Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Wagner, Allon, Wang, Chao, Fessler, Johannes, DeTomaso, David, Avila-Pacheco, Julian, Kaminski, James, Zaghouani, Sarah, Christian, Elena, Thakore, Pratiksha, Schellhaass, Brandon, Akama-Garren, Elliot, Pierce, Kerry, Singh, Vasundhara, Ron-Harel, Noga, Douglas, Vivian Paraskevi, Bod, Lloyd, Schnell, Alexandra, Puleston, Daniel, Sobel, Raymond A., Haigis, Marcia, Pearce, Erika L., Soleimani, Manoocher, Clish, Clary, Regev, Aviv, Kuchroo, Vijay K., Yosef, Nir
Published in Cell (05.08.2021)
Published in Cell (05.08.2021)
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Uncovering a role for B cells in antitumour immunity
Published in Nature (London)
(21.06.2023)
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B-cell-specific checkpoint molecules that regulate anti-tumour immunity
Bod, Lloyd, Kye, Yoon-Chul, Shi, Jingwen, Torlai Triglia, Elena, Schnell, Alexandra, Fessler, Johannes, Ostrowski, Stephen M., Von-Franque, Max Y., Kuchroo, Juhi R., Barilla, Rocky M., Zaghouani, Sarah, Christian, Elena, Delorey, Toni Marie, Mohib, Kanishka, Xiao, Sheng, Slingerland, Nadine, Giuliano, Christopher J., Ashenberg, Orr, Li, Zhaorong, Rothstein, David M., Fisher, David E., Rozenblatt-Rosen, Orit, Sharpe, Arlene H., Quintana, Francisco J., Apetoh, Lionel, Regev, Aviv, Kuchroo, Vijay K.
Published in Nature (London) (13.07.2023)
Published in Nature (London) (13.07.2023)
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An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
Zhu, Chen, Sakuishi, Kaori, Xiao, Sheng, Sun, Zhiyi, Zaghouani, Sarah, Gu, Guangxiang, Wang, Chao, Tan, Dewar J., Wu, Chuan, Rangachari, Manu, Pertel, Thomas, Jin, Hyun-Tak, Ahmed, Rafi, Anderson, Ana C., Kuchroo, Vijay K.
Published in Nature communications (23.01.2015)
Published in Nature communications (23.01.2015)
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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Thakore, Pratiksha I., Schnell, Alexandra, Huang, Linglin, Zhao, Maryann, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Singaraju, Anvita, Krishnan, Rajesh Kumar, Kozoriz, Deneen, Ma, Sai, Sankar, Venkat, Notarbartolo, Samuele, Buenrostro, Jason D., Sallusto, Federica, Patsopoulos, Nikolaos A., Rozenblatt-Rosen, Orit, Kuchroo, Vijay K., Regev, Aviv
Published in Nature immunology (01.08.2024)
Published in Nature immunology (01.08.2024)
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Journal Article
In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity
Wagner, Allon, Wang, Chao, DeTomaso, David, Pacheco, Julian Avila, Zaghouani, Sarah, Fessler, Johannes, Akama-Garren, Elliot, Pierce, Kerry, Ron-Harel, Noga, Haigis, Marcia, Sobel, Raymond A, Clish, Clary, Regev, Aviv, Kuchroo, Vijay K, Yosef, Nir
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion
Zhu, Chen, Dixon, Karen O, Newcomer, Kathleen, Gu, Guangxiang, Xiao, Sheng, Zaghouani, Sarah, Schramm, Markus A, Wang, Chao, Zhang, Huiyuan, Goto, Kouichiro, Christian, Elena, Rangachari, Manu, Rosenblatt-Rosen, Orit, Okada, Hitoshi, Mak, Tak, Singer, Meromit, Regev, Aviv, Kuchroo, Vijay
Published in Science advances (01.04.2021)
Published in Science advances (01.04.2021)
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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in T H 17 cells
Thakore, Pratiksha I, Schnell, Alexandra, Huang, Linglin, Zhao, Maryann, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Singaraju, Anvita, Krishnan, Rajesh Kumar, Kozoriz, Deneen, Ma, Sai, Sankar, Venkat, Notarbartolo, Samuele, Buenrostro, Jason D, Sallusto, Federica, Patsopoulos, Nikolaos A, Rozenblatt-Rosen, Orit, Kuchroo, Vijay K, Regev, Aviv
Published in Nature immunology (01.08.2024)
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Published in Nature immunology (01.08.2024)
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Recovery From Overt Type 1 Diabetes Ensues When Immune Tolerance and β-Cell Formation Are Coupled With Regeneration of Endothelial Cells in the Pancreatic Islets
XIAOXIAO WAN, GULOGLU, F. Betul, VANMORLAN, Amie M, ROWLAND, Linda M, ZAGHOUANI, Sarah, CASCIO, Jason A, DHAKAL, Mermagya, HOEMAN, Christine M, ZAGHOUANI, Habib
Published in Diabetes (New York, N.Y.) (01.08.2013)
Published in Diabetes (New York, N.Y.) (01.08.2013)
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Correction: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
Zhu, Chen, Sakuishi, Kaori, Xiao, Sheng, Sun, Zhiyi, Zaghouani, Sarah, Gu, Guangxiang, Wang, Chao, Tan, Dewar J., Wu, Chuan, Rangachari, Manu, Pertel, Thomas, Jin, Hyun-Tak, Ahmed, Rafi, Anderson, Ana C., Kuchroo, Vijay K.
