Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)
Zhi, Yanle, Wang, Zhijie, Yao, Chao, Li, Baoquan, Heng, Hao, Cai, Jiongheng, Xiang, Li, Wang, Yue, Lu, Tao, Lu, Shuai
Published in International journal of molecular sciences (15.11.2019)
Published in International journal of molecular sciences (15.11.2019)
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Journal Article
Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of β,γ‑Unsaturated α‑Ketoesters
Zhi, Yanle, Huang, Jianhang, Liu, Na, Lu, Tao, Dou, Xiaowei
Published in Organic letters (05.05.2017)
Published in Organic letters (05.05.2017)
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Journal Article
Discovery of 4‑((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)‑N‑(4-((4-methylpiperazin-1-yl)methyl)phenyl)‑1H‑pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia
Wang, Yue, Zhi, Yanle, Jin, Qiaomei, Lu, Shuai, Lin, Guowu, Yuan, Haoliang, Yang, Taotao, Wang, Zhanwei, Yao, Chao, Ling, Jun, Guo, Hao, Li, Tonghui, Jin, Jianlin, Li, Baoquan, Zhang, Li, Chen, Yadong, Lu, Tao
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Discovery of Benzo[cd]indol-2(1H)‑ones and Pyrrolo[4,3,2-de]quinolin-2(1H)‑ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis
Jiang, Fei, Hu, Qinghua, Zhang, Zhimin, Li, Hongmei, Li, Huili, Zhang, Dewei, Li, Hanwen, Ma, Yu, Xu, Jingjing, Chen, Haifang, Cui, Yong, Zhi, Yanle, Zhang, Yanmin, Xu, Junyu, Zhu, Jiapeng, Lu, Tao, Chen, Yadong
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Journal Article
Rhodium(I)‐Catalyzed Arylation/Dehydroxylation of tert‐Propargylic Alcohols Leading to Tetrasubstituted Allenes
Liu, Na, Zhi, Yanle, Yao, Jian, Xing, Junhao, Lu, Tao, Dou, Xiaowei
Published in Advanced synthesis & catalysis (15.02.2018)
Published in Advanced synthesis & catalysis (15.02.2018)
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Journal Article
Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor
Zhi, Yanle, Li, Hongmei, Yang, Pei, Jin, Qiaomei, Yao, Chao, Li, Baoquan, Ling, Jun, Guo, Hao, Li, Tonghui, Jin, Jianlin, Wang, Yue, Chen, Yadong, Lu, Tao, Lu, Shuai
Published in European journal of medicinal chemistry (05.08.2023)
Published in European journal of medicinal chemistry (05.08.2023)
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Journal Article
Discovery of the selective and efficacious inhibitors of FLT3 mutations
Zhi, Yanle, Li, Baoquan, Yao, Chao, Li, Hongmei, Chen, Puzhou, Bao, Jiyin, Qin, Tianren, Wang, Yue, Lu, Tao, Lu, Shuai
Published in European journal of medicinal chemistry (15.07.2018)
Published in European journal of medicinal chemistry (15.07.2018)
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Journal Article
Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation
Zhi, Yanle, Wang, Shu, Huang, Wenhai, Zeng, Shenxin, Liang, Meihao, Zhang, Chixiao, Ma, Zhen, Wang, Zunyuan, Zhang, Zhimin, Shen, Zhengrong
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors
Bao, Jiyin, Liu, Haichun, Zhi, Yanle, Yang, Wenqianzi, Zhang, Jiawei, Lu, Tao, Wang, Yue, Lu, Shuai
Published in Bioorganic chemistry (01.01.2020)
Published in Bioorganic chemistry (01.01.2020)
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Journal Article
Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors
Zhang, Li, Zhang, Beichen, Zhao, Jingyun, Zhi, Yanle, Wang, Lu, Lu, Tao, Chen, Yadong
Published in European journal of medicinal chemistry (29.09.2017)
Published in European journal of medicinal chemistry (29.09.2017)
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Journal Article
Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation
Heng, Hao, Zhi, Yanle, Yuan, Haoliang, Wang, Zhijie, Li, Hongmei, Wang, Shuxian, Tian, Jieyi, Liu, Haichun, Chen, Yadong, Lu, Tao, Ran, Ting, Lu, Shuai
Published in European journal of medicinal chemistry (01.02.2019)
Published in European journal of medicinal chemistry (01.02.2019)
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Journal Article
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors
Zhang, Zhimin, Hou, Shaohua, Chen, Hongli, Ran, Ting, Jiang, Fei, Bian, Yuanyuan, Zhang, Dewei, Zhi, Yanle, Wang, Lu, Zhang, Li, Li, Hongmei, Zhang, Yanmin, Tang, Weifang, Lu, Tao, Chen, Yadong
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
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Journal Article
Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance
Wang, Lu, Zhang, Qing, Zhu, Gaoyuan, Zhang, Zhimin, Zhi, Yanle, Zhang, Li, Mao, Tianxiao, Zhou, Xiang, Chen, Yadong, Lu, Tao, Tang, Weifang
Published in European journal of medicinal chemistry (21.04.2017)
Published in European journal of medicinal chemistry (21.04.2017)
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Journal Article
Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model
Heng, Hao, Wang, Zhijie, Li, Hongmei, Huang, Yatian, Lan, Qingyuan, Guo, Xiaoxing, Zhang, Liang, Zhi, Yanle, Cai, Jiongheng, Qin, Tianren, Xiang, Li, Wang, Shuxian, Chen, Yadong, Lu, Tao, Lu, Shuai
Published in European journal of medicinal chemistry (15.08.2019)
Published in European journal of medicinal chemistry (15.08.2019)
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Journal Article
Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1 H -pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors
Zhang, Li, Zhang, Beichen, Zhao, Jingyun, Zhi, Yanle, Wang, Lu, Lu, Tao, Chen, Yadong
Published in European journal of medicinal chemistry (01.09.2017)
Published in European journal of medicinal chemistry (01.09.2017)
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Journal Article
Discovery of 4-((7 H -Pyrrolo[2,3- d ]pyrimidin-4-yl)amino)- N -(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1 H -pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia
Wang, Yue, Zhi, Yanle, Jin, Qiaomei, Lu, Shuai, Lin, Guowu, Yuan, Haoliang, Yang, Taotao, Wang, Zhanwei, Yao, Chao, Ling, Jun, Guo, Hao, Li, Tonghui, Jin, Jianlin, Li, Baoquan, Zhang, Li, Chen, Yadong, Lu, Tao
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1 H -Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)
Zhi, Yanle, Wang, Zhijie, Yao, Chao, Li, Baoquan, Heng, Hao, Cai, Jiongheng, Xiang, Li, Wang, Yue, Lu, Tao, Lu, Shuai
Published in International journal of molecular sciences (15.11.2019)
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Published in International journal of molecular sciences (15.11.2019)
Journal Article
Preparation method and application of gemmarane sesquiterpenoids with hypoglycemic activity
XUE GUIMIN, ZHAO CHENGUANG, ZHAO ZHENZHU, CHEN HUI, ZHI YANLE, XUE JINFENG, SUN YANJUN
Year of Publication 18.10.2022
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Year of Publication 18.10.2022
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