Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair
MORGAN, Meredith A, PARSELS, Leslie A, CANMAN, Christine E, NORMOLLE, Daniel P, ZABLUDOFF, Sonya D, MAYBAUM, Jonathan, LAWRENCE, Theodore S, LILI ZHAO, PARSELS, Joshua D, DAVIS, Mary A, HASSAN, Maria C, ARUMUGARAJAH, Sankari, HYLANDER-GANS, Linda, MOROSINI, Deborah, SIMEONE, Diane M
Published in Cancer research (Chicago, Ill.) (15.06.2010)
Published in Cancer research (Chicago, Ill.) (15.06.2010)
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Journal Article
In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762
MITCHELL, James B, CHOUDHURI, Rajani, FABRE, Kristin, SOWERS, Anastasia L, CITRIN, Deborah, ZABLUDOFF, Sonya D, COOK, John A
Published in Clinical cancer research (01.04.2010)
Published in Clinical cancer research (01.04.2010)
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Journal Article
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Journal Article
Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition
Venkatesha, Venkatasubbaiah A, Parsels, Leslie A, Parsels, Joshua D, Zhao, Lili, Zabludoff, Sonya D, Simeone, Diane M, Maybaum, Jonathan, Lawrence, Theodore S, Morgan, Meredith A
Published in Neoplasia (New York, N.Y.) (01.06.2012)
Published in Neoplasia (New York, N.Y.) (01.06.2012)
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Journal Article
Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
PARSELS, Leslie A, YUSHEN QIAN, MOROSINI, Deborah, BROWN, Jeffrey L, ZABLUDOFF, Sonya D, MAYBAUM, Jonathan, LAWRENCE, Theodore S, MORGAN, Meredith A, TANSKA, Daria M, GROSS, Marisa, LILI ZHAO, HASSAN, Maria C, ARUMUGARAJAH, Sankari, PARSELS, Joshua D, HYLANDER-GANS, Linda, SIMEONE, Diane M
Published in Clinical cancer research (01.06.2011)
Published in Clinical cancer research (01.06.2011)
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Journal Article
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
Kung, Andrew L, Zabludoff, Sonya D, France, Dennis S, Freedman, Steven J, Tanner, Elizabeth A, Vieira, Annelisa, Cornell-Kennon, Susan, Lee, Jennifer, Wang, Beqing, Wang, Jamin, Memmert, Klaus, Naegeli, Hans-Ulrich, Petersen, Frank, Eck, Michael J, Bair, Kenneth W, Wood, Alexander W, Livingston, David M
Published in Cancer cell (01.07.2004)
Published in Cancer cell (01.07.2004)
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Journal Article
Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry
Parsels, Leslie A, Tanska, Daria M, Parsels, Joshua D, Zabludoff, Sonya D, Cuneo, Kyle C, Lawrence, Theodore S, Maybaum, Jonathan, Morgan, Meredith A
Published in Cell cycle (Georgetown, Tex.) (03.03.2016)
Published in Cell cycle (Georgetown, Tex.) (03.03.2016)
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Journal Article
Abstract 3919: Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition
Venkatesha, Venkatasubbaiah A., Parsels, Leslie A., Parsels, Joshua D., Zabludoff, Sonya D., Maybaum, Jonathan, Lawrence, Theodore S., Morgan, Meredith A.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition1
Venkatesha, Venkatasubbaiah A, Parsels, Leslie A, Parsels, Joshua D, Zhao, Lili, Zabludoff, Sonya D, Simeone, Diane M, Maybaum, Jonathan, Lawrence, Theodore S, Morgan, Meredith A
Published in Neoplasia (New York, N.Y.) (01.06.2012)
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Published in Neoplasia (New York, N.Y.) (01.06.2012)
Journal Article
Abstract 2964: AZD7762-mediated gemcitabine sensitization does not require G2-M checkpoint abrogation in pancreatic cancer cells
Parsels, Leslie A., Tanska, Daria M., Parsels, Joshua D., Zabludoff, Sonya D., Brown, Jeffrey L., Morgan, Meredith A., Lawrence, Theodore S., Maybaum, Jonathan
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Abstract 1765: Preclinical optimization of the Chk1/2 inhibitor AZD7762 in combination with gemcitabine in pancreatic cancer
Parsels, Leslie A., Morgan, Meredith A., Tanska, Daria M., Parsels, Joshua D., Davis, Mary A., Hassan, Maria C., Arumugarajah, Sankari, Hylander-Gans, Linda, Morosini, Deborah, Zhao, Lili, Simeone, Diane M., Canman, Christine E., Normolle, Daniel P., Zabludoff, Sonya D., Lawrence, Theodore S., Maybaum, Jonathan
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry
Parsels, Leslie A., Tanska, Daria M., Parsels, Joshua D., Zabludoff, Sonya D., Cuneo, Kyle C., Lawrence, Theodore S., Maybaum, Jonathan, Morgan, Meredith A.
Published in Cell Cycle (03.03.2016)
Published in Cell Cycle (03.03.2016)
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