Search Results - "ZONZINI, Laura" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1 Receptor Antagonist

Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1 Receptor Antagonist

by Di Fabio, Romano, Griffante, Cristiana, Alvaro, Giuseppe, Pentassuglia, Giorgio, Pizzi, Domenica A, Donati, Daniele, Rossi, Tino, Guercio, Giuseppe, Mattioli, Mario, Cimarosti, Zadeo, Marchioro, Carla, Provera, Stefano, Zonzini, Laura, Montanari, Dino, Melotto, Sergio, Gerrard, Philip A, Trist, David G, Ratti, Emiliangelo, Corsi, Mauro
Published in Journal of medicinal chemistry (28.05.2009)

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Synthesis and structure–activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

Synthesis and structure–activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

by Biagetti, Matteo, Leslie, Colin Philip, Mazzali, Angelica, Seri, Catia, Pizzi, Domenica Antonia, Bentley, Jonathan, Genski, Thorsten, Fabio, Romano Di, Zonzini, Laura, Caberlotto, Laura
Published in Bioorganic & medicinal chemistry letters (15.08.2010)

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Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

by Micheli, Fabrizio, Cremonesi, Susanna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Cavanni, Paolo, Oliosi, Beatrice, Perdonà, Elisabetta, Sava, Anna, Zonzini, Laura, Feriani, Aldo, Braggio, Simone, Heidbreder, Christian
Published in Bioorganic & medicinal chemistry letters (15.02.2016)

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1,2,4-Triazolyl 5‑Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists

1,2,4-Triazolyl 5‑Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists

by Micheli, Fabrizio, Bacchi, Alessia, Braggio, Simone, Castelletti, Laura, Cavallini, Palmina, Cavanni, Paolo, Cremonesi, Susanna, Dal Cin, Michele, Feriani, Aldo, Gehanne, Sylvie, Kajbaf, Mahmud, Marchió, Luciano, Nola, Selena, Oliosi, Beatrice, Pellacani, Annalisa, Perdonà, Elisabetta, Sava, Anna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Wong, Andrea, Visentini, Filippo, Zonzini, Laura, Heidbreder, Christian
Published in Journal of medicinal chemistry (22.09.2016)

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1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists

1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists

by Micheli, Fabrizio, Bernardelli, Andrea, Bianchi, Federica, Braggio, Simone, Castelletti, Laura, Cavallini, Palmina, Cavanni, Paolo, Cremonesi, Susanna, Cin, Michele Dal, Feriani, Aldo, Oliosi, Beatrice, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Wong, Andrea, Visentini, Filippo, Zonzini, Laura, Heidbreder, Christian
Published in Bioorganic & medicinal chemistry (15.04.2016)

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The NK 1 receptor antagonist aprepitant attenuates NK 1 agonist‐induced scratching behaviour in the gerbil after intra‐dermal, topical or oral administration

The NK 1 receptor antagonist aprepitant attenuates NK 1 agonist‐induced scratching behaviour in the gerbil after intra‐dermal, topical or oral administration

by Costantini, Vivian J. A., Corsi, Mauro, Dünstl, Georg, Bettelini, Letizia, Zonzini, Laura, Gerrard, Philip
Published in Experimental dermatology (01.04.2015)

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The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration

The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration

by Costantini, Vivian J. A., Corsi, Mauro, Dünstl, Georg, Bettelini, Letizia, Zonzini, Laura, Gerrard, Philip
Published in Experimental dermatology (01.04.2015)

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1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Triple Reuptake Inhibitors

1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Triple Reuptake Inhibitors

by Micheli, Fabrizio, Cavanni, Paolo, Arban, Roberto, Benedetti, Roberto, Bertani, Barbara, Bettati, Michela, Bettelini, Letizia, Bonanomi, Giorgio, Braggio, Simone, Checchia, Anna, Davalli, Silvia, Di Fabio, Romano, Fazzolari, Elettra, Fontana, Stefano, Marchioro, Carla, Minick, Doug, Negri, Michele, Oliosi, Beatrice, Read, Kevin D, Sartori, Ilaria, Tedesco, Giovanna, Tarsi, Luca, Terreni, Silvia, Visentini, Filippo, Zocchi, Alessandro, Zonzini, Laura
Published in Journal of medicinal chemistry (25.03.2010)

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Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045)

Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045)

by Bromidge, Steven M, Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano, Gianotti, Massimo, Gordon, Laurie J, Granci, Enrica, Leslie, Colin P, Moccia, Luca, Pasquarello, Alessandra, Sartori, Ilaria, Sava, Anna, Watson, Jeannette M, Worby, Angela, Zonzini, Laura, Zucchelli, Valeria
Published in Journal of medicinal chemistry (12.08.2010)

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In vitro and in vivo characterization of the novel GABA B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE)

