TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations
Murray, Brion W, Zhai, Dayong, Deng, Wei, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong J, Aloysius, Herve, Rogers, Evan
Published in Molecular cancer therapeutics (01.09.2021)
Published in Molecular cancer therapeutics (01.09.2021)
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Journal Article
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Konopleva, Marina, Contractor, Rooha, Tsao, Twee, Samudio, Ismael, Ruvolo, Peter P., Kitada, Shinichi, Deng, Xingming, Zhai, Dayong, Shi, Yue-Xi, Sneed, Thomas, Verhaegen, Monique, Soengas, Maria, Ruvolo, Vivian R., McQueen, Teresa, Schober, Wendy D., Watt, Julie C., Jiffar, Tilahun, Ling, Xiaoyang, Marini, Frank C., Harris, David, Dietrich, Martin, Estrov, Zeev, McCubrey, James, May, W. Stratford, Reed, John C., Andreeff, Michael
Published in Cancer cell (01.11.2006)
Published in Cancer cell (01.11.2006)
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Journal Article
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
Lee, Hyunmi, Rotolo, Jimmy A, Mesicek, Judith, Penate-Medina, Tuula, Rimner, Andreas, Liao, Wen-Chieh, Yin, Xianglei, Ragupathi, Govind, Ehleiter, Desiree, Gulbins, Erich, Zhai, Dayong, Reed, John C, Haimovitz-Friedman, Adriana, Fuks, Zvi, Kolesnick, Richard
Published in PloS one (13.06.2011)
Published in PloS one (13.06.2011)
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Journal Article
Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins
Kitada, Shinichi, Leone, Marilisa, Sareth, Sina, Zhai, Dayong, Reed, John C, Pellecchia, Maurizio
Published in Journal of medicinal chemistry (25.09.2003)
Published in Journal of medicinal chemistry (25.09.2003)
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Journal Article
Humanin peptide suppresses apoptosis by interfering with Bax activation
Reed, John C, Guo, Bin, Zhai, Dayong, Cabezas, Edelmira, Welsh, Kate, Nouraini, Shahrzad, Satterthwait, Arnold C
Published in Nature (London) (22.05.2003)
Published in Nature (London) (22.05.2003)
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Journal Article
Vaccinia Virus Virulence Factor N1L is a Novel Promising Target for Antiviral Therapeutic Intervention
Cheltsov, Anton V, Aoyagi, Mika, Aleshin, Alexander, Yu, Eric Chi-Wang, Gilliland, Taylor, Zhai, Dayong, Bobkov, Andrey A, Reed, John C, Liddington, Robert C, Abagyan, Ruben
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Journal Article
Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member
Askari, Nadav, Correa, Ricardo G., Zhai, Dayong, Reed, John C.
Published in Journal of biotechnology (01.01.2012)
Published in Journal of biotechnology (01.01.2012)
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Journal Article
Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization
Faustin, Benjamin, Chen, Ya, Zhai, Dayong, Negrate, Gaelle Le, Lartigue, Lydia, Satterthwait, Arnold, Reed, John C
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
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Journal Article
Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors
Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Cui, J. Jean
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins
Zhai, Dayong, Jin, Chaofang, Shiau, Chung-Wai, Kitada, Shinichi, Satterthwait, Arnold C, Reed, John C
Published in Molecular cancer therapeutics (01.06.2008)
Published in Molecular cancer therapeutics (01.06.2008)
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Journal Article
Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4): Autophagins (Atg4)
Shu, Chih-Wen, Drag, Marcin, Bekes, Miklos, Zhai, Dayong, Salvesen, Guy S., Reed, John C.
Published in Autophagy (01.10.2010)
Published in Autophagy (01.10.2010)
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Journal Article
Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
Wei, Jun, Kitada, Shinichi, Rega, Michele F, Stebbins, John L, Zhai, Dayong, Cellitti, Jason, Yuan, Hongbin, Emdadi, Aras, Dahl, Russell, Zhang, Ziming, Yang, Li, Reed, John C, Pellecchia, Maurizio
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Journal Article
Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak
Zhai, Dayong, Luciano, Frederic, Zhu, Xiuwen, Guo, Bin, Satterthwait, Arnold C., Reed, John C.
Published in The Journal of biological chemistry (22.04.2005)
Published in The Journal of biological chemistry (22.04.2005)
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Journal Article
Regulation of p53 Localization and Activity by Ubc13
Laine, Aaron, Topisirovic, Ivan, Zhai, Dayong, Reed, John C., Borden, Katherine L. B., Ronai, Ze'ev
Published in Molecular and Cellular Biology (01.12.2006)
Published in Molecular and Cellular Biology (01.12.2006)
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Journal Article
High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4
Shu, Chih-Wen, Madiraju, Charitha, Zhai, Dayong, Welsh, Kate, Diaz, Paul, Sergienko, Eduard, Sano, Renata, Reed, John C
Published in Journal of biomolecular screening (01.02.2011)
Published in Journal of biomolecular screening (01.02.2011)
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Journal Article
Structure-Activity Relationships by Interligand NOE-Based Design and Synthesis of Antiapoptotic Compounds Targeting Bid
Becattini, Barbara, Culmsee, Carsten, Leone, Marilisa, Zhai, Dayong, Zhang, Xiyun, Crowell, Kevin J., Rega, Michele F., Landshamer, Stefan, Reed, John C., Plesnila, Nikolaus, Pellecchia, Maurizio
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2006)
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Journal Article
Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor
Zhai, Dayong, Yu, Eric, Jin, Chaofang, Welsh, Kate, Shiau, Chung-wei, Chen, Lili, Salvesen, Guy S., Liddington, Robert, Reed, John C.
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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