Published in Nature communications (08.07.2015)
Published in Nature communications (08.07.2015)
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Recovery from overt type 1 diabetes ensues when immune tolerance and [beta]-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets
Wan, Xiaoxiao, Guloglu, F. Betul, VanMorlan, Amie M, Rowland, Linda M, Zaghouani, Sarah, Cascio, Jason A, Dhakal, Mermagya, Hoeman, Christine M, Zaghouani, Habib
Published in Diabetes (New York, N.Y.) (01.08.2013)
Published in Diabetes (New York, N.Y.) (01.08.2013)
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Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance
Cascio, Jason A, Haymaker, Cara L, Divekar, Rohit D, Zaghouani, Sarah, Khairallah, Marie-Therese, Wan, Xiaoxiao, Rowland, Linda M, Dhakal, Mermagya, Chen, Weirong, Zaghouani, Habib
Published in The Journal of immunology (1950) (15.06.2013)
Published in The Journal of immunology (1950) (15.06.2013)
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Journal Article
Bone Marrow-Derived IL-13R alpha 1-Positive Thymic Progenitors Are Restricted to the Myeloid Lineage
Haymaker, Cara L, Guloglu, FBetul, Cascio, Jason A, Hardaway, John C, Dhakal, Mermagya, Wan, Xiaoxiao, Hoeman, Christine M, Zaghouani, Sarah, Rowland, Linda M, Tartar, Danielle M, VanMorlan, Amie M, Zaghouani, Habib
Published in The Journal of immunology (1950) (01.04.2012)
Published in The Journal of immunology (1950) (01.04.2012)
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Journal Article
Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage
Haymaker, Cara L, Guloglu, F Betul, Cascio, Jason A, Hardaway, John C, Dhakal, Mermagya, Wan, Xiaoxiao, Hoeman, Christine M, Zaghouani, Sarah, Rowland, Linda M, Tartar, Danielle M, VanMorlan, Amie M, Zaghouani, Habib
Published in The Journal of immunology (1950) (01.04.2012)
Published in The Journal of immunology (1950) (01.04.2012)
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Journal Article
Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
Zhu, Chen, Sakuishi, Kaori, Xiao, Sheng, Sun, Zhiyi, Zaghouani, Sarah, Gu, Guangxiang, Wang, Chao, Tan, Dewar J, Wu, Chuan, Rangachari, Manu, Pertel, Thomas, Jin, Hyun-Tak, Ahmed, Rafi, Anderson, Ana C, Kuchroo, Vijay K
Published in Nature communications (08.07.2015)
Published in Nature communications (08.07.2015)
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Journal Article
The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity
Wang, Chao, Wagner, Allon, Fessler, Johannes, DeTomaso, David, Zaghouani, Sarah, Zhou, Yulin, Pierce, Kerry, Sobel, Raymond A, Clish, Clary, Yosef, Nir, Kuchroo, Vijay K
Published in bioRxiv (19.08.2024)
Published in bioRxiv (19.08.2024)
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Journal Article
The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states
Thakore, Pratiksha I, Schnell, Alexandra, Zhao, Maryann, Huang, Linglin, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Ma, Sai, Sankar, Venkat, Notarbartolo, Samuele, Buenrostro, Jason D, Sallusto, Federica, Patsopoulos, Nikolaos A, Rozenblatt-Rosen, Orit, Kuchroo, Vijay K, Regev, Aviv
Published in bioRxiv (26.02.2022)
Published in bioRxiv (26.02.2022)
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Paper
In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity
Wagner, Allon, Wang, Chao, Detomaso, David, Avila-Pacheco, Julian, Zaghouani, Sarah, Fessler, Johannes, Eyzaguirre, Sequoia, Akama-Garren, Elliot, Pierce, Kerry, Ron-Harel, Noga, Vivian, Paraskevi Douglas, Haigis, Marcia, Sobel, Raymond A, Clary Clish, Regev, Aviv, Kuchroo, Vijay K, Nir Yosef
Published in bioRxiv (24.03.2020)
Published in bioRxiv (24.03.2020)
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Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway
Wang, Chao, Wagner, Allon, Fessler, Johannes, Avila-Pacheco, Julian, Karminski, Jim, Thakore, Pratiksha, Zaghouani, Sarah, Pierce, Kerry, Bod, Lloyd, Schnell, Alexandra, Detomaso, David, Ron-Harel, Noga, Haigis, Marcia, Puleston, Daniel, Pearce, Erika, Soleimani, Manoocher, Sobel, Ray, Clary Clish, Regev, Aviv, Nir Yosef, Kuchroo, Vijay
Published in bioRxiv (23.01.2020)
Published in bioRxiv (23.01.2020)
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