Protein tyrosine phosphatases as potential therapeutic targets
He, Rong-Jun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Zhang, Zhong-Yin
Published in Acta pharmacologica Sinica (01.10.2014)
Published in Acta pharmacologica Sinica (01.10.2014)
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Therapeutic Targeting of Oncogenic Tyrosine Phosphatases
Frankson, Rochelle, Yu, Zhi-Hong, Bai, Yunpeng, Li, Qinglin, Zhang, Ruo-Yu, Zhang, Zhong-Yin
Published in Cancer research (Chicago, Ill.) (01.11.2017)
Published in Cancer research (Chicago, Ill.) (01.11.2017)
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Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling
Zhang, Zhong-Yin, Dodd, Garron T, Tiganis, Tony
Published in Trends in pharmacological sciences (Regular ed.) (01.10.2015)
Published in Trends in pharmacological sciences (Regular ed.) (01.10.2015)
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PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
Wiede, Florian, Lu, Kun‐Hui, Du, Xin, Liang, Shuwei, Hochheiser, Katharina, Dodd, Garron T, Goh, Pei K, Kearney, Conor, Meyran, Deborah, Beavis, Paul A, Henderson, Melissa A, Park, Simone L, Waithman, Jason, Zhang, Sheng, Zhang, Zhong‐Yin, Oliaro, Jane, Gebhardt, Thomas, Darcy, Phillip K, Tiganis, Tony
Published in The EMBO journal (15.01.2020)
Published in The EMBO journal (15.01.2020)
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SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
Chen, Hao, Libring, Sarah, Ruddraraju, Kasi Viswanatharaju, Miao, Jinmin, Solorio, Luis, Zhang, Zhong-Yin, Wendt, Michael K
Published in Oncogene (03.12.2020)
Published in Oncogene (03.12.2020)
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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Zhu, Guangya, Xie, Jingjing, Kong, Wenna, Xie, Jingfei, Li, Yichen, Du, Lin, Zheng, Qiangang, Sun, Lin, Guan, Mingfeng, Li, Huan, Zhu, Tianxin, He, Hao, Liu, Zhenying, Xia, Xi, Kan, Chen, Tao, Youqi, Shen, Hong C., Li, Dan, Wang, Siying, Yu, Yongguo, Yu, Zhi-Hong, Zhang, Zhong-Yin, Liu, Cong, Zhu, Jidong
Published in Cell (15.10.2020)
Published in Cell (15.10.2020)
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Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy
Dong, Jiajun, Miao, Jinmin, Miao, Yiming, Qu, Zihan, Zhang, Sheng, Zhu, Peipei, Wiede, Florian, Jassim, Brenson A., Bai, Yunpeng, Nguyen, Quyen, Lin, Jianping, Chen, Lan, Tiganis, Tony, Tao, W. Andy, Zhang, Zhong‐Yin
Published in Angewandte Chemie International Edition (22.05.2023)
Published in Angewandte Chemie International Edition (22.05.2023)
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Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases
Hamerman, Jessica A., Pottle, Jessica, Ni, Minjian, He, Yantao, Zhang, Zhong-Yin, Buckner, Jane H.
Published in Immunological reviews (01.01.2016)
Published in Immunological reviews (01.01.2016)
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Small molecule tools for functional interrogation of protein tyrosine phosphatases
He, Rongjun, Zeng, Li‐Fan, He, Yantao, Zhang, Sheng, Zhang, Zhong‐Yin
Published in The FEBS journal (01.01.2013)
Published in The FEBS journal (01.01.2013)
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Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Bunda, Severa, Burrell, Kelly, Heir, Pardeep, Zeng, Lifan, Alamsahebpour, Amir, Kano, Yoshihito, Raught, Brian, Zhang, Zhong-Yin, Zadeh, Gelareh, Ohh, Michael
Published in Nature communications (30.11.2015)
Published in Nature communications (30.11.2015)
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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
Zehender, Ariella, Huang, Jingang, Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Trinh-Minh, Thuong, Xu, Xiaohan, Li, Yi-Nan, Chen, Chih-Wei, Lin, Jianping, Dees, Clara, Beyer, Christian, Gelse, Kolja, Zhang, Zhong-Yin, Bergmann, Christina, Ramming, Andreas, Birchmeier, Walter, Distler, Oliver, Schett, Georg, Distler, Jörg H W
Published in Nature communications (14.08.2018)
Published in Nature communications (14.08.2018)
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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B, Radulovich, Nikolina, Poon, Betty P K, St-Germain, Jonathan, Cook, Jonathan D, Valencia-Sama, Ivette, Grant, Benjamin M M, Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S, Lee, Jeffrey E, Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael
Published in Nature communications (15.01.2019)
Published in Nature communications (15.01.2019)
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Insulin regulates POMC neuronal plasticity to control glucose metabolism
Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony
Published in eLife (19.09.2018)
Published in eLife (19.09.2018)
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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Dodd, Garron T., Decherf, Stephanie, Loh, Kim, Simonds, Stephanie E., Wiede, Florian, Balland, Eglantine, Merry, Troy L., Münzberg, Heike, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony
Published in Cell (15.01.2015)
Published in Cell (15.01.2015)
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Quinic Acid‐Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins
Xu, Jun, Lee, Steve Seung‐Young, Seo, Howon, Pang, Liang, Jun, Yearin, Zhang, Ruo‐Yu, Zhang, Zhong‐Yin, Kim, Pilhan, Lee, Wooin, Kron, Stephen J., Yeo, Yoon
Published in Small (Weinheim an der Bergstrasse, Germany) (01.12.2018)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.12.2018)
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Gebregiworgis, Teklab, Kano, Yoshihito, St-Germain, Jonathan, Radulovich, Nikolina, Udaskin, Molly L, Mentes, Ahmet, Huang, Richard, Poon, Betty P K, He, Wenguang, Valencia-Sama, Ivette, Robinson, Claire M, Huestis, Melissa, Miao, Jinmin, Yeh, Jen Jen, Zhang, Zhong-Yin, Irwin, Meredith S, Lee, Jeffrey E, Tsao, Ming-Sound, Raught, Brian, Marshall, Christopher B, Ohh, Michael, Ikura, Mitsuhiko
Published in Nature communications (01.11.2021)
Published in Nature communications (01.11.2021)
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