The PROTACtable genome
Schneider, Melanie, Radoux, Chris J., Hercules, Andrew, Ochoa, David, Dunham, Ian, Zalmas, Lykourgos-Panagiotis, Hessler, Gerhard, Ruf, Sven, Shanmugasundaram, Veerabahu, Hann, Michael M., Thomas, Pam J., Queisser, Markus A., Benowitz, Andrew B., Brown, Kris, Leach, Andrew R.
Published in Nature reviews. Drug discovery (01.10.2021)
Published in Nature reviews. Drug discovery (01.10.2021)
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Journal Article
Integrated systems biology approach identifies gene targets for endothelial dysfunction
Pinheiro‐de‐Sousa, Iguaracy, Fonseca‐Alaniz, Miriam Helena, Giudice, Girolamo, Valadão, Iuri Cordeiro, Modestia, Silvestre Massimo, Mattioli, Sarah Viana, Junior, Ricardo Rosa, Zalmas, Lykourgos‐Panagiotis, Fang, Yun, Petsalaki, Evangelia, Krieger, José Eduardo
Published in Molecular systems biology (06.12.2023)
Published in Molecular systems biology (06.12.2023)
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Journal Article
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation
Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.
Published in Cancer cell (09.11.2015)
Published in Cancer cell (09.11.2015)
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Journal Article
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
Kanu, Nnennaya, Cerone, Maria Antonietta, Goh, Gerald, Zalmas, Lykourgos-Panagiotis, Bartkova, Jirina, Dietzen, Michelle, McGranahan, Nicholas, Rogers, Rebecca, Law, Emily K, Gromova, Irina, Kschischo, Maik, Walton, Michael I, Rossanese, Olivia W, Bartek, Jiri, Harris, Reuben S, Venkatesan, Subramanian, Swanton, Charles
Published in Genome Biology (15.09.2016)
Published in Genome Biology (15.09.2016)
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Journal Article
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Pfister, Sophia X., Ahrabi, Sara, Zalmas, Lykourgos-Panagiotis, Sarkar, Sovan, Aymard, François, Bachrati, Csanád Z., Helleday, Thomas, Legube, Gaëlle, La Thangue, Nicholas B., Porter, Andrew C.G., Humphrey, Timothy C.
Published in Cell reports (Cambridge) (26.06.2014)
Published in Cell reports (Cambridge) (26.06.2014)
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Journal Article
Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1
Zheng, Shunsheng, Moehlenbrink, Jutta, Lu, Yi-Chien, Zalmas, Lykourgos-Panagiotis, Sagum, Cari A., Carr, Simon, McGouran, Joanna F., Alexander, Leila, Fedorov, Oleg, Munro, Shonagh, Kessler, Benedikt, Bedford, Mark T., Yu, Qiang, La Thangue, Nicholas B.
Published in Molecular cell (10.10.2013)
Published in Molecular cell (10.10.2013)
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Journal Article
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor
Carr, Simon M., Munro, Shonagh, Zalmas, Lykourgos-Panagiotis, Fedorov, Oleg, Johansson, Catrine, Krojer, Tobias, Sagum, Cari A., Bedford, Mark T., Oppermannb, Udo, La Thangue, Nicholas B.
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
Pacini, Clare, Duncan, Emma, Gonçalves, Emanuel, Gilbert, James, Bhosle, Shriram, Horswell, Stuart, Karakoc, Emre, Lightfoot, Howard, Curry, Ed, Muyas, Francesc, Bouaboula, Monsif, Pedamallu, Chandra Sekhar, Cortes-Ciriano, Isidro, Behan, Fiona M., Zalmas, Lykourgos-Panagiotis, Barthorpe, Andrew, Francies, Hayley, Rowley, Steve, Pollard, Jack, Beltrao, Pedro, Parts, Leopold, Iorio, Francesco, Garnett, Mathew J.
