A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
Zuo, Erwei, Sun, Yidi, Yuan, Tanglong, He, Bingbing, Zhou, Changyang, Ying, Wenqin, Liu, Jing, Wei, Wu, Zeng, Rong, Li, Yixue, Yang, Hui
Published in Nature methods (01.06.2020)
Published in Nature methods (01.06.2020)
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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
Zhou, Haibo, Su, Jinlin, Hu, Xinde, Zhou, Changyang, Li, He, Chen, Zhaorong, Xiao, Qingquan, Wang, Bo, Wu, Wenyan, Sun, Yidi, Zhou, Yingsi, Tang, Cheng, Liu, Fei, Wang, Linhan, Feng, Canbin, Liu, Mingzhe, Li, Sanlan, Zhang, Yifeng, Xu, Huatai, Yao, Haishan, Shi, Linyu, Yang, Hui
Published in Cell (30.04.2020)
Published in Cell (30.04.2020)
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Journal Article
A Cas-embedding strategy for minimizing off-target effects of DNA base editors
Liu, Yajing, Zhou, Changyang, Huang, Shisheng, Dang, Lu, Wei, Yu, He, Jun, Zhou, Yingsi, Mao, Shaoshuai, Tao, Wanyu, Zhang, Yu, Yang, Hui, Huang, Xingxu, Chi, Tian
Published in Nature communications (27.11.2020)
Published in Nature communications (27.11.2020)
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Journal Article
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice
Zhou, Haibo, Liu, Junlai, Zhou, Changyang, Gao, Ni, Rao, Zhiping, Li, He, Hu, Xinde, Li, Changlin, Yao, Xuan, Shen, Xiaowen, Sun, Yidi, Wei, Yu, Liu, Fei, Ying, Wenqin, Zhang, Junming, Tang, Cheng, Zhang, Xu, Xu, Huatai, Shi, Linyu, Cheng, Leping, Huang, Pengyu, Yang, Hui
Published in Nature neuroscience (01.03.2018)
Published in Nature neuroscience (01.03.2018)
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Journal Article
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
Zuo, Erwei, Cai, Yi-Jun, Li, Kui, Wei, Yu, Wang, Bang-An, Sun, Yidi, Liu, Zhen, Liu, Jiwei, Hu, Xinde, Wei, Wei, Huo, Xiaona, Shi, Linyu, Tang, Cheng, Liang, Dan, Wang, Yan, Nie, Yan-Hong, Zhang, Chen-Chen, Yao, Xuan, Wang, Xing, Zhou, Changyang, Ying, Wenqin, Wang, Qifang, Chen, Ren-Chao, Shen, Qi, Xu, Guo-Liang, Li, Jinsong, Sun, Qiang, Xiong, Zhi-Qi, Yang, Hui
Published in Cell research (01.07.2017)
Published in Cell research (01.07.2017)
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Journal Article
Highly efficient base editing in human tripronuclear zygotes
Zhou, Changyang, Zhang, Meiling, Wei, Yu, Sun, Yidi, Sun, Yun, Pan, Hong, Yao, Ning, Zhong, Wanxia, Li, Yixue, Li, Weiping, Yang, Hui, Chen, Zi-jiang
Published in Protein & cell (01.10.2017)
Published in Protein & cell (01.10.2017)
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Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs
Gao, Ni, Hu, Jing, He, Bingbing, Ji, Zhengbang, Hu, Xinde, Huang, Jia, Wei, Yu, Peng, Jianpeng, Wei, Yinghui, Zhou, Yingsi, Shen, Xiaowen, Li, He, Feng, Xue, Xiao, Qingquan, Shi, Linyu, Sun, Yidi, Zhou, Changyang, Zhou, Haibo, Yang, Hui
Published in Nature cell biology (01.01.2021)
Published in Nature cell biology (01.01.2021)
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Journal Article
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos
Wei, Yu, Zhou, Yingsi, Liu, Yajing, Ying, Wenqin, Lv, Ruiming, Zhao, Qimeng, Zhou, Haibo, Zuo, Erwei, Sun, Yidi, Yang, Hui, Zhou, Changyang
Published in Protein & cell (01.09.2021)
Published in Protein & cell (01.09.2021)
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Journal Article
Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors
Zhang, Meiling, Zhou, Changyang, Wei, Yu, Xu, Chunlong, Pan, Hong, Ying, Wenqin, Sun, Yidi, Sun, Yun, Xiao, Qingquan, Yao, Ning, Zhong, Wanxia, Li, Yun, Wu, Keliang, Yuan, Gao, Mitalipov, Shoukhrat, Chen, Zi-Jiang, Yang, Hui
Published in Genome Biology (22.05.2019)
Published in Genome Biology (22.05.2019)
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Journal Article
Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development
Yang, Guang, Zhou, Changyang, Wang, Ran, Huang, Shisheng, Wei, Yu, Yang, Xianfa, Liu, Yajing, Li, Jianan, Lu, Zongyang, Ying, Wenqin, Li, Xiajun, Jing, Naihe, Huang, Xingxu, Yang, Hui, Qiao, Yunbo
Published in Cell reports (Cambridge) (08.01.2019)
Published in Cell reports (Cambridge) (08.01.2019)
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Journal Article
Structure design and performance comparison of large-scale marine sediment microbial fuel cells in lab and real sea as power source to drive monitoring instruments for long-term work
Zhou, Changyang, Fu, Yubin, Zhang, Haoshuang, Chen, Wei, Liu, Zhi, Liu, Zhaohui, Ying, Ming, Zai, Xuerong
Published in Ionics (01.03.2018)
Published in Ionics (01.03.2018)
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Journal Article
Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a
Liu, Yajing, Lou, Sensen, Li, Jinhui, Liu, Yuanhua, Huang, Shisheng, Wei, Yu, Liu, Jikai, Lv, Ruimin, Tang, Junjie, Shen, Zhixin, Sun, Yidi, Huang, Xingxu, Xiong, Zhiqi, Yang, Hui, Zhou, Changyang
Published in Cell discovery (17.09.2024)
Published in Cell discovery (17.09.2024)
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Journal Article
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Zhou, Changyang, Sun, Yidi, Yan, Rui, Liu, Yajing, Zuo, Erwei, Gu, Chan, Han, Linxiao, Wei, Yu, Hu, Xinde, Zeng, Rong, Li, Yixue, Zhou, Haibo, Guo, Fan, Yang, Hui
Published in Nature (London) (01.07.2019)
Published in Nature (London) (01.07.2019)
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Journal Article
Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells
Wu, Leilei, Jiang, Shutan, Shi, Meisong, Yuan, Tanglong, Li, Yaqin, Huang, Pinzheng, Li, Yingqi, Zuo, Erwei, Zhou, Changyang, Sun, Yidi
Published in Genome Biology (11.11.2024)
Published in Genome Biology (11.11.2024)
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Journal Article
A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice
Li, Jinhui, Shen, Zhixin, Liu, Yajing, Yan, Zixiang, Liu, Yuanhua, Lin, Xiang, Tang, Junjie, Lv, Ruimin, Geng, Guannan, Xiong, Zhi-Qi, Zhou, Changyang, Yang, Hui
Published in Molecular therapy (05.07.2023)
Published in Molecular therapy (05.07.2023)
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Journal Article
Composite‐modified anode by MnO2/polypyrrole in marine benthic microbial fuel cells and its electrochemical performance
Chen, Wei, Liu, Zhaohui, Su, Ge, Fu, Yubin, Zai, Xuerong, Zhou, Changyang, Wang, Jian
Published in International journal of energy research (01.05.2017)
Published in International journal of energy research (01.05.2017)
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Journal Article
OS-093 Efficient and heritable elimination of HBV viral antigens in vivo by epigenome editing
Peng, Wenbo, Zhao, Junzheng, Wu, Dai-tze, Mao, Shaoshuai, Wu, Leilei, Sun, Jing, Lv, Ruimin, Sun, Di, Zhang, Bob, Sun, YiDi, Zhou, Changyang
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing
Zhang, He, Pan, Hong, Zhou, Changyang, Wei, Yu, Ying, Wenqin, Li, Shuting, Wang, Guangqin, Li, Chao, Ren, Yifei, Li, Gen, Ding, Xu, Sun, Yidi, Li, Geng-Lin, Song, Lei, Li, Yixue, Yang, Hui, Liu, Zhiyong
Published in Development (Cambridge) (17.10.2018)
Published in Development (Cambridge) (17.10.2018)
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Journal Article
Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics
Fang, Kailun, Li, Qidan, Wei, Yu, Zhou, Changyang, Guo, Wenhui, Shen, Jiaqi, Wu, Ruoxi, Ying, Wenqin, Yu, Lu, Zi, Jin, Zhang, Yuxing, Yang, Hui, Liu, Siqi, Chen, Charlie Degui
Published in Molecular & cellular proteomics (01.01.2021)
Published in Molecular & cellular proteomics (01.01.2021)
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