Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges
Zeng, Shenxin, Huang, Wenhai, Zheng, Xiaoliang, Liyan cheng, Zhang, Zhimin, Wang, Jian, Shen, Zhengrong
Published in European journal of medicinal chemistry (15.01.2021)
Published in European journal of medicinal chemistry (15.01.2021)
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Journal Article
The progress of molecules and strategies for the treatment of HBV infection
Pan, Youlu, Xia, Heye, He, Yanwen, Zeng, Shenxin, Shen, Zhengrong, Huang, Wenhai
Published in Frontiers in cellular and infection microbiology (15.03.2023)
Published in Frontiers in cellular and infection microbiology (15.03.2023)
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Journal Article
Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery
Zeng, Shenxin, Zhang, Hongjie, Shen, Zhengrong, Huang, Wenhai
Published in Frontiers in chemistry (10.03.2021)
Published in Frontiers in chemistry (10.03.2021)
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Journal Article
Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)
Zhang, Zhimin, Chang, Xinyue, Zhang, Chixiao, Zeng, Shenxin, Liang, Meihao, Ma, Zhen, Wang, Zunyuan, Huang, Wenhai, Shen, Zhengrong
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Journal Article
Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML
Li, Zilin, Xi, Yiling, Tu, Linglan, Zhang, Xu, Huang, Yue, Nie, Huizong, Peng, Cheng, Chai, Haohuan, Zeng, Shenxin, Zheng, Xiaoliang, Cheng, Liyan
Published in Biomedicine & pharmacotherapy (01.04.2024)
Published in Biomedicine & pharmacotherapy (01.04.2024)
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Journal Article
Discovery of orally available 1H-pyrazolo [3, 4-d] pyrimidin-4-amine derivative as a novel BTK inhibitor
ZunyuanWang, ShuWang, Chai, Jiazhe, Chi, Xinglong, Ying, Jiaxun, Kang, Youkun, Pan, Youlu, Zeng, Shenxin, Ma, Zhen, Wang, Wenyong, Huang, Wenhai
Published in Arabian journal of chemistry (01.09.2024)
Published in Arabian journal of chemistry (01.09.2024)
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Journal Article
Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping
Zhang, Zhimin, Gu, Lili, Wang, Beibei, Huang, Wenhai, Zhang, Yanmin, Ma, Zhen, Zeng, Shenxin, Shen, Zhengrong
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
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Journal Article
Current advances and development strategies of orally bioavailable PROTACs
Zeng, Shenxin, Ye, Yingqiao, Xia, Heye, Min, Jingli, Xu, Jiamei, Wang, Zunyuan, Pan, Youlu, Zhou, Xinglu, Huang, Wenhai
Published in European journal of medicinal chemistry (05.12.2023)
Published in European journal of medicinal chemistry (05.12.2023)
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Journal Article
Discovery of New Non-covalent Reversible BTK Inhibitors: Synthesis, in silico Studies, and in vitro Evaluations
Wang, Zunyuan, Wang, Shu, Kang, Youkun, Chi, Xinglong, Pan, Youlu, Zeng, Shenxin, Zhang, Chixiao, Xu, Xiangwei, Wang, Wenyong, Huang, Wenhai
Published in Chemico-biological interactions (13.09.2024)
Published in Chemico-biological interactions (13.09.2024)
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Journal Article
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton’s Tyrosine Kinase for the Treatment of Lymphoma
Zhang, Jingyu, Che, Jinxin, Luo, Xiaomin, Wu, Mingfei, Kan, Weijuan, Jin, Yuheng, Wang, Hanlin, Pang, Ao, Li, Cong, Huang, Wenhai, Zeng, Shenxin, Zhuang, Weihao, Wu, Yizhe, Xu, Yongjin, Zhou, Yubo, Li, Jia, Dong, Xiaowu
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Journal Article
Discovery of novel pyrrolo [2,3-d] pyrimidine derivatives as potent FAK inhibitors based on cyclization strategy
