Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations
Tao, Hongrui, Yan, Xue, Zhu, Kongkai, Zhang, Hua
Published in Chemical & pharmaceutical bulletin (01.04.2019)
Published in Chemical & pharmaceutical bulletin (01.04.2019)
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Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED–EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations
Zhu, Kongkai, Du, Daohai, Yang, Rui, Tao, Hongrui, Zhang, Hua
Published in Chemical & pharmaceutical bulletin (01.01.2020)
Published in Chemical & pharmaceutical bulletin (01.01.2020)
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Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase
Zhang, Jie, Liu, Hongchuan, Zhu, Kongkai, Gong, Shouzhe, Dramsi, Shaynoor, Wang, Ya-Ting, Li, Jiafei, Chen, Feifei, Zhang, Ruihan, Zhou, Lu, Lan, Lefu, Jiang, Hualiang, Schneewind, Olaf, Luo, Cheng, Yang, Cai-Guang
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization
Mao, Ruifeng, Shao, Jingwei, Zhu, Kongkai, Zhang, Yuanyuan, Ding, Hong, Zhang, Chenhua, Shi, Zhe, Jiang, Hualiang, Sun, Dequn, Duan, Wenhu, Luo, Cheng
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
Yang, Feifei, Zhao, Na, Song, Jiali, Zhu, Kongkai, Jiang, Cheng-Shi, Shan, Peipei, Zhang, Hua
Published in Molecules (Basel, Switzerland) (15.07.2019)
Published in Molecules (Basel, Switzerland) (15.07.2019)
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Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations
Zhu, Kongkai, Jiang, Chengshi, Tao, Hongrui, Liu, Jingqiu, Zhang, Hua, Luo, Cheng
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2
Kong, Xiangqian, Chen, Limin, Jiao, Lianying, Jiang, Xiangrui, Lian, Fulin, Lu, Junyan, Zhu, Kongkai, Du, Daohai, Liu, Jingqiu, Ding, Hong, Zhang, Naixia, Shen, Jingshan, Zheng, Mingyue, Chen, Kaixian, Liu, Xin, Jiang, Hualiang, Luo, Cheng
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Cytochalasins from coastal saline soil-derived fungus Aspergillus flavipes RD-13 and their cytotoxicities
Miao, Shuang, Liu, Mengshan, Qi, Shizhou, Wu, Yan, Sun, Kunlai, Zhang, Zhen, Zhu, Kongkai, Cai, Guowei, Gong, Kaikai
Published in Journal of antibiotics (01.07.2022)
Published in Journal of antibiotics (01.07.2022)
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Arginine Methyltransferase 5 (PRMT5) Inhibitors with 3-(1H-benzo[d]imidazol- 2-yl)anilines Core Identified by Virtual Screening and Biological Evaluation
Zhang, Ying, Zhu, Kongkai, Zhang, Juan, Zhang, Jin-He, Song, Zhiling, Zhang, Xinlei, Liu, Shan-Kui, Jiang, Cheng-Shi
Published in Current pharmaceutical design (01.01.2023)
Published in Current pharmaceutical design (01.01.2023)
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Current Strategies and Applications for Precision Drug Design
Wang, Chen, Xu, Pan, Zhang, Luyu, Huang, Jing, Zhu, Kongkai, Luo, Cheng
Published in Frontiers in pharmacology (18.07.2018)
Published in Frontiers in pharmacology (18.07.2018)
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Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening
Meng, Fanwang, Cheng, Sufang, Ding, Hong, Liu, Shien, Liu, Yan, Zhu, Kongkai, Chen, Shijie, Lu, Junyan, Xie, Yiqian, Li, Linjuan, Liu, Rongfeng, Shi, Zhe, Zhou, Yu, Liu, Yu-Chih, Zheng, Mingyue, Jiang, Hualiang, Lu, Wencong, Liu, Hong, Luo, Cheng
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy
Jiang, Cheng-Shi, Zhuang, Chun-Lin, Zhu, Kongkai, Zhang, Juan, Muehlmann, Luis Alexandre, Figueiró Longo, João Paulo, Azevedo, Ricardo Bentes, Zhang, Wen, Meng, Ning, Zhang, Hua
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2018)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2018)
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Ligand recognition and G protein coupling of the human itch receptor MRGPRX1
Guo, Lulu, Zhang, Yumu, Fang, Guoxing, Tie, Lu, Zhuang, Yuming, Xue, Chenyang, Liu, Qi, Zhang, Minghui, Zhu, Kongkai, You, Chongzhao, Xu, Peiyu, Yuan, Qingning, Zhang, Chao, Liu, Lei, Rong, Naikang, Peng, Shengxuan, Liu, Yuan, Wang, Chuanzheng, Luo, Xin, Lv, Zongyao, Kang, Dongwei, Yu, Xiao, Zhang, Cheng, Jiang, Yi, Dong, Xinzhong, Zhou, Jiuyao, Liu, Zhongmin, Yang, Fan, Eric Xu, H., Sun, Jin-Peng
Published in Nature communications (17.08.2023)
Published in Nature communications (17.08.2023)
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Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Wang, Yin-Yin, Tao, Hong-Rui, Zhu, Kongkai, Zhang, Hua
Published in Molecules (Basel, Switzerland) (15.07.2019)
Published in Molecules (Basel, Switzerland) (15.07.2019)
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Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
Zhu, Kongkai, Song, Jia-Li, Tao, Hong-Rui, Cheng, Zhi-Qiang, Jiang, Cheng-Shi, Zhang, Hua
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Synthesis and biological evaluation of quinoline/cinnamic acid hybrids as amyloid-beta aggregation inhibitors
Ge, Yong-Xi, Cheng, Zhi-Qiang, Zhou, Lei, Xie, Hong-Xu, Wang, Yin-Yin, Zhu, Kongkai, Jiao, Yang, Liu, Guangpu, Jiang, Cheng-Shi
Published in Monatshefte für Chemie (01.05.2020)
Published in Monatshefte für Chemie (01.05.2020)
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Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
Liu, Shan-Kui, Hao, Haifang, Bian, Yuan, Ge, Yong-Xi, Lu, Shengyuan, Xie, Hong-Xu, Wang, Kai-Ming, Tao, Hongrui, Yuan, Chao, Zhang, Juan, Zhang, Jie, Jiang, Cheng-Shi, Zhu, Kongkai
Published in Frontiers in chemistry (08.03.2021)
Published in Frontiers in chemistry (08.03.2021)
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Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Song, Jia-Li, Wang, Yin-Yin, Zhu, Kongkai, Zhang, Hua
Published in Journal of computer-aided molecular design (01.05.2019)
Published in Journal of computer-aided molecular design (01.05.2019)
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Cell membrane-targeting NIR fluorescent probes with large Stokes shifts for ultralong-term transplanted neural stem cell tracking
Chen, Jing, Li, Dan, Li, Hongfu, Zhu, Kongkai, Shi, Leilei, Fu, Xuemei
Published in Frontiers in bioengineering and biotechnology (09.02.2023)
Published in Frontiers in bioengineering and biotechnology (09.02.2023)
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