Kinetics study of the natural split Npu DnaE intein in the generation of bispecific IgG antibodies
Zong, Huifang, Han, Lei, Chen, Jie, Pan, Zhidi, Wang, Lei, Sun, Rui, Ding, Kai, Xie, Yueqing, Jiang, Hua, Lu, Huili, Gilly, John, Zhang, Baohong, Zhu, Jianwei
Published in Applied microbiology and biotechnology (2022)
Published in Applied microbiology and biotechnology (2022)
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Journal Article
Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system
Han, Lei, Chen, Junsheng, Ding, Kai, Zong, Huifang, Xie, Yueqing, Jiang, Hua, Zhang, Baohong, Lu, Huili, Yin, Weihan, Gilly, John, Zhu, Jianwei
Published in Scientific reports (21.08.2017)
Published in Scientific reports (21.08.2017)
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Journal Article
A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer
Zhou, Yuexian, Zong, Huifang, Han, Lei, Xie, Yueqing, Jiang, Hua, Gilly, John, Zhang, Baohong, Lu, Huili, Chen, Jie, Sun, Rui, Pan, Zhidi, Zhu, Jianwei
Published in Journal of experimental & clinical cancer research (12.05.2020)
Published in Journal of experimental & clinical cancer research (12.05.2020)
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Journal Article
Re-Engineering Therapeutic Anti-Aβ Monoclonal Antibody to Target Amyloid Light Chain
Bai, Jingyi, Li, Xi, Zhao, Jun, Zong, Huifang, Yuan, Yuan, Wang, Lei, Zhang, Xiaoshuai, Ke, Yong, Han, Lei, Xu, Jianrong, Ma, Buyong, Zhang, Baohong, Zhu, Jianwei
Published in International journal of molecular sciences (01.02.2024)
Published in International journal of molecular sciences (01.02.2024)
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Journal Article
Naturally split intein Npu DnaE mediated rapid generation of bispecific IgG antibodies
Han, Lei, Zong, Huifang, Zhou, Yuexian, Pan, Zhidi, Chen, Jie, Ding, Kai, Xie, Yueqing, Jiang, Hua, Zhang, Baohong, Lu, Huili, Gilly, John, Zhu, Jianwei
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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Journal Article
A Rational Designed Novel Bispecific Antibody for the Treatment of GBM
Sun, Rui, Zhou, Yuexian, Han, Lei, Pan, Zhidi, Chen, Jie, Zong, Huifang, Bian, Yanlin, Jiang, Hua, Zhang, Baohong, Zhu, Jianwei
Published in Biomedicines (03.06.2021)
Published in Biomedicines (03.06.2021)
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Journal Article
IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer
Wang, Lei, Qiao, Yu, Zong, Huifang, Han, Lei, Ke, Yong, Pan, ZhiDi, Chen, Jie, Lu, Jun, Li, Jinyao, Ying, Tianlei, Zhang, Baohong, Zhu, Jianwei
Published in Frontiers in pharmacology (23.02.2022)
Published in Frontiers in pharmacology (23.02.2022)
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Journal Article
Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement
Pan, Zhidi, Chen, Jie, Xiao, Xiaodong, Xie, Yueqing, Jiang, Hua, Zhang, Baohong, Lu, Huili, Yuan, Yunsheng, Han, Lei, Zhou, Yuexian, Zong, Huifang, Wang, Lei, Sun, Rui, Zhu, Jianwei
Published in Acta pharmaceutica Sinica. B (01.04.2022)
Published in Acta pharmaceutica Sinica. B (01.04.2022)
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Journal Article
A Novel Bispecific Antibody Targeting CD3 and Lewis Y with Potent Therapeutic Efficacy against Gastric Cancer
Chen, Jie, Pan, Zhidi, Han, Lei, Zhou, Yuexian, Zong, Huifang, Wang, Lei, Sun, Rui, Jiang, Hua, Xie, Yueqing, Yuan, Yunsheng, Wu, Mingyuan, Bian, Yanling, Zhang, Baohong, Zhu, Jianwei
Published in Biomedicines (20.08.2021)
Published in Biomedicines (20.08.2021)
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Journal Article
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD
Ma, Hang, Guo, Yingying, Tang, Haoneng, Tseng, Chien-Te K., Wang, Lei, Zong, Huifang, Wang, Zhenyu, He, Yang, Chang, Yunsong, Wang, Shusheng, Huang, Haiqiu, Ke, Yong, Yuan, Yunsheng, Wu, Mingyuan, Zhang, Yuanyuan, Drelich, Aleksandra, Kempaiah, Kempaiah Rayavara, Peng, Bi-Hung, Wang, Ailin, Yang, Kaiyong, Yin, Haiyang, Liu, Junjun, Yue, Yali, Xu, Wenbo, Zhu, Shuangli, Ji, Tianjiao, Zhang, Xiaoju, Wang, Ziqi, Li, Gang, Liu, Guangchun, Song, Jingjing, Mu, Lingling, Xiang, ZongShang, Song, Zhangyi, Chen, Hua, Bian, Yanlin, Zhang, Baohong, Chen, Hui, Zhang, Jiawei, Liao, Yunji, Zhang, Li, Yang, Li, Chen, Yi, Gilly, John, Xiao, Xiaodong, Han, Lei, Jiang, Hua, Xie, Yueqing, Zhou, Qiang, Zhu, Jianwei
