An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist
Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H, Pitts, William J, Dyckman, Alaric J, Carter, Percy H, Mathur, Arvind, Zhang, Huiping
Published in Organic process research & development (20.05.2016)
Published in Organic process research & development (20.05.2016)
Get full text
Journal Article
An Effective Procedure for the Acylation of Azaindoles at C-3
Zhang, Zhongxing, Yang, Zhong, Wong, Henry, Zhu, Juliang, Meanwell, Nicholas A, Kadow, John F, Wang, Tao
Published in Journal of organic chemistry (23.08.2002)
Published in Journal of organic chemistry (23.08.2002)
Get full text
Journal Article
(+)-Dinapsoline: An Efficient Synthesis and Pharmacological Profile of a Novel Dopamine Agonist
Sit, Sing-Yuen, Xie, Kai, Jacutin-Porte, Swanee, Taber, Matthew T, Gulwadi, Amit G, Korpinen, Carolyn D, Burris, Kevin D, Molski, Thaddeus F, Ryan, Elaine, Xu, Cen, Wong, Henry, Zhu, Juliang, Krishnananthan, Subramaniam, Gao, Qi, Verdoorn, Todd, Johnson, Graham
Published in Journal of medicinal chemistry (15.08.2002)
Published in Journal of medicinal chemistry (15.08.2002)
Get full text
Journal Article
Design, Synthesis, and SAR of C‑3 Benzoic Acid, C‑17 Triterpenoid Derivatives. Identification of the HIV‑1 Maturation Inhibitor 4‑((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)‑3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro‑1H‑cyclopenta[a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
Regueiro-Ren, Alicia, Swidorski, Jacob J., Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L., Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R., Arora, Vinod, Huang, Xiaohua S., Rahematpura, Sandhya, Parker, Dawn D., Haskell, Roy, Santone, Kenneth S., Cockett, Mark I., Krystal, Mark, Meanwell, Nicholas A., Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B.
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
Get full text
Journal Article
Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol
Tai-Shun, Lin, Schinazi, Raymond F., Zhu, Juliang, Birks, Evelyn, Carbone, Rocco, Yikang, Si, Kemei, Wu, Liang, Huang, Prusoff, William H.
Published in Biochemical pharmacology (20.07.1993)
Published in Biochemical pharmacology (20.07.1993)
Get full text
Journal Article
An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P(1) Receptor Agonist
Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H., Pitts, William J., Dyckman, Alaric J., Carter, Percy H., Mathur, Arvind, Zhang, Huiping
Published in Organic process research & development (01.05.2016)
Published in Organic process research & development (01.05.2016)
Get full text
Journal Article
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors
Zhuo, Xiaoliang, Wang, Ying-Zi, Yeung, Kap-Sun, Zhu, Juliang, Huang, Xiaohua Stella, Parcella, Kyle E., Eastman, Kyle J., Kadow, John F., Meanwell, Nicholas A., Shu, Yue-Zhong, Johnson, Benjamin M.
Published in Xenobiotica (02.12.2018)
Published in Xenobiotica (02.12.2018)
Get full text
Journal Article
Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 6. Preclinical and Human Pharmacokinetic Profiling of BMS-663749, a Phosphonooxymethyl Prodrug of the HIV-1 Attachment Inhibitor 2-(4-Benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)
Kadow, John F, Ueda, Yasutsugu, Meanwell, Nicholas A, Connolly, Timothy P, Wang, Tao, Chen, Chung-Pin, Yeung, Kap-Sun, Zhu, Juliang, Bender, John A, Yang, Zhong, Parker, Dawn, Lin, Pin-Fang, Colonno, Richard J, Mathew, Marina, Morgan, Daniel, Zheng, Ming, Chien, Caly, Grasela, Dennis
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
Get full text
Journal Article
Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity
Regueiro-Ren, Alicia, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Beno, Brett R, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Hanumegowda, Umesh, Dicker, Ira B
Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
Get full text
Journal Article
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
Regueiro-Ren, Alicia, Swidorski, Jacob J, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R, Arora, Vinod, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
Get full text
Journal Article
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
Parcella, Kyle, Eastman, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Liu, Mengping, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F
Published in ACS medicinal chemistry letters (13.07.2017)
Published in ACS medicinal chemistry letters (13.07.2017)
Get full text
Journal Article
An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P 1 Receptor Agonist
Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H., Pitts, William J., Dyckman, Alaric J., Carter, Percy H., Mathur, Arvind, Zhang, Huiping
Published in Organic process research & development (20.05.2016)
Published in Organic process research & development (20.05.2016)
Get full text
Journal Article
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase
Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Published in MedChemComm (01.04.2017)
Published in MedChemComm (01.04.2017)
Get full text
Journal Article
Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors
Yeung, Kap-Sun, Beno, Brett R, Mosure, Kathy, Zhu, Juliang, Grant-Young, Katherine A, Parcella, Kyle, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Wang, Ying-Kai, Fang, Hua, Krause, Rudolph, Rigat, Karen, Liu, Mengping, Lemm, Julie, Sheriff, Steven, Witmer, Mark, Tredup, Jeffrey, Jardel, Adam, Kish, Kevin, Parker, Dawn, Haskell, Roy, Santone, Kenneth, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
Get full text
Journal Article
면역조정제로서 유용한 1,3-디히드록시-페닐 유도체
YEUNG KAP SUN, ZHU JULIANG, SAULNIER MARK G, GRANT YOUNG KATHARINE A, SCOLA PAUL MICHAEL, MENG ZHAOXING, FRENNESSON DAVID B
Year of Publication 13.03.2019
Get full text
Year of Publication 13.03.2019
Patent
Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Get full text
Journal Article
Identification of 1-{2-[4-chloro-1 '-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4 '-piperidine]-1-yl] phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Get full text
Journal Article