Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRAS(G12C)
Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Journal Article
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C
Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Niedbala, Michael J, Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M, Ross, Sarah, Sanders, Matthew G, Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
Get full text
Journal Article
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C
Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
Get full text
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