Soluble Guanylate Cyclase Stimulators and Activators
Sandner, Peter, Zimmer, Daniel P., Milne, G. Todd, Follmann, Markus, Hobbs, Adrian, Stasch, Johannes-Peter
Published in Handbook of experimental pharmacology (2021)
Published in Handbook of experimental pharmacology (2021)
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Book Chapter
Journal Article
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Journal Article
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells
Liu, Guang, Shea, Courtney M., Jones, Juli E., Price, Gavrielle M., Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G., Profy, Albert T., Masferrer, Jaime L., Zimmer, Daniel P.
Published in American journal of physiology. Renal physiology (01.10.2020)
Published in American journal of physiology. Renal physiology (01.10.2020)
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Journal Article
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
Hanrahan, John P., Seferovic, Jelena P., Wakefield, James D., Wilson, Phebe J., Chickering, Jennifer G., Jung, Joon, Carlson, Kenneth E., Zimmer, Daniel P., Frelinger, Andrew L., Michelson, Alan D., Morrow, Linda, Hall, Michael, Currie, Mark G., Milne, G. Todd, Profy, Albert T.
Published in Diabetologia (01.04.2020)
Published in Diabetologia (01.04.2020)
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Journal Article
The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P, Silva, Ines A, Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
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Journal Article
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator
Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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Journal Article
Nitrogen Regulatory Protein C-Controlled Genes of Escherichia coli: Scavenging as a Defense against Nitrogen Limitation
Zimmer, D P, Soupene, E, Lee, H L, Wendisch, V F, Khodursky, A B, Peter, B J, Bender, R A, Kustu, S
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
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Journal Article
Long-term treatment, tolerability, and survival with sub-cutaneous treprostinil for severe pulmonary hypertension
Sadushi-Koliçi, Roela, MD, Skoro-Sajer, Nika, MD, Zimmer, Daniel, MD, Bonderman, Diana, MD, Schemper, Michael, PhD, Klepetko, Walter, MD, Glatz, Jutta, MSc, Jakowitsch, Johannes, PhD, Lang, Irene M., MD
Published in The Journal of heart and lung transplantation (01.07.2012)
Published in The Journal of heart and lung transplantation (01.07.2012)
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Journal Article
Structural Origins of Adenine-Tract Bending
Barbič, Andrej, Zimmer, Daniel P., Crothers, Donald M.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)
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Journal Article
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Published in Pharmacology research & perspectives (01.04.2020)
Published in Pharmacology research & perspectives (01.04.2020)
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Journal Article
Quantitative mass balance, tissue distribution, pharmacokinetics and biotransformation pathway of praliciguat, a clinical-stage sgc stimulator, after oral administration in rats
Banijamali, Ali, Carvalho, Andrew, Wakefield, James, Germano, Peter, Ribadeneira, Maria, Barden, Timothy, Zimmer, Daniel, Masferrer, Jaime, Profy, Albert, Currie, Mark, Milne, Todd
Published in Drug metabolism and pharmacokinetics (01.01.2019)
Published in Drug metabolism and pharmacokinetics (01.01.2019)
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Journal Article
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
Madden, Kevin T, Askenazi, Manor, Driggers, Edward M, Holtzman, Douglas A, Norman, Thea C, Iverson, Sara, Zimmer, Daniel P, Boers, Mary-Ellen, Blomquist, Paul R, Martinez, Eduardo J, Monreal, Alex W, Feibelman, Toby P, Mayorga, Maria E, Maxon, Mary E, Sykes, Kristie, Tobin, Jenny Vittum, Cordero, Etchell, Salama, Sofie R, Trueheart, Joshua, Royer, John C
Published in Nature biotechnology (01.02.2003)
Published in Nature biotechnology (01.02.2003)
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Journal Article
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans
Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Journal Article
Optimization of a tabletop high-repetition-rate soft x-ray laser pumped in double-pulse single-beam grazing incidence
Zimmer, Daniel, Zielbauer, Bernhard, Pittman, Moana, Guilbaud, Olivier, Habib, Jamil, Kazamias, Sophie, Ros, David, Bagnoud, Vincent, Kuehl, Thomas
Published in Optics letters (15.02.2010)
Published in Optics letters (15.02.2010)
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Journal Article
The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers
Moss, Nicholas G, Riguera, Dorothy A, Solinga, Robert M, Kessler, Marco M, Zimmer, Daniel P, Arendshorst, William J, Currie, Mark G, Goy, Michael F
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
Published in Hypertension (Dallas, Tex. 1979) (01.05.2009)
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Journal Article
Diagnostics of SiCOH-Film-Deposition in the Dielectric Barrier Discharge at Atmospheric Pressure
Vinogradov, Igor, Zimmer, Daniel, Lunk, Achim
Published in Plasma processes and polymers (01.04.2007)
Published in Plasma processes and polymers (01.04.2007)
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Journal Article