Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
Gupta, Urvi, Ghosh, Sayan, Wallace, Callen T., Shang, Peng, Xin, Ying, Nair, Archana Padmanabhan, Yazdankhah, Meysam, Strizhakova, Anastasia, Ross, Mark A., Liu, Haitao, Hose, Stacey, Stepicheva, Nadezda A., Chowdhury, Olivia, Nemani, Mihir, Maddipatla, Vishnu, Grebe, Rhonda, Das, Manjula, Lathrop, Kira L., Sahel, José-Alain, Zigler, J. Samuel, Qian, Jiang, Ghosh, Arkasubhra, Sergeev, Yuri, Handa, James T., St. Croix, Claudette M., Sinha, Debasish
Published in Autophagy (02.01.2023)
Published in Autophagy (02.01.2023)
Get full text
Journal Article
The role of lipocalin-2 in age-related macular degeneration (AMD)
Ghosh, Sayan, Stepicheva, Nadezda, Yazdankhah, Meysam, Shang, Peng, Watson, Alan M., Hose, Stacey, Liu, Haitao, Weiss, Joseph, Zigler, J. Samuel, Valapala, Mallika, Watkins, Simon C., Sinha, Debasish
Published in Cellular and molecular life sciences : CMLS (01.03.2020)
Published in Cellular and molecular life sciences : CMLS (01.03.2020)
Get full text
Journal Article
Role of glia in optic nerve
Yazdankhah, Meysam, Shang, Peng, Ghosh, Sayan, Hose, Stacey, Liu, Haitao, Weiss, Joseph, Fitting, Christopher S., Bhutto, Imran A., Zigler, J. Samuel, Qian, Jiang, Sahel, José-Alain, Sinha, Debasish, Stepicheva, Nadezda A.
Published in Progress in retinal and eye research (01.03.2021)
Published in Progress in retinal and eye research (01.03.2021)
Get full text
Journal Article
A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration
Ghosh, Sayan, Shang, Peng, Terasaki, Hiroto, Stepicheva, Nadezda, Hose, Stacey, Yazdankhah, Meysam, Weiss, Joseph, Sakamoto, Taiji, Bhutto, Imran A, Xia, Shuli, Zigler, Jr, J Samuel, Kannan, Ram, Qian, Jiang, Handa, James T, Sinha, Debasish
Published in Investigative ophthalmology & visual science (20.03.2018)
Published in Investigative ophthalmology & visual science (20.03.2018)
Get full text
Journal Article
Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
Sinha, Debasish, Valapala, Mallika, Shang, Peng, Hose, Stacey, Grebe, Rhonda, Lutty, Gerard A., Zigler, J. Samuel, Kaarniranta, Kai, Handa, James T.
Published in Experimental eye research (01.03.2016)
Published in Experimental eye research (01.03.2016)
Get full text
Journal Article
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
Yazdankhah, Meysam, Ghosh, Sayan, Shang, Peng, Stepicheva, Nadezda, Hose, Stacey, Liu, Haitao, Chamling, Xitiz, Tian, Shenghe, Sullivan, Mara L.G., Calderon, Michael Joseph, Fitting, Christopher S., Weiss, Joseph, Jayagopal, Ashwath, Handa, James T., Sahel, José-Alain, Zigler, J. Samuel, Kinchington, Paul R., Zack, Donald J., Sinha, Debasish
Published in Autophagy (03.10.2021)
Published in Autophagy (03.10.2021)
Get full text
Journal Article
Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy
Liu, Haitao, Stepicheva, Nadezda A., Ghosh, Sayan, Shang, Peng, Chowdhury, Olivia, Daley, Rachel A., Yazdankhah, Meysam, Gupta, Urvi, Hose, Stacey L., Valapala, Mallika, Fitting, Christopher Scott, Strizhakova, Anastasia, Shan, Yang, Feenstra, Derrick, Sahel, José-Alain, Jayagopal, Ashwath, Handa, James T., Zigler, J. Samuel, Fort, Patrice E., Sodhi, Akrit, Sinha, Debasish
Published in Nature communications (13.10.2022)
Published in Nature communications (13.10.2022)
Get full text
Journal Article
A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems
Zigler, Jr, J Samuel, Hodgkinson, Colin A, Wright, Megan, Klise, Andrew, Sundin, Olof, Broman, Karl W, Hejtmancik, Fielding, Huang, Hao, Patek, Bonnie, Sergeev, Yuri, Hose, Stacey, Brayton, Cory, Xaiodong, Jiao, Vasquez, David, Maragakis, Nicholas, Mori, Susumu, Goldman, David, Hoke, Ahmet, Sinha, Debasish
Published in PloS one (29.07.2016)
Published in PloS one (29.07.2016)
Get full text
Journal Article
Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy
