On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation
Brown, Benjamin P, Zhang, Yun-Kai, Westover, David, Yan, Yingjun, Qiao, Huan, Huang, Vincent, Du, Zhenfang, Smith, Jarrod A, Ross, Jeffrey S, Miller, Vincent A, Ali, Siraj, Bazhenova, Lyudmila, Schrock, Alexa B, Meiler, Jens, Lovly, Christine M
Published in Clinical cancer research (01.06.2019)
Published in Clinical cancer research (01.06.2019)
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Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting
Du, Zhenfang, Brown, Benjamin P, Kim, Soyeon, Ferguson, Donna, Pavlick, Dean C, Jayakumaran, Gowtham, Benayed, Ryma, Gallant, Jean-Nicolas, Zhang, Yun-Kai, Yan, Yingjun, Red-Brewer, Monica, Ali, Siraj M, Schrock, Alexa B, Zehir, Ahmet, Ladanyi, Marc, Smith, Adam W, Meiler, Jens, Lovly, Christine M
Published in Nature communications (02.03.2021)
Published in Nature communications (02.03.2021)
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Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo
Zhang, Guan-Nan, Zhang, Yun-Kai, Wang, Yi-Jun, Gupta, Pranav, Ashby, Charles R., Alqahtani, Saeed, Deng, Tongjin, Bates, Susan E., Kaddoumi, Amal, Wurpel, John N.D., Lei, Yi-Xiong, Chen, Zhe-Sheng
Published in Cancer letters (28.06.2018)
Published in Cancer letters (28.06.2018)
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Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study
Wang, Yi-Jun, Zhang, Yun-Kai, Zhang, Guan-Nan, Al Rihani, Sweilem B, Wei, Meng-Ning, Gupta, Pranav, Zhang, Xiao-Yu, Shukla, Suneet, Ambudkar, Suresh V, Kaddoumi, Amal, Shi, Zhi, Chen, Zhe-Sheng
Published in Cancer letters (28.06.2017)
Published in Cancer letters (28.06.2017)
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Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
Brown, Benjamin P., Zhang, Yun-Kai, Kim, Soyeon, Finneran, Patrick, Yan, Yingjun, Du, Zhenfang, Kim, Jiyoon, Hartzler, Abigail Leigh, LeNoue-Newton, Michele L., Smith, Adam W., Meiler, Jens, Lovly, Christine M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2022)
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Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells
Gupta, Pranav, Zhang, Yun-Kai, Zhang, Xiao-Yu, Wang, Yi-Jun, Lu, Kimberly W., Hall, Timothy, Peng, Richard, Yang, Dong-Hua, Xie, Ni, Chen, Zhe-Sheng
Published in Cellular physiology and biochemistry (01.01.2018)
Published in Cellular physiology and biochemistry (01.01.2018)
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Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer
Zhang, Yun-Kai, Wang, Yi-Jun, Lei, Zi-Ning, Zhang, Guan-Nan, Zhang, Xiao-Yu, Wang, De-shen, Al-Rihani, Sweilem B., Shukla, Suneet, Ambudkar, Suresh V., Kaddoumi, Amal, Shi, Zhi, Chen, Zhe-Sheng
Published in Cancer letters (01.02.2019)
Published in Cancer letters (01.02.2019)
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Theoretical study of blue‐green iridium(III) complexes with low‐efficiency roll‐off properties for application in phosphorescent organic light‐emitting diodes
Chi, Hao‐Yuan, Ji, Ye, Zhang, Yun‐Kai, Zhao, Xue‐Ming, Qu, Shao‐Jun, Jiang, Fang‐Da, Lu, Chang‐Hai, Xiao, Bo, Song, Ming‐Xing, Li, Dong‐Fei
Published in Applied organometallic chemistry (01.02.2024)
Published in Applied organometallic chemistry (01.02.2024)
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An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms
Zeng, Leli, Li, Jia, Zhang, Chen, Zhang, Yun-Kai, Zhang, Wei, Huang, Juanjuan, Ashby, Charles R, Chen, Zhe-Sheng, Chao, Hui
Published in Chemical communications (Cambridge, England) (26.03.2019)
Published in Chemical communications (Cambridge, England) (26.03.2019)
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A theory study based on DFT/TD‐DFT for a series of Ir(III) complexes with the low‐efficiency roll‐off and the high‐inter‐system crossover rate properties
