Chemical optimization of Pneumocandin B0 and selection of the pre-clinical candidate Caspofungin
Balkovec, JM, Black, RM, Bouffard, FA, Dropinski, JF, Hammond, ML, Zambias, RA
Published in Planta Medica (01.07.2012)
Published in Planta Medica (01.07.2012)
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Conference Proceeding
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL CATIONIC PNEUMOCANDIN B-O DERIVATIVES
BOUFFARD, FA, ZAMBIAS, RA, DROPINSKI, JF, BALKOVEC, JM, HAMMOND, ML, ABRUZZO, GK, BARTIZAL, KF, MARRINAN, JA, KURTZ, MB, MCFADDEN, DC, NOLLSTADT, KH, POWLES, MA, SCHMATZ, DM
Published in Journal of medicinal chemistry (21.01.1994)
Published in Journal of medicinal chemistry (21.01.1994)
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Journal Article
Microchemical structural determination of a peptoid covalently bound to a polymeric bead by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Zambias, Robert A., Boulton, David A., Griffin, Patrick R.
Published in Tetrahedron letters (20.06.1994)
Published in Tetrahedron letters (20.06.1994)
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Journal Article
Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis
KURTZ, M. B, DOUGLAS, C, BOUFFARD, F. A, DROPINSKI, J. F, HAMMOND, M. L, ZAMBIAS, R. A, ABRUZZO, G, BARTIZAL, K, MCMANUS, O. B, GARCIA, M. L, MARRINAN, J, NOLLSTADT, K, ONISHI, J, DREIKORN, S, MILLIGAN, J, MANDALA, S, THOMPSON, J, BALKOVEC, J. M
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
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Journal Article
Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach
Zambias, Robert A, Hammond, Milton L, Heck, James V, Bartizal, Ken, Trainor, Charlotte, Abruzzo, George, Schmatz, Dennis M, Nollstadt, Karl M
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Journal Article
Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)
Balkovec, James M, Black, Regina M, Hammond, Milton L, Heck, James V, Zambias, Robert A, Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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Journal Article
Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560
Zambias, Robert A., James, Catherine, Abruzzo, George K., Bartizal, Kenneth F., Hajdu, Richard, Thompson, Randy, Nollstadt, Karl H., Marrinan, Jean, Balkovec, James M.
Published in Bioorganic & medicinal chemistry letters (05.08.1997)
Published in Bioorganic & medicinal chemistry letters (05.08.1997)
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Journal Article
Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B 0 derivatives
Zambias, Robert A., James, Catherine, Hammond, Milton L., Abruzzo, George K., Bartizal, Kenneth F., Nollstadt, Karl H., Douglas, Cameron, Marrinan, Jean, Balkovec, James M.
Published in Bioorganic & medicinal chemistry letters (19.10.1995)
Published in Bioorganic & medicinal chemistry letters (19.10.1995)
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Journal Article
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis
Hammond, Milton L, Kopka, Ihor E, Zambias, Robert A, Caldwell, Charles G, Boger, Joshua, Baker, Florence, Bach, Tom, Luell, Silvi, MacIntyre, D. Euan
Published in Journal of medicinal chemistry (01.05.1989)
Published in Journal of medicinal chemistry (01.05.1989)
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Journal Article
Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent
Hammond, Milton L, Zambias, Robert A, Chang, Michael N, Jensen, Norman P, McDonald, John, Thompson, Kathryn, Boulton, David A, Kopka, Ihor E, Hand, Karen M
Published in Journal of medicinal chemistry (01.03.1990)
Published in Journal of medicinal chemistry (01.03.1990)
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Journal Article
A convenient synthesis of 4-tert-butyl-5-benzofuranols and dihydrobenzofuranols
Zambias, Robert A, Caldwell, Charles G, Kopka, Ihor E, Hammond, Milton L
Published in Journal of organic chemistry (01.08.1988)
Published in Journal of organic chemistry (01.08.1988)
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Journal Article
The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic
Durette, Philippe L., Kopka, Ihor E., Lanza, Thomas J., Goulet, Joung L., Kinneary, Joanne F., Caldwell, Charles G., Hammond, Milton L., Bondy, Steven S., Zambias, Robert A., Boger, Joshua, Rollins, Thomas, Siciliano, Salvatore, Cianciarulo, Dana N., Kobayashi, Sumire V., Springer, Martin S., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (01.09.1992)
Published in Bioorganic & medicinal chemistry letters (01.09.1992)
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Journal Article