The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo
Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F., Lavrik, O. I.
Published in Clinical & experimental metastasis (01.10.2021)
Published in Clinical & experimental metastasis (01.10.2021)
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Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models
Zakharenko, A.L., Luzina, O.A., Sokolov, D.N., Kaledin, V.I., Nikolin, V.P., Popova, N.A., Patel, J., Zakharova, O.D., Chepanova, A.A., Zafar, A., Reynisson, J., Leung, E., Leung, I.K.H., Volcho, K.P., Salakhutdinov, N.F., Lavrik, O.I.
Published in European journal of medicinal chemistry (01.01.2019)
Published in European journal of medicinal chemistry (01.01.2019)
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A two-phase solution procedure using mixtures of algorithms in the structure–property problem
Prokhorov, E. I., Svitan’ko, I. V., Zakharenko, A. L., Sukhanova, M. V., Bekker, A. V., Perevoznikov, A. V., Kumskov, M. I.
Published in Pattern recognition and image analysis (01.04.2016)
Published in Pattern recognition and image analysis (01.04.2016)
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Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening
Mamontova, E.M., Zakharenko, A.L., Zakharova, O.D., Dyrkheeva, N.S., Volcho, K.P., Reynisson, J., Arabshahi, H.J., Salakhutdinov, N.F., Lavrik, O.I.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
Chepanova, A. A., Zakharenko, A. L., Dyrkheeva, N. S., Chernyshova, I. A., Zakharova, O. D., Ilina, E. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.
Published in Doklady. Biochemistry and biophysics (01.02.2023)
Published in Doklady. Biochemistry and biophysics (01.02.2023)
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PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes
Zakharenko, A. L., Malakhova, A. A., Dyrkheeva, N. S., Okorokova, L. S., Medvedev, S. P., Zakian, S. M., Kabilov, M. R., Tupikin, A. A., Lavrik, O. I.
Published in Doklady. Biochemistry and biophysics (01.02.2023)
Published in Doklady. Biochemistry and biophysics (01.02.2023)
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2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors
Nilov, D. K., Yashina, K. I., Gushchina, I. V., Zakharenko, A. L., Sukhanova, M. V., Lavrik, O. I., Švedas, V. K.
Published in Biochemistry (Moscow) (01.02.2018)
Published in Biochemistry (Moscow) (01.02.2018)
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Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo
Kornienko, T E, Zakharenko, A L, Ilina, E S, Chepanova, A A, Zakharova, O D, Dyrkheeva, N S, Popova, N A, Nikolin, V P, Filimonov, A S, Luzina, O A, Salakhutdinov, N F, Lavrik, O I
Published in Molekuliarnaia biologiia (01.03.2023)
Published in Molekuliarnaia biologiia (01.03.2023)
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Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo
Kornienko, T. E., Zakharenko, A. L., Ilina, E. S., Chepanova, A. A., Zakharova, O. D., Dyrkheeva, N. S., Popova, N. A., Nikolin, V. P., Filimonov, A. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.
Published in Molecular biology (New York) (01.04.2023)
Published in Molecular biology (New York) (01.04.2023)
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Antimetastatic Activity of Combined Topotecan and Tyrosyl-DNA Phosphodiesterase-1 Inhibitor on Modeled Lewis Lung Carcinoma
Koldysheva, E. V., Men’shchikova, A. P., Lushnikova, E. L., Popova, N. A., Kaledin, V. I., Nikolin, V. P., Zakharenko, A. L., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.
Published in Bulletin of experimental biology and medicine (01.03.2019)
Published in Bulletin of experimental biology and medicine (01.03.2019)
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DNA Repair Enzymes as Promising Targets in Oncotherapy
Zakharenko, A. L., Lebedeva, N. A., Lavrik, O. I.
Published in Russian journal of bioorganic chemistry (2018)
Published in Russian journal of bioorganic chemistry (2018)
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Antitumor Activity of the Combination of Topotecan and Tyrosyl-DNA-Phosphodiesterase 1 Inhibitor on Model Krebs-2 Mouse Ascite Carcinoma
Dyrkheeva, N S, Zakharenko, A L, Novoselova, E S, Chepanova, A A, Popova, N A, Nikolin, V P, Luzina, O A, Salakhutdinov, N F, Ryabchikova, E I, Lavrik, O I
Published in Molekuliarnaia biologiia (01.03.2021)
Published in Molekuliarnaia biologiia (01.03.2021)
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Antitumor Activity of the Combination of Topotecan and Tyrosyl-DNA-Phosphodiesterase 1 Inhibitor on Model Krebs-2 Mouse Ascite Carcinoma
Dyrkheeva, N. S., Zakharenko, A. L., Novoselova, E. S., Chepanova, A. A., Popova, N. A., Nikolin, V. P., Luzina, O. A., Salakhutdinov, N. F., Ryabchikova, E. I., Lavrik, O. I.
Published in Molecular biology (New York) (01.03.2021)
Published in Molecular biology (New York) (01.03.2021)
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Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy
Chepanova, A. A., Li-Zhulanov, N. S., Sukhikh, A. S., Zafar, A., Reynisson, J., Zakharenko, A. L., Zakharova, O. D., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I.
Published in Russian journal of bioorganic chemistry (01.11.2019)
Published in Russian journal of bioorganic chemistry (01.11.2019)
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Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)
Zakharenko, A. L., Mozhaitsev, E. S., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I.
Published in Chemistry of natural compounds (01.07.2018)
Published in Chemistry of natural compounds (01.07.2018)
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Journal Article
Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1
Zakharenko, A. L., Luzina, O. A., Sokolov, D. N., Zakharova, O. D., Rakhmanova, M. E., Chepanova, A. A., Dyrkheeva, N. S., Lavrik, O. I., Salakhutdinov, N. F.
Published in Russian journal of bioorganic chemistry (2017)
Published in Russian journal of bioorganic chemistry (2017)
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Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
Gushchina, I V, Nilov, D K, Zakharenko, A L, Lavrik, O I, Švedas, V K
Published in Actanaturae (01.04.2017)
Published in Actanaturae (01.04.2017)
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Synthesis of a series of NAD+ analogues, potential inhibitors of PARP 1, using ADP conjugates functionalized at the terminal phosphate group
Sherstyuk, Yu. V., Zakharenko, A. L., Kutuzov, M. M., Sukhanova, M. V., Lavrik, O. I., Silnikov, V. N., Abramova, T. V.
Published in Russian journal of bioorganic chemistry (2017)
Published in Russian journal of bioorganic chemistry (2017)
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Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine
Nilov, D K, Tararov, V I, Kulikov, A V, Zakharenko, A L, Gushchina, I V, Mikhailov, S N, Lavrik, O I, Švedas, V K
Published in Actanaturae (01.04.2016)
Published in Actanaturae (01.04.2016)
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Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1
Zakharenko, A. L., Ponomarev, K. U., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Vasil’eva, I. A., Salakhutdinov, N. F., Lavrik, O. I.
Published in Russian journal of bioorganic chemistry (01.11.2015)
Published in Russian journal of bioorganic chemistry (01.11.2015)
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