Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia
Marcinkowska, Monika, Bucki, Adam, Sniecikowska, Joanna, Zagórska, Agnieszka, Fajkis-Zajączkowska, Nikola, Siwek, Agata, Gluch-Lutwin, Monika, Żmudzki, Paweł, Jastrzebska-Wiesek, Magdalena, Partyka, Anna, Wesołowska, Anna, Abram, Michał, Przejczowska-Pomierny, Katarzyna, Cios, Agnieszka, Wyska, Elżbieta, Mika, Kamil, Kotańska, Magdalena, Mierzejewski, Paweł, Kolaczkowski, Marcin
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model
Jaromin, Anna, Zarnowski, Robert, Markowski, Adam, Zagórska, Agnieszka, Johnson, Chad J, Etezadi, Haniyeh, Kihara, Shinji, Mota-Santiago, Pablo, Nett, Jeniel E, Boyd, Ben J, Andes, David R
Published in Antimicrobial agents and chemotherapy (10.01.2024)
Published in Antimicrobial agents and chemotherapy (10.01.2024)
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Exploring the antiplatelet activity of serotonin 5-HT2A receptor antagonists bearing 6-fluorobenzo[d]isoxazol-3-yl)propyl) motif– as potential therapeutic agents in the prevention of cardiovascular diseases
Marcinkowska, Monika, Kubacka, Monika, Zagorska, Agnieszka, Jaromin, Anna, Fajkis-Zajaczkowska, Nikola, Kolaczkowski, Marcin
Published in Biomedicine & pharmacotherapy (01.01.2022)
Published in Biomedicine & pharmacotherapy (01.01.2022)
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Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity
Dąbrowska, Monika, Starek, Małgorzata, Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Komsta, Łukasz, Jankowska, Agnieszka, Ślusarczyk, Marietta, Pawłowski, Maciej
Published in Bioorganic & medicinal chemistry letters (01.10.2021)
Published in Bioorganic & medicinal chemistry letters (01.10.2021)
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Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia
Zagórska, Agnieszka, Bucki, Adam, Partyka, Anna, Jastrzębska-Więsek, Magdalena, Siwek, Agata, Głuch-Lutwin, Monika, Mordyl, Barbara, Jaromin, Anna, Walczak, Maria, Wesołowska, Anna, Kołaczkowski, Marcin
Published in European journal of medicinal chemistry (05.04.2022)
Published in European journal of medicinal chemistry (05.04.2022)
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Reversed-phase thin-layer chromatography and ultra-performance liquid chromatography/mass spectrometry to estimate the drug likeness of phosphodiesterase 10A inhibitors with phthalimide core
Czopek, Anna, Żmudzki, Paweł, Dąbrowska, Monika, Starek, Małgorzata, Łątka, Kamil, Bajda, Marek, Jaromin, Anna, Fryc, Monika, Zagórska, Agnieszka
Published in JPC. Journal of planar chromatography, modern TLC (01.06.2024)
Published in JPC. Journal of planar chromatography, modern TLC (01.06.2024)
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Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core
Czopek, Anna, Byrtus, Hanna, Zagórska, Agnieszka, Rychtyk, Joanna, Góra, Małgorzata, Sałat, Kinga, Rapacz, Anna, Obniska, Jolanta
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold
Zagórska, Agnieszka, Partyka, Anna, Jastrzębska-Więsek, Magdalena, Czopek, Anna, Fryc, Monika, Siwek, Agata, Głuch-Lutwin, Monika, Mordyl, Barbara, Maślanka, Anna, Jaromin, Anna, Kurczab, Rafał
Published in Bioorganic chemistry (01.10.2023)
Published in Bioorganic chemistry (01.10.2023)
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Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability
Czopek, Anna, Bucki, Adam, Kołaczkowski, Marcin, Zagórska, Agnieszka, Drop, Marcin, Pawłowski, Maciej, Siwek, Agata, Głuch-Lutwin, Monika, Pękala, Elżbieta, Chrzanowska, Alicja, Struga, Marta, Partyka, Anna, Wesołowska, Anna
Published in Bioorganic & medicinal chemistry (15.09.2019)
Published in Bioorganic & medicinal chemistry (15.09.2019)
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Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin
Czopek, Anna, Byrtus, Hanna, Zagórska, Agnieszka, Siwek, Agata, Kazek, Grzegorz, Bednarski, Marek, Sapa, Jacek, Pawłowski, Maciej
Published in Pharmacological reports (01.10.2016)
Published in Pharmacological reports (01.10.2016)
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Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD)
Bucki, Adam, Marcinkowska, Monika, Śniecikowska, Joanna, Zagórska, Agnieszka, Jamrozik, Marek, Pawłowski, Maciej, Głuch-Lutwin, Monika, Siwek, Agata, Jakubczyk, Magdalena, Pytka, Karolina, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Wesołowska, Anna, Mierzejewski, Paweł, Kołaczkowski, Marcin
Published in European journal of medicinal chemistry (01.04.2020)
Published in European journal of medicinal chemistry (01.04.2020)
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Structure–activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity
Zagórska, Agnieszka, Kołaczkowski, Marcin, Bucki, Adam, Siwek, Agata, Kazek, Grzegorz, Satała, Grzegorz, Bojarski, Andrzej J., Partyka, Anna, Wesołowska, Anna, Pawłowski, Maciej
Published in European journal of medicinal chemistry (05.06.2015)
Published in European journal of medicinal chemistry (05.06.2015)
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Determination of ligand efficiency indices in a group of 7H‐purine‐2,6‐dione derivatives with psychotropic activity using micellar electrokinetic chromatography
Bajda, Marek, Chłoń‐Rzepa, Grażyna, Żmudzki, Paweł, Czopek, Anna, Stanisz‐Wallis, Krystyna, Łątka, Kamil, Pawłowski, Maciej, Zagórska, Agnieszka
Published in Electrophoresis (01.10.2018)
Published in Electrophoresis (01.10.2018)
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The use of biopharmaceuticals in the treatment of psoriasis
Partyka, Anna, Czopek, Anna, Stanisz-Wallis, Krystyna, Zagórska, Agnieszka
Published in Postȩpy higieny i medycyny doświadczalnej (18.07.2018)
Published in Postȩpy higieny i medycyny doświadczalnej (18.07.2018)
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Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents
Zagórska, Agnieszka, Bucki, Adam, Kołaczkowski, Marcin, Siwek, Agata, Głuch-Lutwin, Monika, Starowicz, Gabriela, Kazek, Grzegorz, Partyka, Anna, Wesołowska, Anna, Słoczyńska, Karolina, Pękala, Elżbieta, Pawłowski, Maciej
Published in Journal of enzyme inhibition and medicinal chemistry (03.11.2016)
Published in Journal of enzyme inhibition and medicinal chemistry (03.11.2016)
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Journal Article
Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities
Zagórska, Agnieszka, Partyka, Anna, Bucki, Adam, Kołaczkowski, Marcin, Jastrzębska‐Więsek, Magdalena, Czopek, Anna, Siwek, Agata, Głuch‐Lutwin, Monika, Bednarski, Marek, Bajda, Marek, Jończyk, Jakub, Piska, Kamil, Koczurkiewicz, Paulina, Wesołowska, Anna, Pawłowski, Maciej
Published in Chemical biology & drug design (01.04.2019)
Published in Chemical biology & drug design (01.04.2019)
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