Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Peposertib, a DNA-PK Inhibitor, Enhances the Anti-Tumor Efficacy of Topoisomerase II Inhibitors in Triple-Negative Breast Cancer Models
Revia, Steffie, Neumann, Felix, Jabs, Julia, Orio, Florian, Sirrenberg, Christian, Zimmermann, Astrid, Amendt, Christiane, Albers, Joachim
Published in International journal of molecular sciences (08.05.2024)
Published in International journal of molecular sciences (08.05.2024)
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Journal Article
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation
Klein, Carmen, Dokic, Ivana, Mairani, Andrea, Mein, Stewart, Brons, Stephan, Häring, Peter, Haberer, Thomas, Jäkel, Oliver, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree, Debus, Jürgen, Abdollahi, Amir
Published in Radiation oncology (London, England) (29.12.2017)
Published in Radiation oncology (London, England) (29.12.2017)
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Journal Article
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien‐Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish
Published in EMBO molecular medicine (07.08.2023)
Published in EMBO molecular medicine (07.08.2023)
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Journal Article
Author Correction: ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer
Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien-Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Bassel, Laurel L, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish
Published in EMBO molecular medicine (16.02.2024)
Published in EMBO molecular medicine (16.02.2024)
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Journal Article
Exposure-response modeling improves selection of radiation and radiosensitizer combinations
Cardilin, Tim, Almquist, Joachim, Jirstrand, Mats, Zimmermann, Astrid, Lignet, Floriane, El Bawab, Samer, Gabrielsson, Johan
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2022)
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2022)
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Journal Article
Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy
Zenke, Frank T., Zimmermann, Astrid, Dahmen, Heike, Elenbaas, Brian, Pollard, John, Reaper, Philip, Bagrodia, S, Spilker, M E., Amendt, C, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation
Czikora, István, Alli, Abdel, Bao, Hui-Fang, Kaftan, David, Sridhar, Supriya, Apell, Hans-Jürgen, Gorshkov, Boris, White, Richard, Zimmermann, Astrid, Wendel, Albrecht, Pauly-Evers, Meike, Hamacher, Jürg, Garcia-Gabay, Irène, Fischer, Bernhard, Verin, Alexander, Bagi, Zsolt, Pittet, Jean Francois, Shabbir, Waheed, Lemmens-Gruber, Rosa, Chakraborty, Trinad, Lazrak, Ahmed, Matthay, Michael A, Eaton, Douglas C, Lucas, Rudolf
Published in American journal of respiratory and critical care medicine (01.09.2014)
Published in American journal of respiratory and critical care medicine (01.09.2014)
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Journal Article
Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry
Boaru, Sorina Georgiana, Merle, Uta, Uerlings, Ricarda, Zimmermann, Astrid, Weiskirchen, Sabine, Matusch, Andreas, Stremmel, Wolfgang, Weiskirchen, Ralf
Published in BMC neuroscience (20.08.2014)
Published in BMC neuroscience (20.08.2014)
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Journal Article
Abstract 558: M6123, a selective FGFR1 antagonist, demonstrates anti-tumor activity as monotherapy and in combination with chemotherapy in mesothelioma models
Esdar, Christina, Ross, Edith, Sanderson, Michael, Zimmermann, Astrid
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Jo, Ukhyun, Senatorov, Ilya S, Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N, Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W, Thomas, Anish, Zenke, Frank T, Pommier, Yves
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
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Journal Article
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N, Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M, Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W, Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E, Kindrick, Jessica D, Peer, Cody J, Wei, Jun S, Aladjem, Mirit I, Figg, William Douglas, Steinberg, Seth M, Trepel, Jane B, Zenke, Frank T, Pommier, Yves, Khan, Javed, Thomas, Craig J
Published in Cancer cell (12.04.2021)
Published in Cancer cell (12.04.2021)
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Journal Article
The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Jo, Ukhyun, Arakawa, Yasuhiro, Zimmermann, Astrid, Taniyama, Daiki, Mizunuma, Makito, Jenkins, Lisa M., Maity, Tapan K., Kumar, Suresh, Zenke, Frank T., Takebe, Naoko, Pommier, Yves
Published in Molecular cancer therapeutics (02.07.2024)
Published in Molecular cancer therapeutics (02.07.2024)
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Journal Article
Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer therapeutics (05.07.2023)
Published in Molecular cancer therapeutics (05.07.2023)
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Journal Article