In vitro and in vivo characterization of the novel GABA B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE)

by Perdona’, Elisabetta, Costantini, Vivian J.A., Tessari, Michela, Martinelli, Prisca, Carignani, Corrado, Valerio, Enzo, Mok, M.H. Selina, Zonzini, Laura, Visentini, Filippo, Gianotti, Massimo, Gordon, Laurie, Rocheville, Magalie, Corsi, Mauro, Capelli, Anna Maria
Published in Neuropharmacology (01.10.2011)

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Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT 1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4 H -imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide (GSK588045)

Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT 1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4 H -imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide (GSK588045)

by Bromidge, Steven M., Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano, Gianotti, Massimo, Gordon, Laurie J., Granci, Enrica, Leslie, Colin P., Moccia, Luca, Pasquarello, Alessandra, Sartori, Ilaria, Sava, Anna, Watson, Jeannette M., Worby, Angela, Zonzini, Laura, Zucchelli, Valeria
Published in Journal of medicinal chemistry (12.08.2010)

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Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

by Di Fabio, Romano, Alvaro, Giuseppe, Griffante, Cristiana, Pizzi, Domenica A, Donati, Daniele, Mattioli, Mario, Cimarosti, Zadeo, Guercio, Giuseppe, Marchioro, Carla, Provera, Stefano, Zonzini, Laura, Montanari, Dino, Melotto, Sergio, Gerrard, Philip A, Trist, David G, Ratti, Emiliangelo, Corsi, Mauro
Published in Journal of medicinal chemistry (24.02.2011)

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In vivo rat PK profiling in drug discovery: new challenges

In vivo rat PK profiling in drug discovery: new challenges

by Zonzini, Laura, Bianchi, Federica, Cesari, Nicola, Sartori, Matteo
Published in Expert opinion on drug discovery (01.11.2010)

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Journal Article

1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: Further insights into a class of triple re-uptake inhibitors

1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: Further insights into a class of triple re-uptake inhibitors

by Micheli, Fabrizio, Cavanni, Paolo, Bettati, Michela, Bonanomi, Giorgio, Di Fabio, Romano, Fazzolari, Elettra, Marchioro, Carla, Roscic, Maja, Tarsi, Luca, Visentini, Filippo, Zonzini, Laura, Worby, Angela
Published in Bioorganic & medicinal chemistry (01.06.2011)

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Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: A new class of Neuropeptide S antagonists

Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: A new class of Neuropeptide S antagonists

by MICHELI, Fabrizio, DI FABIO, Romano, ZARANTONELLO, Paola, ZONZINI, Laura, CAPELLI, Anna Maria, GIACOMETTI, Angelo, ROTH, Adelheid, MORO, Elisa, MERLO, Giancarlo, PAIO, Alfredo, MERLO-PICH, Emilio, TOMELLERI, Silvia, TONELLI, Federica
Published in Bioorganic & medicinal chemistry letters (15.12.2010)

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Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists

Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists

by Pizzi, Domenica Antonia, Leslie, Colin Philip, Mazzali, Angelica, Seri, Catia, Biagetti, Matteo, Bentley, Jonathan, Genski, Thorsten, Di Fabio, Romano, Contini, Stefania, Sabbatini, Fabio Maria, Zonzini, Laura, Caberlotto, Laura
Published in Bioorganic & medicinal chemistry letters (01.12.2010)

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Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT 1A/B/D Receptor Antagonist

Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT 1A/B/D Receptor Antagonist

by Leslie, Colin P., Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M., Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J., Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A., Stasi, Luigi P., Tibasco, Jessica, Vong, Antonio, Ward, Simon E., Zonzini, Laura
Published in Journal of medicinal chemistry (09.12.2010)

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Journal Article

Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT1A/B/D Receptor Antagonist

Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT1A/B/D Receptor Antagonist

by Leslie, Colin P, Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M, Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J, Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A, Stasi, Luigi P, Tibasco, Jessica, Vong, Antonio, Ward, Simon E, Zonzini, Laura
Published in Journal of medicinal chemistry (09.12.2010)

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8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II

8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II

by Bromidge, Steven M, Bertani, Barbara, Borriello, Manuela, Bozzoli, Andrea, Faedo, Stefania, Gianotti, Massimo, Gordon, Laurie J, Hill, Matthew, Zucchelli, Valeria, Watson, Jeannette M, Zonzini, Laura
Published in Bioorganic & medicinal chemistry letters (15.04.2009)

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In vitro and in vivo characterization of the novel GABA sub(B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2- p iperidinyl}ethanol (CMPPE))

In vitro and in vivo characterization of the novel GABA sub(B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2- p iperidinyl}ethanol (CMPPE))

by Perdona', Elisabetta, Costantini, Vivian JA, Tessari, Michela, Martinelli, Prisca, Carignani, Corrado, Valerio, Enzo, Mok, MHSelina, Zonzini, Laura, Visentini, Filippo, Gianotti, Massimo, Gordon, Laurie, Rocheville, Magalie, Corsi, Mauro, Capelli, Anna Maria
Published in Neuropharmacology (01.11.2011)

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