Mechanisms underlying mutational signatures in human cancers
Helleday, Thomas, Eshtad, Saeed, Nik-Zainal, Serena
Published in Nature reviews. Genetics (01.09.2014)
Published in Nature reviews. Genetics (01.09.2014)
Get full text
Journal Article
Mutational signatures: emerging concepts, caveats and clinical applications
Koh, Gene, Degasperi, Andrea, Zou, Xueqing, Momen, Sophie, Nik-Zainal, Serena
Published in Nature reviews. Cancer (01.10.2021)
Published in Nature reviews. Cancer (01.10.2021)
Get full text
Journal Article
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer
Miller, R.E., Leary, A., Scott, C.L., Serra, V., Lord, C.J., Bowtell, D., Chang, D.K., Garsed, D.W., Jonkers, J., Ledermann, J.A., Nik-Zainal, S., Ray-Coquard, I., Shah, S.P., Matias-Guiu, X., Swisher, E.M., Yates, L.R.
Published in Annals of oncology (01.12.2020)
Published in Annals of oncology (01.12.2020)
Get full text
Journal Article
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer
Chopra, Neha, Tovey, Holly, Pearson, Alex, Cutts, Ros, Toms, Christy, Proszek, Paula, Hubank, Michael, Dowsett, Mitch, Dodson, Andrew, Daley, Frances, Kriplani, Divya, Gevensleben, Heidi, Davies, Helen Ruth, Degasperi, Andrea, Roylance, Rebecca, Chan, Stephen, Tutt, Andrew, Skene, Anthony, Evans, Abigail, Bliss, Judith M., Nik-Zainal, Serena, Turner, Nicholas C.
Published in Nature communications (29.05.2020)
Published in Nature communications (29.05.2020)
Get full text
Journal Article
A Compendium of Mutational Signatures of Environmental Agents
Kucab, Jill E., Zou, Xueqing, Morganella, Sandro, Joel, Madeleine, Nanda, A. Scott, Nagy, Eszter, Gomez, Celine, Degasperi, Andrea, Harris, Rebecca, Jackson, Stephen P., Arlt, Volker M., Phillips, David H., Nik-Zainal, Serena
Published in Cell (02.05.2019)
Published in Cell (02.05.2019)
Get full text
Journal Article
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Get full text
Journal Article
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
Thompson, Oliver, von Meyenn, Ferdinand, Hewitt, Zoe, Alexander, John, Wood, Andrew, Weightman, Richard, Gregory, Sian, Krueger, Felix, Andrews, Simon, Barbaric, Ivana, Gokhale, Paul J., Moore, Harry D., Reik, Wolf, Milo, Marta, Nik-Zainal, Serena, Yusa, Kosuke, Andrews, Peter W.
Published in Nature communications (23.03.2020)
Published in Nature communications (23.03.2020)
Get full text
Journal Article
Mutational signatures associated with tobacco smoking in human cancer
Alexandrov, Ludmil B., Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro, Nakagawa, Hidewaki, Shibata, Tatsuhiro, Campbell, Peter J., Vineis, Paolo, Phillips, David H., Stratton, Michael R.
Published in Science (American Association for the Advancement of Science) (04.11.2016)
Published in Science (American Association for the Advancement of Science) (04.11.2016)
Get full text
Journal Article
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
Iacobuzio-Donahue, Christine, Futreal, P. Andrew, Campbell, Peter J, Yachida, Shinichi, Mudie, Laura J, Stephens, Philip J, Pleasance, Erin D, Stebbings, Lucy A, Morsberger, Laura A, Latimer, Calli, McLaren, Stuart, Lin, Meng-Lay, McBride, David J, Varela, Ignacio, Nik-Zainal, Serena A, Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P, Teague, Jon W, Griffin, Constance A, Burton, John, Swerdlow, Harold, Quail, Michael A, Stratton, Michael R
Published in Nature (London) (28.10.2010)
Published in Nature (London) (28.10.2010)
Get full text
Journal Article
Validating the concept of mutational signatures with isogenic cell models
Zou, Xueqing, Owusu, Michel, Harris, Rebecca, Jackson, Stephen P., Loizou, Joanna I., Nik-Zainal, Serena
Published in Nature communications (01.05.2018)
Published in Nature communications (01.05.2018)
Get full text
Journal Article
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis
Taylor, Benjamin Jm, Nik-Zainal, Serena, Wu, Yee Ling, Stebbings, Lucy A, Raine, Keiran, Campbell, Peter J, Rada, Cristina, Stratton, Michael R, Neuberger, Michael S
Published in eLife (16.04.2013)
Published in eLife (16.04.2013)
Get full text
Journal Article
A mutational signature in gastric cancer suggests therapeutic strategies
Alexandrov, Ludmil B., Nik-Zainal, Serena, Siu, Hoi Cheong, Leung, Suet Yi, Stratton, Michael R
Published in Nature communications (29.10.2015)
Published in Nature communications (29.10.2015)
Get full text
Journal Article
Deciphering Signatures of Mutational Processes Operative in Human Cancer
Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Campbell, Peter J., Stratton, Michael R.
Published in Cell reports (Cambridge) (31.01.2013)
Published in Cell reports (Cambridge) (31.01.2013)
Get full text
Journal Article
Cellular survival over genomic perfection
Nik-Zainal, Serena, Hall, Benjamin A
Published in Science (American Association for the Advancement of Science) (15.11.2019)
Published in Science (American Association for the Advancement of Science) (15.11.2019)
Get full text
Journal Article
A practical guide for mutational signature analysis in hematological malignancies
Maura, Francesco, Degasperi, Andrea, Nadeu, Ferran, Leongamornlert, Daniel, Davies, Helen, Moore, Luiza, Royo, Romina, Ziccheddu, Bachisio, Puente, Xose S., Avet-Loiseau, Herve, Campbell, Peter J., Nik-Zainal, Serena, Campo, Elias, Munshi, Nikhil, Bolli, Niccolò
Published in Nature communications (05.07.2019)
Published in Nature communications (05.07.2019)
Get full text
Journal Article
Publication