Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum
Newby, Zachary E R, Robles-Colmenares, Yaneth, Khademi, Shahram, O'Connell III, Joseph, Stroud, Robert M, Miercke, Larry J
Published in Nature structural & molecular biology (01.06.2008)
Published in Nature structural & molecular biology (01.06.2008)
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Journal Article
A general protocol for the crystallization of membrane proteins for X-ray structural investigation
Stroud, Robert M, Newby, Zachary E R, O'Connell, Joseph D, Gruswitz, Franz, Hays, Franklin A, Harries, William E C, Harwood, Ian M, Ho, Joseph D, Lee, John K, Savage, David F, Miercke, Larry J W
Published in Nature protocols (01.01.2009)
Published in Nature protocols (01.01.2009)
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Journal Article
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.
Published in Bioorganic & medicinal chemistry (01.02.2019)
Published in Bioorganic & medicinal chemistry (01.02.2019)
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Journal Article
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Farand, Julie, Mai, Nicholas, Chandrasekhar, Jayaraman, Newby, Zachary E., Van Veldhuizen, Josh, Loyer-Drew, Jennifer, Venkataramani, Chandrasekar, Guerrero, Juan, Kwok, Amy, Li, Ning, Zherebina, Yelena, Wilbert, Sibylle, Zablocki, Jeff, Phillips, Gary, Watkins, William J., Mourey, Robert, Notte, Gregory T.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Journal Article
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation
Farand, Julie, Kropf, Jeffrey E, Blomgren, Peter, Xu, Jianjun, Schmitt, Aaron C, Newby, Zachary E, Wang, Ting, Murakami, Eisuke, Barauskas, Ona, Sudhamsu, Jawahar, Feng, Joy Y, Niedziela-Majka, Anita, Schultz, Brian E, Schwartz, Karen, Viatchenko-Karpinski, Serge, Kornyeyev, Dmytro, Kashishian, Adam, Fan, Peidong, Chen, Xiaowu, Lansdon, Eric B, Ports, Michael O, Currie, Kevin S, Watkins, William J, Notte, Gregory T
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Journal Article
Cell‐free complements in vivo expression of the E. coli membrane proteome
Savage, David F., Anderson, Corey L., Robles‐Colmenares, Yaneth, Newby, Zachary E., Stroud, Robert M.
Published in Protein science (01.05.2007)
Published in Protein science (01.05.2007)
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Journal Article
The Role of Protein Dynamics in Thymidylate Synthase Catalysis: Variants of Conserved 2‘-Deoxyuridine 5‘-Monophosphate (dUMP)-Binding Tyr-261
Newby, Zachary, Lee, Tom T, Morse, Richard J, Liu, Yaoquan, Liu, Lu, Venkatraman, Prasanna, Santi, Daniel V, Finer-Moore, Janet S, Stroud, Robert M
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Journal Article
A Theoretical Examination of the Factors Controlling the Catalytic Efficiency of the DNA-(Adenine-N6)-Methyltransferase from Thermus aquaticus
Zachary E. R. Newby, Lau, Edmond Y., Bruice, Thomas C.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2002)
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Journal Article
A Theoretical Examination of the Acid-Catalyzed and Noncatalyzed Ring-Opening Reaction of an Oxirane by Nucleophilic Addition of Acetate. Implications to Epoxide Hydrolases
Lau, Edmond Y, Newby, Zachary E, Bruice, Thomas C
Published in Journal of the American Chemical Society (11.04.2001)
Published in Journal of the American Chemical Society (11.04.2001)
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Journal Article
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety
Pero, Joseph E., Mueller, Elizabeth A., Adams, Ashley M., Adolph, Ramona S., Bagchi, Parikshit, Balce, Dale, Bantscheff, Marcus, Barauskas, Ona, Bartha, Istvan, Bohan, Dana, Cai, Haiying, Carabajal, Esteban, Cassidy, James, Cato, Matthew, Chaudhary, Khuram W., Chen, Dingjun, Chen, Yi-Pei, Colas, Christophe, Darwech, Isra, Eberl, H. Christian, Fernandez, Beth, Gordon, Earl, Grosse, Johannes, Hansen, Justin, Hetzler, Belinda, Hwang, Seungmin, Jeyasingh, Sam, Kowalski, Beatriz, Lehmann, Stephanie, Lo, Gary, McAllaster, Michael, McHugh, Charles, Momont, Corey, Newby, Zachary, Nigro, Maria, Oladunni, Fatai, Pannirselvam, Malar, Park, Arnold, Pearson, Neil, Peat, Andrew J., Plastridge, Bob, Ranjan, Rohit, Safabakhsh, Pegah, Shapiro, Nathan D., Soriaga, Leah, Stokes, Neil, Sweeney, David, Talecki, Lindsey, Telenti, Amalio, Terrell, Ashley, Tse, Winston, Wang, Lisha, Wang, Shuya, Wedel, Laura, Werner, Thilo, Dalmas Wilk, Deidre, Yim, Samantha, Zhou, Jiayi
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
MCL-1 INHIBITORS
WATKINS WILLIAM J, HWANG TAE H, DEVAN NADUTHAMBI, DAVID W LIN, SCOTT E LAZERWITH, JUAN A GUERRERO, CHU HANG, KOBAYASHI TETSUYA, ANNA E HURTLEY, LI XIAOFEN, DARRYL KATO, YANG HONG, CHANDRASEKAR VENKATARAMANI, JONATHAN W MEDLEY, JIANG LAN, MICHAEL L MITCHELL, ZACHARY NEWBY, NEIL H SQUIRES, JOHN E KNOX, VICKIE H TSUI
Year of Publication 01.07.2021
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Year of Publication 01.07.2021
Patent
HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE
PERO, Joseph E, CAI, Haiying, CASSIDY, James, NEWBY, Zachary, HETZLER, Belinda, SHAPIRO, Nathan, RANJAN, Rohit
Year of Publication 23.10.2024
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Year of Publication 23.10.2024
Patent
The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261
Newby, Zachary, Lee, Tom T., Morse, Richard J., Liu, Lu, Liu, Yaoquan, Venkatraman, Prasanna, Santi, Daniel V., Finer-Moore, Janet S., Stroud, Robert M.
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Journal Article
HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE
PERO, Joseph E, CAI, Haiying, CASSIDY, James, NEWBY, Zachary, HETZLER, Belinda, SHAPIRO, Nathan, RANJAN, Rohit
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent
Heterocyclic Carboxylate Compounds as Glycolate Oxidase Inhibitors
Lee, Amy S, Newby, Zachary ER, Xu, Lianhong, Shivakumar, Devleena M, Pyun, Hyung-Jung, Desai, Manoj C, Knox, John E, Guo, Hongyan
Year of Publication 21.03.2024
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Year of Publication 21.03.2024
Patent
Heterocyclic carboxylate compounds as glycolate oxidase inhibitors
Lee, Amy S, Xu, Lianhong, Shivakumar, Devleena M, Pyun, Hyung-Jung, Desai, Manoj C, Newby, Zachary E R, Knox, John E, Guo, Hongyan
Year of Publication 07.11.2023
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Year of Publication 07.11.2023
Patent
HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
LIANHONG XU, NEWBY, Zachary ER, MANOJ C DESAI, AURPON W MITRA, HONGYAN GUO, AMY S LEE, JOHN E KNOX, JULIAN A CODELLI, DEVLEENA M SHIVAKUMAR, HYUNG-JUNG PYUN
Year of Publication 28.08.2024
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Year of Publication 28.08.2024
Patent