RORγt represses Th17 cell IL-10 production to maintain their pathogenicity in inducing intestinal inflammation
Sun, Mingming, He, Chong, Chen, Liang, Yang, Wenjing, Wu, Wei, Chen, Feidi, Cao, Anthony T., Yao, Suxia, Dann, Sara M, Dhar, T. G. Murali, Salter-Cid, Luisa, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Published in The Journal of immunology (1950) (26.11.2018)
Published in The Journal of immunology (1950) (26.11.2018)
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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Lu, Zhonghui, Duan, James J.-W., Xiao, Haiyun, Neels, James, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, An, Yongmi, Yarde, Melissa, Karmakar, Ananta, Vishwakrishnan, Sureshbabu, Baratam, Venkata, Shankarappa, Harisha, Vanteru, Sridhar, Babu, Venkatesh, Basha, Mushkin, Kumar Gupta, Arun, Kumaravel, Selvakumar, Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Abstract CT124: A phase Ib/II study of BMS-813160, a CC chemokine receptor (CCR) 2/5 dual antagonist, in combination with chemotherapy or nivolumab in patients (pts) with advanced pancreatic or colorectal cancer
Le, Dung, Gutierrez, Martin E., Saleh, Mansoor, Chen, Eric, Mallick, Atrayee Basu, Pishvaian, Michael J., Krauss, Jürgen, O'Dwyer, Peter, Garrido-Laguna, Ignacio, Zhao, Qihong, Kippel, Anke, Wang, Xiaoli, Liu, Yali, Pollack, Allyson, Sama, Ashwin, Lenz, Heinz-Josef
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 3760: Preclinical antitumor activity of a CC chemokine receptor (CCR) 2/5 dual antagonist as monotherapy and in combination with immune checkpoint blockade
Zhao, Qihong, Murtaza, Anwar, Bata, Adam, Sun, Wendy, Ho, Ching-Ping, Vuppugalla, Ragini, Cherney, Robert, Stefanski, Kevin, Cao, Z Alexander, Sama, Ashwin, Yang, Arvin, Struthers, Mary, Sanjuan, Miguel, Hunt, John T., Carter, Percy, Salter-Cid, Luisa
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist
Cherney, Robert J., Cornelius, Lyndon A. M., Srivastava, Anurag, Weigelt, Carolyn A., Marcoux, David, Duan, James J-W, Shi, Qing, Batt, Douglas G., Liu, Qingjie, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John, Khan, Javed, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Mathur, Arvind, Li, Sha, Shuster, David, Khandelwal, Purnima, Borowski, Virna, Xie, Jenny, Obermeier, Mary, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H., Dhar, T. G. Murali
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Gong, Hua, Weinstein, David S., Lu, Zhonghui, Duan, James J.-W., Stachura, Sylwia, Haque, Lauren, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Khan, Javed, Camac, Dan, Sack, John S., Pudzianowski, Andrew, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Borowski, Virna, Xie, Jenny H., Sun, Huadong, D'Arienzo, Celia, Dabros, Marta, Galella, Michael A., Wang, Faye, Weigelt, Carolyn A., Zhao, Qihong, Foster, William, Somerville, John E., Salter-Cid, Luisa M., Barrish, Joel C., Carter, Percy H., Dhar, T.G. Murali
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
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Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists – Exploring C6 and C8 SAR using late-stage functionalization
Shi, Qing, Xiao, Zili, Yang, Michael G., Marcoux, David, Cherney, Robert J., Yip, Shiuhang, Li, Peng, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John, Khan, Javed, Ruzanov, Max, Wang, Jinhong, Yarde, Melissa, Ellen Cvijic, Mary, Li, Sha, Shuster, David J., Xie, Jenny, Sherry, Tara, Obermeier, Mary, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Chacko, Silvi, Shu, Yue-Zhong, Khandelwal, Purnima, Hynes, John, Tino, Joseph A., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Dhar, T.G. Murali
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
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Quantification of surrogate monoclonal antibodies in mouse serum using LC–MS/MS
Mehl, John T, Landry, France, Discenza, Lorell, Sleczka, Bogdan, Zhao, Qihong, Shuster, David J, Madia, Priyanka, DasGupta, Ruchira, Rajendran, Surendran, Sun, Huadong, Ciccimaro, Eugene, Olah, Timothy V
Published in Bioanalysis (01.02.2021)
Published in Bioanalysis (01.02.2021)
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Discovery of 2,6–difluorobenzyl ether series of phenyl ((R)–3–phenylpyrrolidin–3–yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists
Duan, James J.-W., Jiang, Bin, Lu, Zhonghui, Stachura, Sylwia, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, Wu, Dauh–Rurng, Yarde, Melissa, Shen, Ding–Ren, Zhao, Qihong, Salter–Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.
