Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
Afkhami, Sam, D’Agostino, Michael R., Zhang, Ali, Stacey, Hannah D., Marzok, Art, Kang, Alisha, Singh, Ramandeep, Bavananthasivam, Jegarubee, Ye, Gluke, Luo, Xiangqian, Wang, Fuan, Ang, Jann C., Zganiacz, Anna, Sankar, Uma, Kazhdan, Natallia, Koenig, Joshua F.E., Phelps, Allyssa, Gameiro, Steven F., Tang, Shangguo, Jordana, Manel, Wan, Yonghong, Mossman, Karen L., Jeyanathan, Mangalakumari, Gillgrass, Amy, Medina, Maria Fe C., Smaill, Fiona, Lichty, Brian D., Miller, Matthew S., Xing, Zhou
Published in Cell (03.03.2022)
Published in Cell (03.03.2022)
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CD11b + Dendritic Cell-Mediated Anti- Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103 + Dendritic Cells via IL-10
Lai, Rocky, Jeyanathan, Mangalakumari, Afkhami, Sam, Zganiacz, Anna, Hammill, Joanne A, Yao, Yushi, Kaushic, Charu, Xing, Zhou
Published in The Journal of immunology (1950) (01.03.2018)
Published in The Journal of immunology (1950) (01.03.2018)
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Intranasal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances Protection by Parenteral Mycobacterium bovis BCG Immunization against Pulmonary Tuberculosis
Santosuosso, Michael, McCormick, Sarah, Zhang, Xizhong, Zganiacz, Anna, Xing, Zhou
Published in Infection and Immunity (01.08.2006)
Published in Infection and Immunity (01.08.2006)
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Journal Article
Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung
Kang, Alisha, Ye, Gluke, Singh, Ramandeep, Afkhami, Sam, Bavananthasivam, Jegarubee, Luo, Xiangqian, Vaseghi‐Shanjani, Maryam, Aleithan, Fatemah, Zganiacz, Anna, Jeyanathan, Mangalakumari, Xing, Zhou
Published in EMBO molecular medicine (10.07.2023)
Published in EMBO molecular medicine (10.07.2023)
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Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes
Jeyanathan, Vidthiya, Afkhami, Sam, D'Agostino, Michael R, Zganiacz, Anna, Feng, Xueya, Miller, Matthew S, Jeyanathan, Mangalakumari, Thompson, Michael R, Xing, Zhou
Published in Frontiers in immunology (10.06.2022)
Published in Frontiers in immunology (10.06.2022)
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Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells
Haddadi, Siamak, Vaseghi-Shanjani, Maryam, Yao, Yushi, Afkhami, Sam, D'Agostino, Michael R, Zganiacz, Anna, Jeyanathan, Mangalakumari, Xing, Zhou
Published in Frontiers in immunology (06.09.2019)
Published in Frontiers in immunology (06.09.2019)
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Journal Article
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans
Jeyanathan, Mangalakumari, Fritz, Dominik K, Afkhami, Sam, Aguirre, Emilio, Howie, Karen J, Zganiacz, Anna, Dvorkin-Gheva, Anna, Thompson, Michael R, Silver, Richard F, Cusack, Ruth P, Lichty, Brian D, O'Byrne, Paul M, Kolb, Martin, Medina, Maria Fe C, Dolovich, Myrna B, Satia, Imran, Gauvreau, Gail M, Xing, Zhou, Smaill, Fiona
Published in JCI insight (08.02.2022)
Published in JCI insight (08.02.2022)
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Corrigendum: Differential biodistribution of adenoviral-vectored vaccine following intranasal and endotracheal deliveries leads to different immune outcomes
Jeyanathan, Vidthiya, Afkhami, Sam, D'Agostino, Michael R, Zganiacz, Anna, Feng, Xueya, Miller, Matthew S, Jeyanathan, Mangalakumari, Thompson, Michael R, Xing, Zhou
Published in Frontiers in immunology (07.02.2023)
Published in Frontiers in immunology (07.02.2023)
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Journal Article
Comparing Current and Next-Generation Humanized Mouse Models for Advancing HIV and HIV/Mtb Co-Infection Studies
