Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
Ramsden, Diane, Perloff, Elke S, Whitcher-Johnstone, Andrea, Ho, Thuy, Patel, Reena, Kozminski, Kirk D, Fullenwider, Cody L, Zhang, J George
Published in Drug metabolism and disposition (01.02.2022)
Published in Drug metabolism and disposition (01.02.2022)
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HUMAN CYTOCHROME P450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE H152/81
ZHANG, J. George, DEHAL, Shangara S, HO, Thuy, JOHNSON, Jennifer, CHANDLER, Catherine, BLANCHARD, Andrew P, CLARK, Robert J, CRESPI, Charles L, STRESSER, David M, WONG, James
Published in Drug metabolism and disposition (01.05.2006)
Published in Drug metabolism and disposition (01.05.2006)
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Development of an in-vitro method as a tool to assess UDP-glucuronyltransferase (UGT) 2B10 Inhibition
Creegan, Tim, Jacob, Lisa, Singh, Ritu, Zhang, J. George
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Evaluation of calibration curve-based approaches to predict clinical inducers and noninducers of CYP3A4 with plated human hepatocytes
Zhang, J George, Ho, Thuy, Callendrello, Alanna L, Clark, Robert J, Santone, Elizabeth A, Kinsman, Sarah, Xiao, Deqing, Fox, Lisa G, Einolf, Heidi J, Stresser, David M
Published in Drug metabolism and disposition (01.09.2014)
Published in Drug metabolism and disposition (01.09.2014)
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Reversible and time-dependent inhibition (TDI) of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in human hepatocyte suspensions by model inhibitors
Zhang, J. George, Ho, Thuy, Patel, Reena, Trisdale, Sarah K., Creegan, Tim, Stresser, David M.
Published in Drug metabolism and pharmacokinetics (01.01.2017)
Published in Drug metabolism and pharmacokinetics (01.01.2017)
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Validation of cocktail enzyme assay in 96-well plated human hepatocytes for CYP1A2, CYP2B6 and CYP3A4 induction studies with LC–MS/MS analysis
Choughule, Kankika V., Ho, Thuy, Wang, Duan, Stresser, David M., Trisdale, Sarah K., Creegan, Tim, Singh, Ritu, Zhang, J. George
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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