Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
Wang, Chao, Fan, Li, Khawaja, Rabia R, Liu, Bangyan, Zhan, Lihong, Kodama, Lay, Chin, Marcus, Li, Yaqiao, Le, David, Zhou, Yungui, Condello, Carlo, Grinberg, Lea T, Seeley, William W, Miller, Bruce L, Mok, Sue-Ann, Gestwicki, Jason E, Cuervo, Ana Maria, Luo, Wenjie, Gan, Li
Published in Nature communications (12.04.2022)
Published in Nature communications (12.04.2022)
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Microglial microRNAs mediate sex-specific responses to tau pathology
Kodama, Lay, Guzman, Elmer, Etchegaray, Jon I, Li, Yaqiao, Sayed, Faten A, Zhou, Lu, Zhou, Yungui, Zhan, Lihong, Le, David, Udeochu, Joe C, Clelland, Claire D, Cheng, Zuolin, Yu, Guoqiang, Li, Qingyun, Kosik, Kenneth S, Gan, Li
Published in Nature neuroscience (01.02.2020)
Published in Nature neuroscience (01.02.2020)
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Journal Article
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
Sayed, Faten A., Telpoukhovskaia, Maria, Kodama, Lay, Li, Yaqiao, Zhou, Yungui, Le, David, Hauduc, Axel, Ludwig, Connor, Gao, Fuying, Clelland, Claire, Zhan, Lihong, Cooper, Yonatan A., Davalos, Dimitrios, Akassoglou, Katerina, Coppola, Giovanni, Gan, Li
Published in Proceedings of the National Academy of Sciences - PNAS (02.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (02.10.2018)
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Journal Article
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Dräger, Nina M, Sattler, Sydney M, Huang, Cindy Tzu-Ling, Teter, Olivia M, Leng, Kun, Hashemi, Sayed Hadi, Hong, Jason, Aviles, Giovanni, Clelland, Claire D, Zhan, Lihong, Udeochu, Joe C, Kodama, Lay, Singleton, Andrew B, Nalls, Mike A, Ichida, Justin, Ward, Michael E, Faghri, Faraz, Gan, Li, Kampmann, Martin
Published in Nature neuroscience (01.09.2022)
Published in Nature neuroscience (01.09.2022)
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Journal Article
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain
Zhan, Lihong, Krabbe, Grietje, Du, Fei, Jones, Ian, Reichert, Meredith C, Telpoukhovskaia, Maria, Kodama, Lay, Wang, Chao, Cho, Seo-Hyun, Sayed, Faten, Li, Yaqiao, Le, David, Zhou, Yungui, Shen, Yin, West, Brian, Gan, Li
Published in PLoS biology (08.02.2019)
Published in PLoS biology (08.02.2019)
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Journal Article
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain
Zhan, Lihong, Fan, Li, Kodama, Lay, Sohn, Peter Dongmin, Wong, Man Ying, Mousa, Gergey Alzaem, Zhou, Yungui, Li, Yaqiao, Gan, Li
Published in eLife (15.10.2020)
Published in eLife (15.10.2020)
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Journal Article
Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS
Kim, Sang Hwa, Stiles, Shannon G, Feichtmeier, Joseph M, Ramesh, Nandini, Zhan, Lihong, Scalf, Mark A, Smith, Lloyd M, Pandey, Udai Bhan, Tibbetts, Randal S
Published in Human molecular genetics (15.01.2018)
Published in Human molecular genetics (15.01.2018)
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Journal Article
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
Telpoukhovskaia, Maria A, Liu, Kai, Sayed, Faten A, Etchegaray, Jon Iker, Xie, Min, Zhan, Lihong, Li, Yaqiao, Zhou, Yungui, Le, David, Bahr, Ben A, Bogyo, Matthew, Ding, Sheng, Gan, Li
Published in Scientific reports (13.08.2020)
Published in Scientific reports (13.08.2020)
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Journal Article
Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability
Shanware, Naval P., Hutchinson, John A., Kim, Sang Hwa, Zhan, Lihong, Bowler, Michael J., Tibbetts, Randal S.
Published in The Journal of biological chemistry (08.04.2011)
Published in The Journal of biological chemistry (08.04.2011)
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Journal Article
Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila
Zhan, Lihong, Hanson, Keith A, Kim, Sang Hwa, Tare, Apeksha, Tibbetts, Randal S
Published in PloS one (27.02.2013)
Published in PloS one (27.02.2013)
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Journal Article
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models
van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I, Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E, Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M, Beumers, Philipp, Capell, Anja, Davis, Sonnet S, de Weerd, Lis, Dugas, Jason C, Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T, Kunze, Lea H, Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O, Nguyen, Hoang N, Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H, Thorne, Robert G, Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y Joy Yu, Diaz, Dolo, Dennis, Mark S, Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J, Haass, Christian, Lewcock, Joseph W, Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E, Monroe, Kathryn M
Published in Nature neuroscience (01.03.2023)
Published in Nature neuroscience (01.03.2023)
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Journal Article
Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
Krabbe, Grietje, Minami, S. Sakura, Etchegaray, Jon I., Taneja, Praveen, Djukic, Biljana, Davalos, Dimitrios, Le, David, Lo, Iris, Zhan, Lihong, Reichert, Meredith C., Sayed, Faten, Merlini, Mario, Ward, Michael E., Perry, David C., Lee, Suzee E., Sias, Ana, Parkhurst, Christopher N., Gan, Wen-biao, Akassoglou, Katerina, Miller, Bruce L., Farese, Robert V., Gan, Li
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2017)
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Journal Article
Crystal structure of GnsA from Escherichia coli
Wei, Yong, Zhan, Lihong, Gao, Zengqiang, Privé, Gilbert G., Dong, Yuhui
Published in Biochemical and biophysical research communications (19.06.2015)
Published in Biochemical and biophysical research communications (19.06.2015)
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Journal Article
HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
Summer, Heike, Li, Ou, Bao, Qiuye, Zhan, Lihong, Peter, Sabrina, Sathiyanathan, Padmapriya, Henderson, Dana, Klonisch, Thomas, Goodman, Steven D, Dröge, Peter
Published in Nucleic acids research (01.07.2009)
Published in Nucleic acids research (01.07.2009)
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Journal Article
A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING
Clelland, Claire, Etchegaray, J. Iker, Kodama, Lay, Sayed, Faten, Sachdev, Aradhana, Li, Yaqiao, Le, David, Zhan, Lihong, Zhou, Yungui, Duong, Duc, Seyfried, Nicholas T., Kukar, Thomas G., Tan, Li Xuan, Lakkaraju, Aparna, Conklin, Bruce, Gan, Li
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P4‐511: A NOVEL ROLE FOR THE FTD‐CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING
Clelland, Claire, Etchegaray, J. Iker, Kodama, Lay, Sayed, Faten, Sachdev, Aradhana, Li, Yaqiao, Le, David, Zhan, Lihong, Zhou, Yungui, Duong, Duc, Seyfried, Nicholas T., Kukar, Thomas G., Tan, Li Xuan, Lakkaraju, Aparna, Conklin, Bruce, Gan, Li
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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