Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
Kuntimaddi, Aravinda, Achille, Nicholas J., Thorpe, Jeremy, Lokken, Alyson A., Singh, Ritambhara, Hemenway, Charles S., Adli, Mazhar, Zeleznik-Le, Nancy J., Bushweller, John H.
Published in Cell reports (Cambridge) (05.05.2015)
Published in Cell reports (Cambridge) (05.05.2015)
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FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells
You, Dewen, Xin, Junping, Volk, Andrew, Wei, Wei, Schmidt, Rachel, Scurti, Gina, Nand, Sucha, Breuer, Eun-Kyoung, Kuo, Paul C., Breslin, Peter, Kini, Ameet R., Nishimura, Michael I., Zeleznik-Le, Nancy J., Zhang, Jiwang
Published in Cell reports (Cambridge) (31.03.2015)
Published in Cell reports (Cambridge) (31.03.2015)
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FAK Is required for c‐Met/β‐catenin‐driven hepatocarcinogenesis
Shang, Na, Arteaga, Maribel, Zaidi, Ali, Stauffer, Jimmy, Cotler, Scott J., Zeleznik‐Le, Nancy J., Zhang, Jiwang, Qiu, Wei
Published in Hepatology (Baltimore, Md.) (01.01.2015)
Published in Hepatology (Baltimore, Md.) (01.01.2015)
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Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes
Chang, Ming-Jin, Wu, Hongyu, Achille, Nicholas J, Reisenauer, Mary Rose, Chou, Chau-Wen, Zeleznik-Le, Nancy J, Hemenway, Charles S, Zhang, Wenzheng
Published in Cancer research (Chicago, Ill.) (15.12.2010)
Published in Cancer research (Chicago, Ill.) (15.12.2010)
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Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia
Grembecka, Jolanta, Bushweller, John H, Risner, Laurie E, Lukasik, Stephen M, Cierpicki, Tomasz, Shultis, David D, Zeleznik-Le, Nancy J, Popovic, Relja, Omonkowska, Monika
Published in Nature structural & molecular biology (01.01.2010)
Published in Nature structural & molecular biology (01.01.2010)
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Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
Mi, Shuangli, Li, Zejuan, Chen, Ping, He, Chunjiang, Cao, Donglin, Elkahloun, Abdel, Lu, Jun, Pelloso, Luis A, Wunderlich, Mark, Huang, Hao, Luo, Roger T, Sun, Miao, He, Miao, Neilly, Mary Beth, Zeleznik-Le, Nancy J, Thirman, Michael J, Mulloy, James C, Liu, Paul P, Rowley, Janet D, Chen, Jianjun
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2010)
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Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional Activation
Mujtaba, Shiraz, He, Yan, Zeng, Lei, Yan, Sherry, Plotnikova, Olga, Sachchidanand, Sanchez, Roberto, Zeleznik-Le, Nancy J, Ronai, Ze'ev, Zhou, Ming-Ming
Published in Molecular cell (30.01.2004)
Published in Molecular cell (30.01.2004)
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Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia
Risner, Laurie E., Kuntimaddi, Aravinda, Lokken, Alyson A., Achille, Nicholas J., Birch, Noah W., Schoenfelt, Kelly, Bushweller, John H., Zeleznik-Le, Nancy J.
Published in The Journal of biological chemistry (11.10.2013)
Published in The Journal of biological chemistry (11.10.2013)
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Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Popovic, Relja, Riesbeck, Laurie E., Velu, Chinavenmeni S., Chaubey, Aditya, Zhang, Jiwang, Achille, Nicholas J., Erfurth, Frank E., Eaton, Katherine, Lu, Jun, Grimes, H. Leighton, Chen, Jianjun, Rowley, Janet D., Zeleznik-Le, Nancy J.
Published in Blood (02.04.2009)
Published in Blood (02.04.2009)
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MLL Protects CpG Clusters from Methylation within the Hoxa9 Gene, Maintaining Transcript Expression
Erfurth, Frank E., Popovic, Relja, Grembecka, Jolanta, Cierpicki, Tomasz, Theisler, Catherine, Xia, Zhen-Biao, Stuart, Tara, Diaz, Manuel O., Bushweller, John H., Zeleznik-Le, Nancy J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2008)
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MLL Repression Domain Interacts with Histone Deacetylases, the Polycomb Group Proteins HPC2 and BMI-1, and the Corepressor C-Terminal-Binding Protein
Xia, Zhen-Biao, Anderson, Melanie, Diaz, Manuel O., Zeleznik-Le, Nancy J.
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2003)
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Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients
Achille, Nicholas J, Othus, Megan, Phelan, Kathleen, Zhang, Shubin, Cooper, Kathrine, Godwin, John E, Appelbaum, Frederick R, Radich, Jerald P, Erba, Harry P, Nand, Sucha, Zeleznik-Le, Nancy J
Published in Leukemia research (01.03.2016)
Published in Leukemia research (01.03.2016)
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The MLL Fusion Gene, MLL-AF4, Regulates Cyclin-Dependent Kinase Inhibitor CDKN1B ( p27kip1) Expression
Xia, Zhen-Biao, Popovic, Relja, Chen, Jing, Theisler, Catherine, Stuart, Tara, Santillan, Donna A., Erfurth, Frank, Diaz, Manuel O., Zeleznik-Le, Nancy J., Rowley, Janet D.
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2005)
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miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
Li, Zejuan, Huang, Hao, Chen, Ping, He, Miao, Li, Yuanyuan, Arnovitz, Stephen, Jiang, Xi, He, Chunjiang, Hyjek, Elizabeth, Zhang, Jun, Zhang, Zhiyu, Elkahloun, Abdel, Cao, Donglin, Shen, Chen, Wunderlich, Mark, Wang, Yungui, Neilly, Mary Beth, Jin, Jie, Wei, Minjie, Lu, Jun, Valk, Peter J.M., Delwel, Ruud, Lowenberg, Bob, Le Beau, Michelle M., Vardiman, James, Mulloy, James C., Zeleznik-Le, Nancy J., Liu, Paul P., Zhang, Jiwang, Chen, Jianjun
Published in Nature communications (21.02.2012)
Published in Nature communications (21.02.2012)
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