Published in Bioorganic & medicinal chemistry letters (01.10.2020)
Published in Bioorganic & medicinal chemistry letters (01.10.2020)
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Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach
Liu, Qingjie, Batt, Douglas G, Weigelt, Carolyn A, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S, Wang, Jinhong, Yarde, Melissa, Li, Sha, Shuster, David J, Xie, Jenny H, Sherry, Tara, Obermeier, Mary T, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Khandelwal, Purnima, Tino, Joseph A, Macor, John E, Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Dhar, T. G. Murali
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2
Yang, Michael G, Xiao, Zili, Zhao, Rulin, Tebben, Andrew J, Wang, Bei, Cherney, Robert J, Batt, Douglas G, Brown, Gregory D, Cvijic, Mary Ellen, Duncia, John V, Gallela, Michael A, Gardner, Daniel S, Khandelwal, Purnima, Malley, Mary F, Pang, Jian, Rose, Anne V, Santella, Joseph B, Sarjeant, Amy A, Xu, Songmei, Mathur, Arvind, Mandlekar, Sandhya, Vuppugalla, Ragini, Zhao, Qihong, Carter, Percy H
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
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Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis
Liu, Qingjie, Xiao, Hai-Yun, Batt, Douglas G, Xiao, Zili, Zhu, Yeheng, Yang, Michael G, Li, Ning, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S, Weigelt, Carolyn A, Wang, Jinhong, Li, Sha, Shuster, David J, Xie, Jenny H, Song, Yunling, Sherry, Tara, Obermeier, Mary T, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Chacko, Silvi, Khandelwal, Purnima, Dudhgaonkar, Shailesh, Rudra, Anjuman, Nagar, Jignesh, Murali, Venkata, Govindarajan, Arun, Denton, Rex, Zhao, Qihong, Meanwell, Nicholas A, Borzilleri, Robert, Dhar, T. G. Murali
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672
Yang, Michael G, Xiao, Zili, Cherney, Robert J, Tebben, Andrew J, Batt, Douglas G, Brown, Gregory D, Chen, Jing, Cvijic, Mary Ellen, Dabros, Marta, Duncia, John V, Galella, Michael, Gardner, Daniel S, Khandelwal, Purnima, Ko, Soo S, Malley, Mary F, Mo, Ruowei, Pang, Jian, Rose, Anne V, Santella, Joseph B, Shi, Hong, Srivastava, Anurag, Traeger, Sarah C, Wang, Bei, Xu, Songmei, Zhao, Rulin, Barrish, Joel C, Mandlekar, Sandhya, Zhao, Qihong, Carter, Percy H
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity
Brown, Gregory D., Shi, Qing, Delucca, George V., Batt, Douglas G., Galella, Michael A., Cvijic, Mary-Ellen, Liu, Rui-Qin, Qiu, Feng, Zhao, Qihong, Barrish, Joel C., Carter, Percy H.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid ModelSummary
Bailey Zwarycz, Adam D. Gracz, Kristina R. Rivera, Ian A. Williamson, Leigh A. Samsa, Josh Starmer, Michael A. Daniele, Luisa Salter-Cid, Qihong Zhao, Scott T. Magness
Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
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Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
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