Innate immune response to SARS‐CoV‐2 infection contributes to neuronal damage in human iPSC‐derived peripheral neurons
Passos, Vania, Henkel, Lisa M., Wang, Jiayi, Zapatero‐Belinchón, Francisco J., Möller, Rebecca, Sun, Guorong, Waltl, Inken, Schneider, Talia, Wachs, Amelie, Ritter, Birgit, Kropp, Kai A., Zhu, Shuyong, Deleidi, Michela, Kalinke, Ulrich, Schulz, Thomas F., Höglinger, Günter, Gerold, Gisa, Wegner, Florian, Viejo‐Borbolla, Abel
Published in Journal of medical virology (01.02.2024)
Published in Journal of medical virology (01.02.2024)
Get full text
Journal Article
Structure-Based Discovery of Inhibitors of the SARS-CoV‑2 Nsp14 N7-Methyltransferase
Singh, Isha, Li, Fengling, Fink, Elissa A., Chau, Irene, Li, Alice, Rodriguez-Hernández, Annía, Glenn, Isabella, Zapatero-Belinchón, Francisco J., Rodriguez, M. Luis, Devkota, Kanchan, Deng, Zhijie, White, Kris, Wan, Xiaobo, Tolmachova, Nataliya A., Moroz, Yurii S., Kaniskan, H. Ümit, Ott, Melanie, García-Sastre, Adolfo, Jin, Jian, Fujimori, Danica Galonić, Irwin, John J., Vedadi, Masoud, Shoichet, Brian K.
Published in Journal of medicinal chemistry (22.06.2023)
Published in Journal of medicinal chemistry (22.06.2023)
Get full text
Journal Article
The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity
Carriquí-Madroñal, Belén, Sheldon, Julie, Duven, Mara, Stegmann, Cora, Cirksena, Karsten, Wyler, Emanuel, Zapatero-Belinchón, Francisco J, Vondran, Florian W. R, Gerold, Gisa
Published in PLoS pathogens (01.11.2023)
Published in PLoS pathogens (01.11.2023)
Get full text
Journal Article
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Moeller, Rebecca, Hülskötter, Kirsten, Laurent, Timothée, Carlson, Lars-Anders, Goffinet, Christine, Simmons, Graham, Baumgärtner, Wolfgang, Gerold, Gisa
Published in mBio (28.06.2022)
Published in mBio (28.06.2022)
Get full text
Journal Article
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Mhlekude, Baxolele, Postmus, Dylan, Stenzel, Saskia, Weiner, 3rd, January, Jansen, Jenny, Zapatero-Belinchón, Francisco J, Olmer, Ruth, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Mühlemann, Barbara, Schroeder, Simon, Jones, Terry C, Müller, Marcel A, Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine
Published in PLoS pathogens (25.09.2023)
Published in PLoS pathogens (25.09.2023)
Get full text
Journal Article
Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells
Alvarez, Kris Gerard, Goral, Lisa, Suwandi, Abdulhadi, Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Ehrhardt, Katrin, Nagarathinam, Kumar, Künnemann, Katrin, Krey, Thomas, Wiedemann, Agnes, Gerold, Gisa, Grassl, Guntram A
Published in Virulence (01.12.2024)
Published in Virulence (01.12.2024)
Get full text
Journal Article
Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors
Zapatero-Belinchón, Francisco J, Dietzel, Erik, Dolnik, Olga, Döhner, Katinka, Costa, Rui, Hertel, Barbara, Veselkova, Barbora, Kirui, Jared, Klintworth, Anneke, Manns, Michael P, Pöhlmann, Stefan, Pietschmann, Thomas, Krey, Thomas, Ciesek, Sandra, Gerold, Gisa, Sodeik, Beate, Becker, Stephan, von Hahn, Thomas
Published in Viruses (19.03.2019)
Published in Viruses (19.03.2019)
Get full text
Journal Article
Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity
Zapatero-Belinchón, Francisco J., Ötjengerdes, Rina, Sheldon, Julie, Schulte, Benjamin, Carriquí-Madroñal, Belén, Brogden, Graham, Arroyo-Fernández, Laura M., Vondran, Florian W. R., Maasoumy, Benjamin, von Hahn, Thomas, Gerold, Gisa
Published in Cells (Basel, Switzerland) (29.06.2021)
Published in Cells (Basel, Switzerland) (29.06.2021)
Get full text
Journal Article
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease
Ricke-Hoch, Melanie, Stelling, Elisabeth, Lasswitz, Lisa, Gunesch, Antonia P, Kasten, Martina, Zapatero-Belinchón, Francisco J, Brogden, Graham, Gerold, Gisa, Pietschmann, Thomas, Montiel, Virginie, Balligand, Jean-Luc, Facciotti, Federica, Hirsch, Emilio, Gausepohl, Thomas, Elbahesh, Husni, Rimmelzwaan, Guus F, Höfer, Anne, Kühnel, Mark P, Jonigk, Danny, Eigendorf, Julian, Tegtbur, Uwe, Mink, Lena, Scherr, Michaela, Illig, Thomas, Schambach, Axel, Pfeffer, Tobias J, Hilfiker, Andres, Haverich, Axel, Hilfiker-Kleiner, Denise
Published in PloS one (04.08.2021)
Published in PloS one (04.08.2021)
Get full text
Journal Article
