Approach to de-risk structural alerts in compound progression
Rotter, Charles, Estrella, Heather, Takafumi, Takai, Zhu, Sean
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Get full text
Journal Article
Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice
Woloshun, Regina R., Yu, Yang, Xu, Xiaodong, Lee, Jennifer K., Zhu, Sean, Shine, Jacob S., Ebea, Pearl, Stevens, Bruce R., Vidyasagar, Sadasivan, Collins, James F.
Published in Blood advances (24.05.2022)
Published in Blood advances (24.05.2022)
Get full text
Journal Article
Metabolism and Excretion of [ 14 C]Mobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects
Chen, Hao, Shah, Abhi, Kato, Suguru, Griffin, Robert, Zhang, Steven, Pusalkar, Sandeepraj, Cohen, Lawrence, Li, Yuexian, Chowdhury, Swapan K, Zhu, Sean Xiaochun
Published in Drug metabolism and disposition (01.10.2024)
Published in Drug metabolism and disposition (01.10.2024)
Get full text
Journal Article
Metabolism and Excretion of 14CMobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects
Chen, Hao, Shah, Abhi, Kato, Suguru, Griffin, Robert, Zhang, Steven, Pusalkar, Sandeepraj, Cohen, Lawrence, Li, Yuexian, Chowdhury, Swapan K, Zhu, Sean Xiaochun
Published in Drug metabolism and disposition (16.09.2024)
Published in Drug metabolism and disposition (16.09.2024)
Get full text
Journal Article
A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of 14C-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants
Hanley, Michael J, Zhang, Steven, Griffin, Robert, Zhu, Sean Xiaochun, Fram, Robert J, Lin, Jianchang, Venkatakrishnan, Karthik, Gupta, Neeraj
Published in Investigational new drugs (01.08.2024)
Published in Investigational new drugs (01.08.2024)
Get full text
Journal Article
Chronic pelvic pain in an interdisciplinary setting: 1-year prospective cohort
Allaire, Catherine, Williams, Christina, Bodmer-Roy, Sonja, Zhu, Sean, Arion, Kristina, Ambacher, Kristin, Wu, Jessica, Yosef, Ali, Wong, Fontayne, Noga, Heather, Britnell, Susannah, Yager, Holly, Bedaiwy, Mohamed A., Albert, Arianne Y., Lisonkova, Sarka, Yong, Paul J.
Published in American journal of obstetrics and gynecology (01.01.2018)
Published in American journal of obstetrics and gynecology (01.01.2018)
Get full text
Journal Article
A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [14C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants
Hanley, Michael J., Zhang, Steven, Griffin, Robert, Zhu, Sean Xiaochun, Fram, Robert J., Lin, Jianchang, Venkatakrishnan, Karthik, Gupta, Neeraj
Published in Investigational new drugs (01.08.2024)
Published in Investigational new drugs (01.08.2024)
Get full text
Journal Article
Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24‐hydroxylase inhibitor soticlestat in healthy volunteers
Yin, Wei, Ballard, T. Eric, Zhu, Sean Xiaochun, Hsiao, Samuel, Chen, Hao, Li, Yuexian, Chowdhury, Swapan K., Stevenson, Annette, Hui, Tom, Hunt, Allen, Asgharnejad, Mahnaz, Han, Steve
Published in British journal of clinical pharmacology (01.02.2024)
Published in British journal of clinical pharmacology (01.02.2024)
Get full text
Journal Article
Establishing Dietary Iron Requirements for Mouse and Rat Models of Hereditary Hemochromatosis
Lee, Jennifer K, Yu, Yang, DeLellis, Regina R, Ebea, Pearl, Zhu, Sean, Theophilus, Rufus, Collins, James F
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
Get more information
Journal Article
Intestinal Dmt1 is Required for Iron Loading in Mice Modeling β-Thalassemia Intermedia
Yu, Yang, Yang, Chunhua, Shine, Jacob S, Lee, Jennifer K, Ebea, Pearl, Zhu, Sean, Merlin, Didier, Collins, James F
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
Get more information
Journal Article
Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations
He, Minxia Michelle, Zhu, Sean Xiaochun, Cannon, Joe R., Christensen, Jesper Kammersgaard, Duggal, Ruchia, Gunduz, Mithat, Hilgendorf, Constanze, Hughes, Adam, Kekessie, Ivy, Kullmann, Maximilian, Leung, Dennis, Terjung, Carsten, Wang, Kai, Wesche, Frank
Published in Drug metabolism and disposition (01.11.2023)
Published in Drug metabolism and disposition (01.11.2023)
Get full text
Journal Article
Fetal factors disrupt placental and maternal iron homeostasis in murine β-thalassemia
Yu, Yang, Woloshun, Regina R., Lee, Jennifer K., Ebea, Pearl Onuwa, Zhu, Sean, Nemeth, Elizabeta, Garrick, Laura M., Garrick, Michael D., Collins, James F.
