The immunological and metabolic landscape in primary and metastatic liver cancer
Li, Xin, Ramadori, Pierluigi, Pfister, Dominik, Seehawer, Marco, Zender, Lars, Heikenwalder, Mathias
Published in Nature reviews. Cancer (01.09.2021)
Published in Nature reviews. Cancer (01.09.2021)
Get full text
Journal Article
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Glück, Selene, Guey, Baptiste, Gulen, Muhammet Fatih, Wolter, Katharina, Kang, Tae-Won, Schmacke, Niklas Arndt, Bridgeman, Anne, Rehwinkel, Jan, Zender, Lars, Ablasser, Andrea
Published in Nature cell biology (01.09.2017)
Published in Nature cell biology (01.09.2017)
Get full text
Journal Article
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M
Published in Genes & development (15.01.2017)
Published in Genes & development (15.01.2017)
Get full text
Journal Article
Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
Hinterleitner, Clemens, Strähle, Jasmin, Malenke, Elke, Hinterleitner, Martina, Henning, Melanie, Seehawer, Marco, Bilich, Tatjana, Heitmann, Jonas, Lutz, Martina, Mattern, Sven, Scheuermann, Sophia, Horger, Marius, Maurer, Stefanie, Walz, Juliane, Fend, Falko, Handgretinger, Rupert, Seitz, Christian, Weigelin, Bettina, Singer, Stephan, Salih, Helmut, Borst, Oliver, Kopp, Hans-Georg, Zender, Lars
Published in Nature communications (01.12.2021)
Published in Nature communications (01.12.2021)
Get full text
Journal Article
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
Eggert, Tobias, Wolter, Katharina, Ji, Juling, Ma, Chi, Yevsa, Tetyana, Klotz, Sabrina, Medina-Echeverz, José, Longerich, Thomas, Forgues, Marshonna, Reisinger, Florian, Heikenwalder, Mathias, Wang, Xin Wei, Zender, Lars, Greten, Tim F.
Published in Cancer cell (10.10.2016)
Published in Cancer cell (10.10.2016)
Get full text
Journal Article
Therapy-induced senescence — an induced synthetic lethality in liver cancer?
Wolter, Katharina, Zender, Lars
Published in Nature reviews. Gastroenterology & hepatology (01.03.2020)
Published in Nature reviews. Gastroenterology & hepatology (01.03.2020)
Get full text
Journal Article
NOTCH1 mediates a switch between two distinct secretomes during senescence
Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi
Published in Nature cell biology (01.09.2016)
Published in Nature cell biology (01.09.2016)
Get full text
Journal Article
Necroptosis microenvironment directs lineage commitment in liver cancer
Seehawer, Marco, Heinzmann, Florian, D’Artista, Luana, Harbig, Jule, Roux, Pierre-François, Hoenicke, Lisa, Dang, Hien, Klotz, Sabrina, Robinson, Lucas, Doré, Grégory, Rozenblum, Nir, Kang, Tae-Won, Chawla, Rishabh, Buch, Thorsten, Vucur, Mihael, Roth, Mareike, Zuber, Johannes, Luedde, Tom, Sipos, Bence, Longerich, Thomas, Heikenwälder, Mathias, Wang, Xin Wei, Bischof, Oliver, Zender, Lars
Published in Nature (London) (01.10.2018)
Published in Nature (London) (01.10.2018)
Get full text
Journal Article
CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
Reautschnig, Philipp, Wahn, Nicolai, Wettengel, Jacqueline, Schulz, Annika E., Latifi, Ngadhnjim, Vogel, Paul, Kang, Tae-Won, Pfeiffer, Laura S., Zarges, Christine, Naumann, Ulrike, Zender, Lars, Li, Jin Billy, Stafforst, Thorsten
Published in Nature biotechnology (01.05.2022)
Published in Nature biotechnology (01.05.2022)
Get full text
Journal Article
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J., Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., Gil, Jesús
Published in Nature cell biology (01.09.2015)
Published in Nature cell biology (01.09.2015)
