Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides
Han, Zhenfu, Pinkner, Jerome S, Ford, Bradley, Chorell, Erik, Crowley, Jan M, Cusumano, Corinne K, Campbell, Scott, Henderson, Jeffrey P, Hultgren, Scott J, Janetka, James W
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Journal Article
Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice
GUITON, Pascale S, CUSUMANO, Corinne K, KLINE, Kimberly A, DODSON, Karen W, ZHENFU HAN, JANETKA, James W, HENDERSON, Jeffrey P, CAPARON, Michael G, HULTGREN, Scott J
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Journal Article
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets
Franco, Francisco M., Jones, Darin E., Harris, Peter K.W., Han, Zhenfu, Wildman, Scott A., Jarvis, Cassie M., Janetka, James W.
Published in Bioorganic & medicinal chemistry (15.05.2015)
Published in Bioorganic & medicinal chemistry (15.05.2015)
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Journal Article
Hexakis(4-(N-butylpyridylium))benzene: A Six-Electron Organic Redox System
Han, Zhenfu, Vaid, Thomas P, Rheingold, Arnold L
Published in Journal of organic chemistry (18.01.2008)
Published in Journal of organic chemistry (18.01.2008)
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Journal Article
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer
Han, Zhenfu, Harris, Peter K. W, Jones, Darin E, Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A, Janetka, James W
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Journal Article
Antivirulence C‑Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections
Mydock-McGrane, Laurel, Cusumano, Zachary, Han, Zhenfu, Binkley, Jana, Kostakioti, Maria, Hannan, Thomas, Pinkner, Jerome S, Klein, Roger, Kalas, Vasilios, Crowley, Jan, Rath, Nigam P, Hultgren, Scott J, Janetka, James W
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Treatment and prevention of urinary tract infection with orally active FimH inhibitors
Cusumano, Corinne K, Pinkner, Jerome S, Han, Zhenfu, Greene, Sarah E, Ford, Bradley A, Crowley, Jan R, Henderson, Jeffrey P, Janetka, James W, Hultgren, Scott J
Published in Science translational medicine (16.11.2011)
Published in Science translational medicine (16.11.2011)
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Journal Article
Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists
Han, Zhenfu, Pinkner, Jerome S, Ford, Bradley, Obermann, Robert, Nolan, William, Wildman, Scott A, Hobbs, Doug, Ellenberger, Tom, Cusumano, Corinne K, Hultgren, Scott J, Janetka, James W
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Journal Article
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production
Keeler, Shamus P, Wu, Kangyun, Zhang, Yong, Mao, Dailing, Li, Ming, Iberg, Courtney A, Austin, Stephen R, Glaser, Samuel A, Yantis, Jennifer, Podgorny, Stephanie, Brody, Steven L, Chartock, Joshua R, Han, Zhenfu, Byers, Derek E, Romero, Arthur G, Holtzman, Michael J
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2023)
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2023)
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Journal Article
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology
Damalanka, Vishnu C, Han, Zhenfu, Karmakar, Partha, O’Donoghue, Anthony J, La Greca, Florencia, Kim, Tommy, Pant, Shishir M, Helander, Jonathan, Klefström, Juha, Craik, Charles S, Janetka, James W
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Abstract 2523: Mechanism-based inhibitors of HGFA, matriptase and hepsin for breast cancer treatment
Janetka, James, Han, Zhenfu, Harris, Peter, Wildman, Scott
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
VUV spectrum of Eu2+ doped halophosphates
Zhou, Yingxue, Shu, Rong, Zhang, Xinyi, Shi, Junyan, Han, Zhenfu
Published in Materials science & engineering. B, Solid-state materials for advanced technology (22.12.1999)
Published in Materials science & engineering. B, Solid-state materials for advanced technology (22.12.1999)
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Journal Article
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI
Jarvis, Cassie, Han, Zhenfu, Kalas, Vasilios, Klein, Roger, Pinkner, Jerome S., Ford, Bradley, Binkley, Jana, Cusumano, Corinne K., Cusumano, Zachary, Mydock-McGrane, Laurel, Hultgren, Scott J., Janetka, James W.
Published in ChemMedChem (17.02.2016)
Published in ChemMedChem (17.02.2016)
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Journal Article
Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation
Owusu, Benjamin Y, Thomas, Shantasia, Venukadasula, Phanindra, Han, Zhenfu, Janetka, James W, Galemmo, Jr, Robert A, Klampfer, Lidija
Published in Oncotarget (08.09.2017)
Published in Oncotarget (08.09.2017)
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Journal Article
Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer
Han, Zhenfu, Harris, Peter K. W., Karmakar, Partha, Kim, Tommy, Owusu, Ben Y., Wildman, Scott A., Klampfer, Lidija, Janetka, James W.
Published in ChemMedChem (17.03.2016)
Published in ChemMedChem (17.03.2016)
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Journal Article
DDIS-10. TARGETING HGF/MET IN GBM BY RESTORING SPINT2 FUNCTION
Liu, Fei, Han, Zhenfu, Karmakar, Partha, Li, Tie, Janetka, James W, Lai, Albert
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2016)
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Journal Article
α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer
Han, Zhenfu, Harris, Peter K. W., Karmakar, Partha, Kim, Tommy, Owusu, Ben Y., Wildman, Scott A., Klampfer, Lidija, Janetka, James W.
Published in ChemMedChem (17.03.2016)
Published in ChemMedChem (17.03.2016)
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