Published in Cell discovery (15.02.2022)
Published in Cell discovery (15.02.2022)
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Production process reproducibility and product quality consistency of transient gene expression in HEK293 cells with anti-PD1 antibody as the model protein
Ding, Kai, Han, Lei, Zong, Huifang, Chen, Junsheng, Zhang, Baohong, Zhu, Jianwei
Published in Applied microbiology and biotechnology (01.03.2017)
Published in Applied microbiology and biotechnology (01.03.2017)
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Journal Article
Supramolecular antibody-drug conjugates for combined antibody therapy and photothermal therapy targeting HER2-positive cancers
Min, Yijia, Chen, Yu, Wang, Lei, Ke, Yong, Rong, Fan, He, Qunye, Paerhati, Pameila, Zong, Huifang, Zhu, Jianwei, Wang, Yin, Zhang, Baohong
Published in International journal of biological macromolecules (01.10.2024)
Published in International journal of biological macromolecules (01.10.2024)
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Journal Article
Bioprocess development of a stable FUT8−/−-CHO cell line to produce defucosylated anti-HER2 antibody
Yuan, Yuan, Zong, Huifang, Bai, Jingyi, Han, Lei, Wang, Lei, Zhang, Xinyu, Zhang, Xiaoshuai, Zhang, Jingyi, Xu, Chenxiao, Zhu, Jianwei, Zhang, Baohong
Published in Bioprocess and biosystems engineering (01.08.2019)
Published in Bioprocess and biosystems engineering (01.08.2019)
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Journal Article
Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-xL and Mcl-1
Zhang, Xinyu, Han, Lei, Zong, Huifang, Ding, Kai, Yuan, Yuan, Bai, Jingyi, Zhou, Yuexian, Zhang, Baohong, Zhu, Jianwei
Published in Bioprocess and biosystems engineering (2018)
Published in Bioprocess and biosystems engineering (2018)
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Journal Article
Producing defucosylated antibodies with enhanced in vitro antibody‐dependent cellular cytotoxicity via FUT8 knockout CHO‐S cells
Zong, Huifang, Han, Lei, Ding, Kai, Wang, Jiaxian, Sun, Tao, Zhang, Xinyu, Cagliero, Cedric, Jiang, Hua, Xie, Yueqing, Xu, Jianrong, Zhang, Baohong, Zhu, Jianwei
Published in Engineering in life sciences (01.07.2017)
Published in Engineering in life sciences (01.07.2017)
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Journal Article
Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-x L and Mcl-1
Zhang, Xinyu, Han, Lei, Zong, Huifang, Ding, Kai, Yuan, Yuan, Bai, Jingyi, Zhou, Yuexian, Zhang, Baohong, Zhu, Jianwei
Published in Bioprocess and biosystems engineering (01.05.2018)
Published in Bioprocess and biosystems engineering (01.05.2018)
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Journal Article
Enhanced Production of Anti-PD1 Antibody in CHO Cells through Transient Co-Transfection with Anti-Apoptotic Gene Bcl-xL Combined with Rapamycin
Li, Yunxia, Zhang, Xinyu, Wang, Lei, Zong, Huifang, Yuan, Yuan, Han, Lei, Li, Xi, Xu, Chenxiao, Zhang, Jingyi, Zhu, Jianwei, Zhang, Baohong
Published in Processes (01.06.2019)
Published in Processes (01.06.2019)
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Journal Article
POLYPEPTIDE COMBINATION USED FOR TUMOUR IMMUNOTHERAPY, AND PREPARATION METHOD THEREFOR
HAN, Lei, ZONG, Huifang, ZHU, Jianwei, WANG, Jing, XIE, Yueqing, JIANG, Hua, CHEN, Junsheng
Year of Publication 11.10.2023
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Year of Publication 11.10.2023
Patent
POLYPEPTIDE COMBINATION USED FOR TUMOUR IMMUNOTHERAPY, AND PREPARATION METHOD THEREFOR
HAN, Lei, ZONG, Huifang, ZHU, Jianwei, WANG, Jing, XIE, Yueqing, JIANG, Hua, CHEN, Junsheng
Year of Publication 13.10.2022
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Year of Publication 13.10.2022
Patent
POLYPEPTIDE COMBINATION USED FOR TUMOUR IMMUNOTHERAPY, AND PREPARATION METHOD THEREFOR
HAN, Lei, ZONG, Huifang, ZHU, Jianwei, WANG, Jing, XIE, Yueqing, JIANG, Hua, CHEN, Junsheng
Year of Publication 02.03.2022
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Year of Publication 02.03.2022
Patent