Song, Ming‐Xing, Guo, Xi‐Lian, Ji, Ye, Yang, Jia‐Yu, Zhang, Yun‐Kai, Pan, Zi‐Cong, Wang, Mei‐Qi, Qin, Zheng‐Kun
Published in International journal of quantum chemistry (05.01.2024)
Published in International journal of quantum chemistry (05.01.2024)
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In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1
Zhang, Hui, Patel, Atish, Ma, Shao‐Lin, Li, Xiao Jie, Zhang, Yun‐Kai, Yang, Pei‐Qi, Kathawala, Rishil J, Wang, Yi‐Jun, Anreddy, Nagaraju, Fu, Li‐Wu, Chen, Zhe‐Sheng
Published in British journal of pharmacology (01.12.2014)
Published in British journal of pharmacology (01.12.2014)
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Theoretical study on luminescence properties of a series of iridium complexes with high spin orbit coupling coefficients
Qin, Zheng‐Kun, Yang, Jia‐Yu, Guo, Xi‐Lian, Ji, Ye, Zhang, Yun‐Kai, Pan, Zi‐Cong, Wang, Mei‐Qi, Song, Ming‐Xing
Published in Journal of physical organic chemistry (01.10.2023)
Published in Journal of physical organic chemistry (01.10.2023)
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Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters
Zhang, Yun-Kai, Zhang, Guan-Nan, Wang, Yi-Jun, Patel, Bhargav A, Talele, Tanaji T, Yang, Dong-Hua, Chen, Zhe-Sheng
Published in Scientific reports (09.05.2016)
Published in Scientific reports (09.05.2016)
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Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells
Zhang, Xiao-Yu, Zhang, Yun-Kai, Wang, Yi-Jun, Gupta, Pranav, Zeng, Leli, Xu, Megan, Wang, Xiu-Qi, Yang, Dong-Hua, Chen, Zhe-Sheng
Published in Molecules (Basel, Switzerland) (15.09.2016)
Published in Molecules (Basel, Switzerland) (15.09.2016)
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The reversal of antineoplastic drug resistance in cancer cells by β‐elemene
Zhang, Guan‐Nan, Ashby, Charles R., Zhang, Yun‐Kai, Chen, Zhe‐Sheng, Guo, Huiqin
Published in Ai zheng (14.09.2015)
Published in Ai zheng (14.09.2015)
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The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Zhang, Hui, Patel, Atish, Wang, Yi-Jun, Zhang, Yun-Kai, Kathawala, Rishil J, Qiu, Long-Hui, Patel, Bhargav A, Huang, Li-Hua, Shukla, Suneet, Yang, Dong-Hua, Ambudkar, Suresh V, Fu, Li-Wu, Chen, Zhe-Sheng
Published in Molecular cancer therapeutics (01.06.2017)
Published in Molecular cancer therapeutics (01.06.2017)
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Editorial: Targeted cancer therapies, from small molecules to antibodies, volume II
Su, Chao-Yue, Yan, Yan-Yan, Zhang, Jian-Ye, Zhang, Yun-Kai, Chen, Zhe-Sheng
Published in Frontiers in pharmacology (30.06.2023)
Published in Frontiers in pharmacology (30.06.2023)
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Multidrug Resistance Proteins (MRPs) and Cancer Therapy
Zhang, Yun-Kai, Wang, Yi-Jun, Gupta, Pranav, Chen, Zhe-Sheng
Published in The AAPS journal (04.04.2015)
Published in The AAPS journal (04.04.2015)
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Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells
Huang, Xiao-Cong, Xiao, Xue, Zhang, Yun-Kai, Talele, Tanaji T, Salim, Angela A, Chen, Zhe-Sheng, Capon, Robert J
Published in Marine drugs (27.06.2014)
Published in Marine drugs (27.06.2014)
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Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors
Zhang, Zhi-Hua, Zeng, Bi-Fan, Song, Zhe-Xue, Yang, Ying-Yu, Zhang, Kai-yun, Du, Xue, Zhang, Lin-lin, Cai, Dong
Published in Medicinal chemistry research (01.11.2022)
Published in Medicinal chemistry research (01.11.2022)
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