Lepard, Madeleine, Yang, Jack X., Afkhami, Sam, Nazli, Aisha, Zganiacz, Anna, Tang, Shangguo, Choi, Margaret Wa Yan, Vahedi, Fatemah, Deshiere, Alexandre, Tremblay, Michel J., Xing, Zhou, Kaushic, Charu, Gillgrass, Amy
Published in Viruses (30.08.2022)
Published in Viruses (30.08.2022)
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Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis
Shaler, Christopher R, Horvath, Carly N, McCormick, Sarah, Jeyanathan, Mangalakumari, Khera, Amandeep, Zganiacz, Anna, Kasinska, Joanna, Stampfli, Martin R, Xing, Zhou
Published in PloS one (19.03.2013)
Published in PloS one (19.03.2013)
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Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice
Afkhami, Sam, D’Agostino, Michael R., Vaseghi-Shanjani, Maryam, Lepard, Madeleine, Yang, Jack X., Lai, Rocky, Choi, Margaret Wa Yan, Chacon, Alexis, Zganiacz, Anna, Franken, Kees L. M. C., Ertl, Hildegund C., Ottenhoff, Tom H. M., Jeyanathan, Mangalakumari, Gillgrass, Amy, Xing, Zhou
Published in npj vaccines (23.02.2023)
Published in npj vaccines (23.02.2023)
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Journal Article
Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model
Damjanovic, Daniela, Khera, Amandeep, Afkhami, Sam, Lai, Rocky, Zganiacz, Anna, Jeyanathan, Mangalakumari, Xing, Zhou
Published in PloS one (22.06.2015)
Published in PloS one (22.06.2015)
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Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during Pulmonary Mycobacterium bovis BCG Infection
Ngai, Patricia, McCormick, Sarah, Small, Cherrie, Zhang, Xizhong, Zganiacz, Anna, Aoki, Naoko, Xing, Zhou
Published in Infection and Immunity (01.05.2007)
Published in Infection and Immunity (01.05.2007)
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Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction
Xing, Zhou, Zganiacz, Anna, Santosuosso, Micheal
Published in Journal of leukocyte biology (01.12.2000)
Published in Journal of leukocyte biology (01.12.2000)
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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Jeyanathan, Mangalakumari, Vaseghi-Shanjani, Maryam, Afkhami, Sam, Grondin, Jensine A., Kang, Alisha, D’Agostino, Michael R., Yao, Yushi, Jain, Shreya, Zganiacz, Anna, Kroezen, Zachary, Shanmuganathan, Meera, Singh, Ramandeep, Dvorkin-Gheva, Anna, Britz-McKibbin, Philip, Khan, Waliul I., Xing, Zhou
Published in Nature immunology (01.12.2022)
Published in Nature immunology (01.12.2022)
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A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity
Smaill, Fiona, Jeyanathan, Mangalakumari, Smieja, Marek, Medina, Maria Fe, Thanthrige-Don, Niroshan, Zganiacz, Anna, Yin, Cindy, Heriazon, Armando, Damjanovic, Daniela, Puri, Laura, Hamid, Jemila, Xie, Feng, Foley, Ronan, Bramson, Jonathan, Gauldie, Jack, Xing, Zhou
Published in Science translational medicine (02.10.2013)
Published in Science translational medicine (02.10.2013)
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Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection
D'Agostino, Michael R, Lai, Rocky, Afkhami, Sam, Khera, Amandeep, Yao, Yushi, Vaseghi-Shanjani, Maryam, Zganiacz, Anna, Jeyanathan, Mangalakumari, Xing, Zhou
Published in The Journal of immunology (1950) (15.11.2020)
Published in The Journal of immunology (1950) (15.11.2020)
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Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation
Afkhami, Sam, Lai, Rocky, D’agostino, Michael R, Vaseghi-Shanjani, Maryam, Zganiacz, Anna, Yao, Yushi, Jeyanathan, Mangalakumari, Xing, Zhou
Published in The Journal of infectious diseases (13.09.2019)
Published in The Journal of infectious diseases (13.09.2019)
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