Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms
Tong, Ling, Yu, Wensheng, Chen, Lei, Selyutin, Oleg, Dwyer, Michael P, Nair, Anilkumar G, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Yin, Jingjun, Ruck, Rebecca T, Davies, Ian W, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Xia, Ellen, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Carr, Donna, Rokosz, Laura, Ingravallo, Paul, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants
Yu, Wensheng, Tong, Ling, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Coburn, Craig A, Selyutin, Oleg, Chen, Lei, Rokosz, Laura, Agrawal, Sony, Liu, Rong, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Journal Article
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions
Yu, Wensheng, Tong, Ling, Selyutin, Oleg, Chen, Lei, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Yin, Jingjun, Ruck, Rebecca T, Curry, Stephanie, McMonagle, Patricia, Agrawal, Sony, Rokosz, Laura, Carr, Donna, Ingravallo, Paul, Bystol, Karin, Lahser, Frederick, Liu, Rong, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742
Yu, Wensheng, Zhou, Guowei, Coburn, Craig A., Zeng, Qingbei, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Chen, Lei, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Selyutin, Oleg, Rosenblum, Stuart B., Lavey, Brian, Nair, Anilkumar G., Heon Kim, Seong, Keertikar, Kerry M., Rokosz, Laura, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors
Tong, Ling, Yu, Wensheng, Coburn, Craig A., Chen, Lei, Selyutin, Oleg, Zeng, Qingbei, Dwyer, Michael P., Nair, Anilkumar G., Shankar, Bandarpalle B., Kim, Seong Heon, Yang, De-Yi, Rosenblum, Stuart B., Ruck, Rebecca T., Davies, Ian W., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Carr, Donna, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Ingravallo, Paul, Chen, Shiying, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742
Yu, Wensheng, Coburn, Craig A., Nair, Anilkumar G., Wong, Michael, Rosenblum, Stuart B., Zhou, Guowei, Dwyer, Michael P., Tong, Ling, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Kim, Seong Heon, Zeng, Qingbei, Selyutin, Oleg, Chen, Lei, Masse, Frederic, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Lin, Mingxiang, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES
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Year of Publication 01.06.2017
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Year of Publication 01.06.2017
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HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES
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Year of Publication 20.04.2017
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Year of Publication 20.04.2017
Patent
HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES
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Year of Publication 15.09.2015
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Year of Publication 15.09.2015
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SERVO CONTROL METHOD AND SYSTEM FOR MULTI-JOINT HYDRAULIC MANIPULATOR BASED ON ADAPTIVE SLIDING MODE
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Foundation pit top prefabricated drainage ditch
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Rope-driven six-degree-of-freedom pose decoupling force feedback teleoperation master manipulator
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Year of Publication 26.03.2024
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Deep foundation pit bottom plate post-cast strip drainage and water supply circulation system construction method
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Year of Publication 24.03.2023
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Year of Publication 24.03.2023
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