Liu, Haitao, Ghosh, Sayan, Vaidya, Tanuja, Bammidi, Sridhar, Huang, Chao, Shang, Peng, Nair, Archana Padmanabhan, Chowdhury, Olivia, Stepicheva, Nadezda A, Strizhakova, Anastasia, Hose, Stacey, Mitrousis, Nikolaos, Gadde, Santosh Gopikrishna, Mb, Thirumalesh, Strassburger, Pamela, Widmer, Gabriella, Lad, Eleonora M, Fort, Patrice E, Sahel, José-Alain, Zigler, Jr, J Samuel, Sethu, Swaminathan, Westenskow, Peter D, Proia, Alan D, Sodhi, Akrit, Ghosh, Arkasubhra, Feenstra, Derrick, Sinha, Debasish
Published in JCI insight (22.06.2023)
Published in JCI insight (22.06.2023)
Get full text
Journal Article
Activating the AKT2–nuclear factor‐κB–lipocalin‐2 axis elicits an inflammatory response in age‐related macular degeneration
Ghosh, Sayan, Shang, Peng, Yazdankhah, Meysam, Bhutto, Imran, Hose, Stacey, Montezuma, Sandra R, Luo, Tianqi, Chattopadhyay, Sreya, Qian, Jiang, Lutty, Gerard A, Ferrington, Deborah A, Zigler, Jr, J Samuel, Sinha, Debasish
Published in The Journal of pathology (01.04.2017)
Published in The Journal of pathology (01.04.2017)
Get full text
Journal Article
Primary Cell Cultures from the Mouse Retinal Pigment Epithelium
Shang, Peng, Stepicheva, Nadezda A, Hose, Stacey, Zigler, Jr, J Samuel, Sinha, Debasish
Published in Journal of visualized experiments (16.03.2018)
Published in Journal of visualized experiments (16.03.2018)
Get full text
Journal Article
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish
Published in Autophagy (01.03.2014)
Published in Autophagy (01.03.2014)
Get full text
Journal Article
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
Zigler, J. Samuel Jr, Zhang, Cheng, Grebe, Rhonda, Sehrawat, Gitanjali, Hackler, Laszlo Jr, Adhya, Souvonik, Hose, Stacey, McLeod, D. Scott, Bhutto, Imran, Barbour, Walid, Parthasarathy, Geetha, Zack, Donald J, Sergeev, Yuri, Lutty, Gerard A, Handa, James T, Sinha, Debasish
Published in Journal of cell science (15.02.2011)
Published in Journal of cell science (15.02.2011)
Get full text
Journal Article
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
Shang, Peng, Stepicheva, Nadezda, Teel, Kenneth, McCauley, Austin, Fitting, Christopher Scott, Hose, Stacey, Grebe, Rhonda, Yazdankhah, Meysam, Ghosh, Sayan, Liu, Haitao, Strizhakova, Anastasia, Weiss, Joseph, Bhutto, Imran A., Lutty, Gerard A., Jayagopal, Ashwath, Qian, Jiang, Sahel, José-Alain, Samuel Zigler, J., Handa, James T., Sergeev, Yuri, Rajala, Raju V. S., Watkins, Simon, Sinha, Debasish
Published in Communications biology (08.07.2021)
Published in Communications biology (08.07.2021)
Get full text
Journal Article
A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD
Shang, Peng, Stepicheva, Nadezda A, Liu, Haitao, Chowdhury, Olivia, Franks, Jonathan, Sun, Ming, Hose, Stacey, Ghosh, Sayan, Yazdankhah, Meysam, Strizhakova, Anastasia, Stolz, Donna Beer, Zigler, Jr, J Samuel, Sinha, Debasish
Published in International journal of molecular sciences (05.11.2021)
Published in International journal of molecular sciences (05.11.2021)
Get full text
Journal Article
Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy
Daley, Rachel, Maddipatla, Vishnu, Ghosh, Sayan, Chowdhury, Olivia, Hose, Stacey, Zigler, J. Samuel, Sinha, Debasish, Liu, Haitao
Published in Cell death discovery (13.07.2023)
Published in Cell death discovery (13.07.2023)
Get full text
Journal Article
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling
Shang, Peng, Valapala, Mallika, Grebe, Rhonda, Hose, Stacey, Ghosh, Sayan, Bhutto, Imran A., Handa, James T., Lutty, Gerard A., Lu, Lixia, Wan, Jun, Qian, Jiang, Sergeev, Yuri, Puertollano, Rosa, Zigler, J. Samuel, Xu, Guo‐Tong, Sinha, Debasish
Published in Aging cell (01.04.2017)
Published in Aging cell (01.04.2017)
Get full text
Journal Article
Mitophagy in Astrocytes Is Required for the Health of Optic Nerve
Yazdankhah, Meysam, Ghosh, Sayan, Liu, Haitao, Hose, Stacey, Zigler, Jr, J Samuel, Sinha, Debasish
Published in Cells (Basel, Switzerland) (01.10.2023)
Published in Cells (Basel, Switzerland) (01.10.2023)
Get full text
Journal Article