOXY beta-FORMAMIDO AMIDES
RUIJTER EELCO, POLAK MARLOES, TURNER NICHOLAS, ZNABET ANASS, ORRU ROMANO
Year of Publication 27.12.2012
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Year of Publication 27.12.2012
Patent