Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23)
Errichiello, Edoardo, Zagnoli-Vieira, Guido, Rizzi, Romana, Garavelli, Livia, Caldecott, Keith W, Zuffardi, Orsetta
Published in Journal of human genetics (01.12.2020)
Published in Journal of human genetics (01.12.2020)
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Journal Article
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
Canela, Andres, Maman, Yaakov, Huang, Shar-yin N., Wutz, Gordana, Tang, Wen, Zagnoli-Vieira, Guido, Callen, Elsa, Wong, Nancy, Day, Amanda, Peters, Jan-Michael, Caldecott, Keith W., Pommier, Yves, Nussenzweig, André
Published in Molecular cell (25.07.2019)
Published in Molecular cell (25.07.2019)
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Journal Article
Combinatorial CRISPR screen identifies fitness effects of gene paralogues
Thompson, Nicola A., Ranzani, Marco, van der Weyden, Louise, Iyer, Vivek, Offord, Victoria, Droop, Alastair, Behan, Fiona, Gonçalves, Emanuel, Speak, Anneliese, Iorio, Francesco, Hewinson, James, Harle, Victoria, Robertson, Holly, Anderson, Elizabeth, Fu, Beiyuan, Yang, Fengtang, Zagnoli-Vieira, Guido, Chapman, Phil, Del Castillo Velasco-Herrera, Martin, Garnett, Mathew J., Jackson, Stephen P., Adams, David J.
Published in Nature communications (26.02.2021)
Published in Nature communications (26.02.2021)
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Journal Article
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Gómez-Herreros, Fernando, Zagnoli-Vieira, Guido, Ntai, Ioanna, Martínez-Macías, María Isabel, Anderson, Rhona M., Herrero-Ruíz, Andrés, Caldecott, Keith W.
Published in Nature communications (10.08.2017)
Published in Nature communications (10.08.2017)
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Journal Article
Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation
Holmes, Autumn C, Zagnoli-Vieira, Guido, Caldecott, Keith W, Semler, Bert L
Published in Viruses (31.01.2020)
Published in Viruses (31.01.2020)
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Journal Article
Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23)
Zagnoli-Vieira, Guido, Bruni, Francesco, Thompson, Kyle, He, Langping, Walker, Sarah, de Brouwer, Arjan P M, Taylor, Robert W, Niyazov, Dmitriy, Caldecott, Keith W
Published in Neurology. Genetics (01.08.2018)
Published in Neurology. Genetics (01.08.2018)
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Journal Article
Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia
Zagnoli-Vieira, Guido, Brazina, Jan, Van Den Bogaert, Kris, Huybrechts, Wim, Molenaers, Guy, Caldecott, Keith W., Van Esch, Hilde
Published in Human genetics (01.09.2023)
Published in Human genetics (01.09.2023)
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Journal Article
Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS
Carnie, Christopher J, Götz, Maximilian J, Palma-Chaundler, Chloe S, Weickert, Pedro, Wanders, Amy, Serrano-Benitez, Almudena, Li, Hao-Yi, Gupta, Vipul, Awwad, Samah W, Blum, Christian J, Sczaniecka-Clift, Matylda, Cordes, Jacqueline, Zagnoli-Vieira, Guido, D’Alessandro, Giuseppina, Richards, Sean L, Gueorguieva, Nadia, Lam, Simon, Beli, Petra, Stingele, Julian, Jackson, Stephen P
Published in The EMBO journal (17.06.2024)
Published in The EMBO journal (17.06.2024)
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Journal Article
RAD54L2 counters TOP2-DNA adducts to promote genome stability
D'Alessandro, Giuseppina, Morales-Juarez, David A, Richards, Sean L, Nitiss, Karin C, Serrano-Benitez, Almudena, Wang, Juanjuan, Thomas, John C, Gupta, Vipul, Voigt, Andrea, Belotserkovskaya, Rimma, Goh, Chen Gang, Bowden, Anne Ramsay, Galanty, Yaron, Beli, Petra, Nitiss, John L, Zagnoli-Vieira, Guido, Jackson, Stephen P
Published in Science advances (08.12.2023)
Published in Science advances (08.12.2023)
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Journal Article
Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity
Kaisinger, Lena R, Kentistou, Katherine A, Stankovic, Stasa, Gardner, Eugene J, Day, Felix R, Zhao, Yajie, Mörseburg, Alexander, Carnie, Christopher J, Zagnoli-Vieira, Guido, Puddu, Fabio, Jackson, Stephen P, O'Rahilly, Stephen, Farooqi, I Sadaf, Dearden, Laura, Pantaleão, Lucas C, Ozanne, Susan E, Ong, Ken K, Perry, John R B
Published in Cell genomics (09.08.2023)
Published in Cell genomics (09.08.2023)
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Journal Article
The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity
Carnie, Christopher J, Gotz, Maximilian J, Palma-Chaundler, Chloe S, Weickert, Pedro, Wanders, Amy R, Serrano-Benitez, Almudena, Hao-Yi, Li, Gupta, Vipul, Blum, Christian J, Sczaniecka-Clift, Matylda, Zagnoli-Vieira, Guido, D'alessandro, Giuseppina, Richards, Sean L, Gueorguieva, Nadia, Beli, Petra, Stingele, Julian, Jackson, Stephen P
Published in bioRxiv (21.12.2023)
Published in bioRxiv (21.12.2023)
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