Published in Cancer cell (12.02.2024)
Published in Cancer cell (12.02.2024)
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Journal Article
A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest
Deiss, Katharina, Lockwood, Nicola, Howell, Michael, Segeren, Hendrika Alida, Saunders, Rebecca E, Chakravarty, Probir, Soliman, Tanya N, Martini, Silvia, Rocha, Nuno, Semple, Robert, Zalmas, Lykourgos-Panagiotis, Parker, Peter J
Published in Nucleic acids research (08.04.2019)
Published in Nucleic acids research (08.04.2019)
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Journal Article
E2F-7 couples DNA damage-dependent transcription with the DNA repair process
Zalmas, Lykourgos-Panagiotis, Coutts, Amanda, Helleday, Thomas, La Thangue, Nicholas B.
Published in Cell cycle (Georgetown, Tex.) (15.09.2013)
Published in Cell cycle (Georgetown, Tex.) (15.09.2013)
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Journal Article
Abstract 2567: TRACERx: Intra-tumor subclonal driver mutation results in defective DNA damage response (DDR) and genome instability
Lu, Wei-ting, Zalmas, Lykourgos-Panagiotis, Webber, Thomas, Kanu, Nnennaya, Swanton, Charles
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Venkatesan, Subramanian, Angelova, Mihaela, Puttick, Clare, Zhai, Haoran, Caswell, Deborah R, Lu, Wei-Ting, Dietzen, Michelle, Galanos, Panagiotis, Evangelou, Konstantinos, Bellelli, Roberto, Lim, Emilia L, Watkins, Thomas B K, Rowan, Andrew, Teixeira, Vitor H, Zhao, Yue, Chen, Haiquan, Ngo, Bryan, Zalmas, Lykourgos-Panagiotis, Al Bakir, Maise, Hobor, Sebastijan, Grönroos, Eva, Pennycuick, Adam, Nigro, Ersilia, Campbell, Brittany B, Brown, William L, Akarca, Ayse U, Marafioti, Teresa, Wu, Mary Y, Howell, Michael, Boulton, Simon J, Bertoli, Cosetta, Fenton, Tim R, de Bruin, Robertus A M, Maya-Mendoza, Apolinar, Santoni-Rugiu, Eric, Hynds, Robert E, Gorgoulis, Vassilis G, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Harris, Reuben S, Janes, Sam M, Bartkova, Jirina, Bakhoum, Samuel F, Bartek, Jiri, Kanu, Nnennaya, Swanton, Charles
Published in Cancer discovery (01.10.2021)
Published in Cancer discovery (01.10.2021)
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Journal Article
An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution
Zalmas, Lykourgos-Panagiotis, Lu, Wei-Ting, Kanu, Nnennaya
Published in Annals of translational medicine (01.07.2019)
Published in Annals of translational medicine (01.07.2019)
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Journal Article
Abstract LB237: Functional characterisation of TRACERx reveals mechanisms of NSCLC evolution
Lu, Wei-Ting, Zalmas, Lykourgos-Panagiotis, Bailey, Chris, Pich, Oriol, Ruiz, Carlos M., Black, James, Stavrou, Georgia, Biswas, Dhruva, Gimeno-Valiente, Francisco, Litchfield, Kevin, Bartek, Jiri, McGranahan, Nicholas, Kanu, Nnennaya, Swanton, Charles
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Abstract B40: WEE1 inhibition selectively kills histone H3K36me3-deficient cancers by dNTP starvation
Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Zalmas, Lykourgos-Panagiotis, Orlando, Giulia, Drobnitzky, Neele, Dianov, Grigory, Ying, Songmin, Thangue, Nicholas B. La, D'Angiolella, Vincenzo, Ryan, Anderson, Humphrey, Timothy C.
Published in Cancer research (Chicago, Ill.) (15.01.2016)
Published in Cancer research (Chicago, Ill.) (15.01.2016)
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Journal Article