Published in Blood (13.07.2023)
Published in Blood (13.07.2023)
Get full text
Journal Article
The Current State of Biotransformation Science – Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends
Savaryn, John P., Coe, Kevin, Cerny, Matthew A., Colizza, Kevin, Moliner, Patricia, King, Lloyd, Ma, Bin, Atherton, Jim, Auclair, Adam, Cancilla, Mark T., Eno, Marsha, Jurva, Ulrik, Yue, Qin, Zhu, Sean Xiaochun, Freiberger, Elyse, Zhong, Guo, Barlock, Ben, Nachtigall, Jonny, Laboureur, Laurent, Pusalkar, Sandeepraj, Guo, Runcong, Niehues, Michael, Hauri, Simon, Carreras, Ester Tor, Maurer, Christine, Prakash, Chandra, Jenkins, Gary J.
Published in Pharmaceutical research (04.11.2024)
Published in Pharmaceutical research (04.11.2024)
Get full text
Journal Article
P11-019-23 An Optimized Amino Acid Formulation Stimulates Iron Absorption in Iron-Deficient Mice and Membrane Localization of DMT1 in Caco-2 Cells
Ebea, Pearl, Lee, Jennifer, He, Yue, Shine, Jacob, Zhu, Sean, Yu, Yang, Vidyasagar, Sadasivan, Collins, James
Published in Current developments in nutrition (01.07.2023)
Published in Current developments in nutrition (01.07.2023)
Get full text
Journal Article
Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma
Rong, Haojing, Sharma, Kirti, Csibi, Fred, Yang, Bin, Rusin, Scott, Shi, Yatao, Dey, Joyoti, Karnik, Rahul, Mayo, Michele, Yuan, Karen, Chutake, Yogesh, McDonald, Alice, Zhu, Sean, Ji, Nan, Liu, Phillip, Li, Henry, Walker, Duncan, Gollob, Jared, Mainolfi, Nello, Desavi, Chris
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
Get full text
Journal Article
Abstract LB037: E3 pairing and structural mechanisms underlying anti-tumor activity of clinical STAT3 degrader KT-333
Sharma, Kirti, Fei, Xue, Shi, Yatao, Browne, Christopher, Walther, Dirk, Daigle, Caroline, Ramanathan, Anand, Miller, Richard, Yuan, Karen, Mahasenan, Kiran, Zhu, Sean, Huang, Xin, Yang, Bin
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Get full text
Journal Article
Prospective Cohort of Deep Dyspareunia in an Interdisciplinary Setting
Yong, Paul J., Williams, Christina, Bodmer-Roy, Sonja, Ezeigwe, Chukwuemeka, Zhu, Sean, Arion, Kristina, Ambacher, Kristin, Yosef, Ali, Wong, Fontayne, Noga, Heather, Britnell, Susannah, Yager, Holly, Bedaiwy, Mohamed A., Brotto, Lori A., Albert, Arianne Y., Lisonkova, Sarka, Allaire, Catherine
Published in Journal of sexual medicine (01.12.2018)
Published in Journal of sexual medicine (01.12.2018)
Get full text
Journal Article
Abstract LB-088: A STAT3 selective targeted protein degrader decreases the immunesuppressive tumor microenvironment and drives antitumor activity in preclinical models
Csibi, Alfredo, Yang, Bin, Chutake, Yogesh, Yuan, Karen, Mayo, Michele, Campbell, Veronica, McDonald, Alice, Rusin, Scott, Sharma, Kirti, Kamadurai, Hari, Li, Henry, Sintchak, Mike, Zhu, Sean, Townson, Sharon, Slavin, Anthony, Rong, Haojing, Liu, Phillip, De Savi, Chris, Gollob, Jared, Walker, Duncan, Ji, Nan, Mainolfi, Nello
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article