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Haid, Sibylle, Matthaei, Alina, Winkler, Melina, Sake, Svenja M, Gunesch, Antonia P, Milke, Vanessa, Köhler, Natalie M, Rückert, Jessica, Vieyres, Gabrielle, Kühl, David, Nguyen, Tu-Trinh, Göhl, Matthias, Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Brogden, Graham, Gerold, Gisa, Wiegmann, Bettina, Bilitewski, Ursula, Brown, Richard J P, Brönstrup, Mark, Schulz, Thomas F, Pietschmann, Thomas
Published in Antimicrobial agents and chemotherapy (06.03.2024)
Published in Antimicrobial agents and chemotherapy (06.03.2024)
Get full text
Journal Article
Understanding emerging and re-emerging viruses to facilitate pandemic preparedness
Zapatero-Belinchón, Francisco J., Kumar, Priti, Ott, Melanie, Schwartz, Olivier, Sigal, Alex
Published in Nature microbiology (01.09.2024)
Published in Nature microbiology (01.09.2024)
Get full text
Journal Article
Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis
Gunesch, Antonia P, Zapatero-Belinchón, Francisco J, Pinkert, Lukas, Steinmann, Eike, Manns, Michael P, Schneider, Gisbert, Pietschmann, Thomas, Brönstrup, Mark, von Hahn, Thomas
Published in Antimicrobial agents and chemotherapy (22.07.2020)
Published in Antimicrobial agents and chemotherapy (22.07.2020)
Get full text
Journal Article
Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
Zapatero-Belinchón, Francisco J., Moeller, Rebecca, Lasswitz, Lisa, van Ham, Marco, Becker, Miriam, Brogden, Graham, Rosendal, Ebba, Bi, Wenjie, Carriquí-Madroñal, Belén, Islam, Koushikul, Lenman, Annasara, Gunesch, Antonia P., Kirui, Jared, Pietschmann, Thomas, Överby, Anna K., Jänsch, Lothar, Gerold, Gisa
Published in iScience (17.12.2021)
Published in iScience (17.12.2021)
Get full text
Journal Article
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
Suryawanshi, Rahul K, Jaishankar, Priyadarshini, Correy, Galen J, Rachman, Moira M, O'Leary, Patrick C, Taha, Taha Y, Zapatero-Belinchón, Francisco J, McCavitt-Malvido, Maria, Doruk, Yagmur U, Stevens, Maisie G V, Diolaiti, Morgan E, Jogalekar, Manasi P, Richards, Alicia L, Montano, Mauricio, Rosecrans, Julia, Matthay, Michael, Togo, Takaya, Gonciarz, Ryan L, Gopalkrishnan, Saumya, Neitz, R Jeffrey, Krogan, Nevan J, Swaney, Danielle L, Shoichet, Brian K, Ott, Melanie, Renslo, Adam R, Ashworth, Alan, Fraser, James S
Published in bioRxiv (29.08.2024)
Published in bioRxiv (29.08.2024)
Get full text
Journal Article
The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity
Belén Carriquí-Madroñal, Julie Sheldon, Mara Duven, Cora Stegmann, Karsten Cirksena, Emanuel Wyler, Francisco J Zapatero-Belinchón, Florian W R Vondran, Gisa Gerold
Published in PLoS pathogens (01.11.2023)
Published in PLoS pathogens (01.11.2023)
Get full text
Journal Article
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease
Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P Gunesch, Martina Kasten, Francisco J Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F Rimmelzwaan, Anne Höfer, Mark P Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias J Pfeffer, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner
Published in PloS one (01.01.2021)
Published in PloS one (01.01.2021)
Get full text
Journal Article
Innate immune response to SARS-1 CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons
Passos, Vania, Henkel, Lisa M, Wang, Jiayi, Zapatero-Belinchon, Francisco J, Moeller, Rebecca, Sun, Guorong, Waltl, Inken, Ritter, Birgit, Kropp, Kai A, Zhu, Shuyong, Deleidi, Michela, Kalinke, Ulrich, Hoeglinger, Guenter, Gerold, Gisa, Wegner, Florian, Viejo-Borbolla, Abel
Published in bioRxiv (18.11.2022)
Published in bioRxiv (18.11.2022)
Get full text
Paper
Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase
Singh, Isha, Li, Fengling, Fink, Elissa, Chau, Irene, Li, Alice, Rodriguez-Hernandez, Annia, Glenn, Isabella, Zapatero-Belinchon, Francisco J, Rodriguez, Mario, Devkota, Kanchan, Deng, Zhijie, White, Kris, Wan, Xiaobo, Tolmachova, Nataliya A, Moroz, Yurii S, Kaniskan, H Umit, Ott, Melanie, Gastia-Sastre, Adolfo, Jin, Jian, Danica Galonic Fujimori, Irwin, John J, Vedadi, Masoud, Shoichet, Brian K
Published in bioRxiv (13.01.2023)
Published in bioRxiv (13.01.2023)
Get full text
Paper
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
Mhlekude, Baxolele, Postmus, Dylan, Weiner, January, Stenzel, Saskia, Zapatero-Belinchon, Francisco J, Olmer, Ruth, Jansen, Jenny, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Muhlemann, Barbara, Schroeder, Simon, Jones, Terry C, Muller, Marcel Alexander, Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine
Published in bioRxiv (23.09.2022)
Published in bioRxiv (23.09.2022)
Get full text
Paper