Get full text
Journal Article
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús
Published in Cancer cell (09.07.2018)
Published in Cancer cell (09.07.2018)
Get full text
Journal Article
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús
Published in Nature cell biology (01.08.2013)
Published in Nature cell biology (01.08.2013)
Get full text
Journal Article
Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice
Moya, Iván M, Castaldo, Stéphanie A, Van den Mooter, Laura, Soheily, Soheil, Sansores-Garcia, Leticia, Jacobs, Jelle, Mannaerts, Inge, Xie, Jun, Verboven, Elisabeth, Hillen, Hanne, Algueró-Nadal, Ana, Karaman, Ruchan, Van Haele, Matthias, Kowalczyk, Weronika, De Waegeneer, Maxime, Verhulst, Stefaan, Karras, Panagiotis, van Huffel, Leen, Zender, Lars, Marine, Jean-Christophe, Roskams, Tania, Johnson, Randy, Aerts, Stein, van Grunsven, Leo A, Halder, Georg
Published in Science (American Association for the Advancement of Science) (22.11.2019)
Published in Science (American Association for the Advancement of Science) (22.11.2019)
Get full text
Journal Article
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, Valery, Yon, Monica, Dickins, Ross A., Hearn, Stephen, Simon, Janelle, Miething, Cornelius, Yee, Herman, Zender, Lars, Lowe, Scott W.
Published in Cell (22.08.2008)
Published in Cell (22.08.2008)
Get full text
Journal Article
Nucleoporin Nup155 is part of the p53 network in liver cancer
Holzer, Kerstin, Ori, Alessandro, Cooke, Amy, Dauch, Daniel, Drucker, Elisabeth, Riemenschneider, Philip, Andres-Pons, Amparo, DiGuilio, Amanda L., Mackmull, Marie-Therese, Baßler, Jochen, Roessler, Stephanie, Breuhahn, Kai, Zender, Lars, Glavy, Joseph S., Dombrowski, Frank, Hurt, Ed, Schirmacher, Peter, Beck, Martin, Singer, Stephan
Published in Nature communications (14.05.2019)
Published in Nature communications (14.05.2019)
Get full text
Journal Article
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models
Martinez-Quetglas, Iris, Pinyol, Roser, Dauch, Daniel, Torrecilla, Sara, Tovar, Victoria, Moeini, Agrin, Alsinet, Clara, Portela, Anna, Rodriguez-Carunchio, Leonardo, Solé, Manel, Lujambio, Amaia, Villanueva, Augusto, Thung, Swan, Esteller, Manel, Zender, Lars, Llovet, Josep M
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2016)
Get full text
Journal Article
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
Brenner, Ellen, Schörg, Barbara F., Ahmetlić, Fatima, Wieder, Thomas, Hilke, Franz Joachim, Simon, Nadine, Schroeder, Christopher, Demidov, German, Riedel, Tanja, Fehrenbacher, Birgit, Schaller, Martin, Forschner, Andrea, Eigentler, Thomas, Niessner, Heike, Sinnberg, Tobias, Böhm, Katharina S., Hömberg, Nadine, Braumüller, Heidi, Dauch, Daniel, Zwirner, Stefan, Zender, Lars, Sonanini, Dominik, Geishauser, Albert, Bauer, Jürgen, Eichner, Martin, Jarick, Katja J., Beilhack, Andreas, Biskup, Saskia, Döcker, Dennis, Schadendorf, Dirk, Quintanilla-Martinez, Leticia, Pichler, Bernd J., Kneilling, Manfred, Mocikat, Ralph, Röcken, Martin
Published in Nature communications (12.03.2020)
Published in Nature communications (12.03.2020)
Get full text
Journal Article
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma
Kapanadze, Tamar, Gamrekelashvili, Jaba, Ma, Chi, Chan, Carmen, Zhao, Fei, Hewitt, Stephen, Zender, Lars, Kapoor, Veena, Felsher, Dean W, Manns, Michael P, Korangy, Firouzeh, Greten, Tim F
Published in Journal of hepatology (01.11.2013)
Published in Journal of hepatology (01.11.2013)
Get full text
Journal Article