Zeng, Shenxin, Yuan, Shuai, Zhang, Yu, Du, Jinbei, Wu, Yuhao, Chen, Yinqiao, Zhu, Peizhen, Huang, Wenhai
Published in Bioorganic chemistry (01.10.2023)
Published in Bioorganic chemistry (01.10.2023)
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Journal Article
Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling
Zeng, Shenxin, Jin, Yuyuan, Xia, Heye, Shang, Yanwei, Li, Yingzhou, Wang, Zunyuan, Huang, Wenhai
Published in Bioorganic chemistry (01.02.2024)
Published in Bioorganic chemistry (01.02.2024)
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Journal Article
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody
Zeng, Shenxin, Wu, Mingfei, Jin, Yuyuan, Ye, Yingqiao, Xia, Heye, Chen, Xinyi, Che, Jinxin, Wang, Zunyuan, Wu, Ying, Dong, Xiaowu, Chen, Yinqiao, Huang, Wenhai
Published in European journal of medicinal chemistry (05.03.2024)
Published in European journal of medicinal chemistry (05.03.2024)
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Journal Article
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy
Wu, Mingfei, Wu, Yiquan, Jin, Yuyuan, Mao, Xinfei, Zeng, Shenxin, Yu, Hengyuan, Zhang, Jingyu, Jin, Yuheng, Wu, Yizhe, Xu, Tengfei, Chen, Yong, Wang, Yuwei, Yao, Xiaojun, Che, Jinxin, Huang, Wenhai, Dong, Xiaowu
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Cytarabine and EIP co-administration synergistically reduces viability of acute lymphoblastic leukemia cells with high ERG expression
Cheng, Liyan, Zeng, Shenxin, Yan, Dongmei, Tu, Linglan, Yang, Yadong, Wang, Xiaoju, Zheng, Xiaoliang
Published in Leukemia research (01.10.2021)
Published in Leukemia research (01.10.2021)
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Journal Article
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
Zhang, Jingyu, Duan, Haiting, Gui, Renzhao, Wu, Mingfei, Shen, Liteng, Jin, Yuheng, Pang, Ao, Yu, Xiaoli, Zeng, Shenxin, Zhang, Bo, Lin, Nengming, Huang, Wenhai, Wang, Yuwei, Yao, Xiaojun, Li, Jia, Dong, Xiaowu, Zhou, Yubo, Che, Jinxin
Published in European journal of medicinal chemistry (15.12.2023)
Published in European journal of medicinal chemistry (15.12.2023)
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Journal Article
Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML
Wu, Mingfei, Wang, Wei, Mao, Xinfei, Wu, Yiquan, Jin, Yuyuan, Liu, Tao, Lu, Yan, Dai, Haibin, Zeng, Shenxin, Huang, Wenhai, Wang, Yuwei, Yao, Xiaojun, Che, Jinxin, Ying, Meidan, Dong, Xiaowu
Published in European journal of medicinal chemistry (05.09.2024)
Published in European journal of medicinal chemistry (05.09.2024)
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Journal Article
The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance
Zhang, Xu, Tu, Linglan, Chai, Haohuan, Li, Zilin, Fu, Yuhan, Zheng, Xiaoliang, Zeng, Shenxin, Cheng, Liyan
Published in Journal of oncology (30.10.2022)
Published in Journal of oncology (30.10.2022)
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Journal Article
Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation
Zhi, Yanle, Wang, Shu, Huang, Wenhai, Zeng, Shenxin, Liang, Meihao, Zhang, Chixiao, Ma, Zhen, Wang, Zunyuan, Zhang, Zhimin, Shen, Zhengrong
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
Metal-free and One-pot for the Synthesis of Indolo[2,1-a]isoquinoline Aldehyde via a Free Radical Cascade Pathway followed by Direct Hydrolyzation
Pan, Youlu, Gong, Xiaomeng, Hao, Rongrong, Zeng, Shenxin, Xu, Jinghao, Shen, Zhengrong, Huang, Wenhai
Published in Asian journal of organic chemistry (01.02.2022)
Published in Asian journal of organic chemistry (01.02.2022)
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