Soluble Guanylate Cyclase Stimulators and Activators
Sandner, Peter, Zimmer, Daniel P., Milne, G. Todd, Follmann, Markus, Hobbs, Adrian, Stasch, Johannes-Peter
Published in Handbook of experimental pharmacology (2021)
Published in Handbook of experimental pharmacology (2021)
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Book Chapter
Journal Article
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
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Journal Article
Nitrogen Regulatory Protein C-Controlled Genes of Escherichia coli: Scavenging as a Defense against Nitrogen Limitation
Zimmer, D P, Soupene, E, Lee, H L, Wendisch, V F, Khodursky, A B, Peter, B J, Bender, R A, Kustu, S
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
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Journal Article
Structural Origins of Adenine-Tract Bending
Barbič, Andrej, Zimmer, Daniel P., Crothers, Donald M.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
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Journal Article
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Published in Pharmacology research & perspectives (01.04.2020)
Published in Pharmacology research & perspectives (01.04.2020)
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Journal Article
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
Madden, Kevin T, Askenazi, Manor, Driggers, Edward M, Holtzman, Douglas A, Norman, Thea C, Iverson, Sara, Zimmer, Daniel P, Boers, Mary-Ellen, Blomquist, Paul R, Martinez, Eduardo J, Monreal, Alex W, Feibelman, Toby P, Mayorga, Maria E, Maxon, Mary E, Sykes, Kristie, Tobin, Jenny Vittum, Cordero, Etchell, Salama, Sofie R, Trueheart, Joshua, Royer, John C
Published in Nature biotechnology (01.02.2003)
Published in Nature biotechnology (01.02.2003)
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Journal Article
The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers
Moss, Nicholas G, Riguera, Dorothy A, Solinga, Robert M, Kessler, Marco M, Zimmer, Daniel P, Arendshorst, William J, Currie, Mark G, Goy, Michael F
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
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Journal Article
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Journal Article
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells
Liu, Guang, Shea, Courtney M., Jones, Juli E., Price, Gavrielle M., Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G., Profy, Albert T., Masferrer, Jaime L., Zimmer, Daniel P.
Published in American journal of physiology. Renal physiology (01.10.2020)
Published in American journal of physiology. Renal physiology (01.10.2020)
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Journal Article
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
Hanrahan, John P., Seferovic, Jelena P., Wakefield, James D., Wilson, Phebe J., Chickering, Jennifer G., Jung, Joon, Carlson, Kenneth E., Zimmer, Daniel P., Frelinger, Andrew L., Michelson, Alan D., Morrow, Linda, Hall, Michael, Currie, Mark G., Milne, G. Todd, Profy, Albert T.
Published in Diabetologia (01.04.2020)
Published in Diabetologia (01.04.2020)
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Journal Article
The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P, Silva, Ines A, Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator
Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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Journal Article
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans
Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Journal Article
Genome Image Programs: Visualization and Interpretation of Escherichia coli Microarray Experiments
Zimmer, Daniel P, Paliy, Oleg, Thomas, Brian, Gyaneshwar, Prasad, Kustu, Sydney
Published in Genetics (Austin) (01.08.2004)
Published in Genetics (Austin) (01.08.2004)
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Journal Article
Mo1504 - The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P., Silva, Ines A., Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
TREATMENTS FOR GASTROINTESTINAL DISORDERS
CURRIE MARK G, ZIMMER DANIEL P, CALI BRIAN M, KESSLER MARCO, FRETZEN ANGELIKA
Year of Publication 19.09.2012
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Year of Publication 19.09.2012
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