Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana
Published in Aging cell (01.02.2021)
Published in Aging cell (01.02.2021)
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Journal Article
The bystander effect contributes to the accumulation of senescent cells in vivo
Silva, Paulo F. L., Ogrodnik, Mikolaj, Kucheryavenko, Olena, Glibert, Julien, Miwa, Satomi, Cameron, Kerry, Ishaq, Abbas, Saretzki, Gabriele, Nagaraja‐Grellscheid, Sushma, Nelson, Glyn, Zglinicki, Thomas
Published in Aging cell (01.02.2019)
Published in Aging cell (01.02.2019)
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Journal Article
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
Lagnado, Anthony, Leslie, Jack, Ruchaud‐Sparagano, Marie‐Helene, Victorelli, Stella, Hirsova, Petra, Ogrodnik, Mikolaj, Collins, Amy L, Vizioli, Maria Grazia, Habiballa, Leena, Saretzki, Gabriele, Evans, Shane A, Salmonowicz, Hanna, Hruby, Adam, Geh, Daniel, Pavelko, Kevin D, Dolan, David, Reeves, Helen L, Grellscheid, Sushma, Wilson, Colin H, Pandanaboyana, Sanjay, Doolittle, Madison, von Zglinicki, Thomas, Oakley, Fiona, Gallage, Suchira, Wilson, Caroline L, Birch, Jodie, Carroll, Bernadette, Chapman, James, Heikenwalder, Mathias, Neretti, Nicola, Khosla, Sundeep, Masuda, Claudio Akio, Tchkonia, Tamar, Kirkland, James L, Jurk, Diana, Mann, Derek A, Passos, João F
Published in The EMBO journal (03.05.2021)
Published in The EMBO journal (03.05.2021)
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Mitochondrial dysfunction in cell senescence and aging
Miwa, Satomi, Kashyap, Sonu, Chini, Eduardo, von Zglinicki, Thomas
Published in The Journal of clinical investigation (01.07.2022)
Published in The Journal of clinical investigation (01.07.2022)
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Journal Article
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, João F, Saretzki, Gabriele, Ahmed, Shaheda, Nelson, Glyn, Richter, Torsten, Peters, Heiko, Wappler, Ilka, Birket, Matthew J, Harold, Graham, Schaeuble, Karin, Birch-Machin, Mark A, Kirkwood, Thomas B L, von Zglinicki, Thomas
Published in PLoS biology (01.05.2007)
Published in PLoS biology (01.05.2007)
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CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Spyridopoulos, Ioakim, Martin‐Ruiz, Carmen, Hilkens, Catharien, Yadegarfar, Mohammad E., Isaacs, John, Jagger, Carol, Kirkwood, Tom, Zglinicki, Thomas
Published in Aging cell (01.04.2016)
Published in Aging cell (01.04.2016)
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Journal Article
Mitochondria are required for pro-ageing features of the senescent phenotype
Correia-Melo, Clara, Marques, Francisco DM, Anderson, Rhys, Hewitt, Graeme, Hewitt, Rachael, Cole, John, Carroll, Bernadette M, Miwa, Satomi, Birch, Jodie, Merz, Alina, Rushton, Michael D, Charles, Michelle, Jurk, Diana, Tait, Stephen WG, Czapiewski, Rafal, Greaves, Laura, Nelson, Glyn, Bohlooly-Y, Mohammad, Rodriguez-Cuenca, Sergio, Vidal-Puig, Antonio, Mann, Derek, Saretzki, Gabriele, Quarato, Giovanni, Green, Douglas R, Adams, Peter D, von Zglinicki, Thomas, Korolchuk, Viktor I, Passos, João F
Published in The EMBO journal (01.04.2016)
Published in The EMBO journal (01.04.2016)
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Journal Article
Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice
Fielder, Edward, Tweedy, Clare, Wilson, Caroline, Oakley, Fiona, LeBeau, Fiona E. N., Passos, João F., Mann, Derek A., Zglinicki, Thomas, Jurk, Diana
Published in Aging cell (01.10.2020)
Published in Aging cell (01.10.2020)
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Journal Article
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Fielder, Edward, von Zglinicki, Thomas, Jurk, Diana
Published in Journal of Alzheimer's disease (01.01.2017)
Published in Journal of Alzheimer's disease (01.01.2017)
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Journal Article
Surprisingly long survival of premature conclusions about naked mole‐rat biology
Braude, Stan, Holtze, Susanne, Begall, Sabine, Brenmoehl, Julia, Burda, Hynek, Dammann, Philip, Marmol, Delphine, Gorshkova, Ekaterina, Henning, Yoshiyuki, Hoeflich, Andreas, Höhn, Annika, Jung, Tobias, Hamo, Dania, Sahm, Arne, Shebzukhov, Yury, Šumbera, Radim, Miwa, Satomi, Vyssokikh, Mikhail Y., Zglinicki, Thomas, Averina, Olga, Hildebrandt, Thomas B.
Published in Biological reviews of the Cambridge Philosophical Society (01.04.2021)
Published in Biological reviews of the Cambridge Philosophical Society (01.04.2021)
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Journal Article
Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions
Dalle Pezze, Piero, Nelson, Glyn, Otten, Elsje G, Korolchuk, Viktor I, Kirkwood, Thomas B L, von Zglinicki, Thomas, Shanley, Daryl P
Published in PLoS computational biology (01.08.2014)
Published in PLoS computational biology (01.08.2014)
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Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice
Fielder, Edward, Wan, Tengfei, Alimohammadiha, Ghazaleh, Ishaq, Abbas, Low, Evon, Weigand, B Melanie, Kelly, George, Parker, Craig, Griffin, Brigid, Jurk, Diana, Korolchuk, Viktor I, von Zglinicki, Thomas, Miwa, Satomi
Published in eLife (04.05.2022)
Published in eLife (04.05.2022)
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Journal Article
Grip strength and inflammatory biomarker profiles in very old adults
Granic, Antoneta, Davies, Karen, Martin-Ruiz, Carmen, Jagger, Carol, Kirkwood, Thomas B L, von Zglinicki, Thomas, Aihie Sayer, Avan
Published in Age and ageing (01.11.2017)
Published in Age and ageing (01.11.2017)
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Journal Article
Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence
Novo, João P., Gee, Lucy, Caetano, Carolina A., Tomé, Inês, Vilaça, Andreia, Zglinicki, Thomas, Moreira, Irina S., Jurk, Diana, Rosa, Susana, Ferreira, Lino
Published in Aging cell (01.09.2024)
Published in Aging cell (01.09.2024)
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Journal Article
Senolytics and senostatics as adjuvant tumour therapy
Short, Susan, Fielder, Edward, Miwa, Satomi, von Zglinicki, Thomas
Published in EBioMedicine (01.03.2019)
Published in EBioMedicine (01.03.2019)
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Journal Article
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
Kelly, George, Kataura, Tetsushi, Panek, Johan, Ma, Gailing, Salmonowicz, Hanna, Davis, Ashley, Kendall, Hannah, Brookes, Charlotte, Ayine-Tora, Daniel Moscoh, Banks, Peter, Nelson, Glyn, Dobby, Laura, Pitrez, Patricia R., Booth, Laura, Costello, Lydia, Richardson, Gavin D., Lovat, Penny, Przyborski, Stefan, Ferreira, Lino, Greaves, Laura, Szczepanowska, Karolina, von Zglinicki, Thomas, Miwa, Satomi, Brown, Max, Flagler, Michael, Oblong, John E., Bascom, Charles C., Carroll, Bernadette, Reynisson, Jóhannes, Korolchuk, Viktor I.
Published in Developmental cell (05.08.2024)
Published in Developmental cell (05.08.2024)
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Journal Article
Telomere shortening reduces regenerative capacity after acute kidney injury
Westhoff, Jens H, Schildhorn, Carolin, Jacobi, Christoph, Hömme, Meike, Hartner, Andrea, Braun, Heidi, Kryzer, Christine, Wang, Chunfang, von Zglinicki, Thomas, Kränzlin, Bettina, Gretz, Norbert, Melk, Anette
Published in Journal of the American Society of Nephrology (01.02.2010)
Published in Journal of the American Society of Nephrology (01.02.2010)
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Journal Article
Replicative Aging, Telomeres, and Oxidative Stress
SARETZKI, GABRIELE, VON ZGLINICKI, THOMAS
Published in Annals of the New York Academy of Sciences (01.04.2002)
Published in Annals of the New York Academy of Sciences (01.04.2002)
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