Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
Luciano, Frederic, Krajewska, Maryla, Ortiz-Rubio, Paulina, Krajewski, Stan, Zhai, Dayong, Faustin, Benjamin, Bruey, Jean-Marie, Bailly-Maitre, Beatrice, Lichtenstein, Alan, Kolluri, Siva Kumar, Satterthwait, Arnold C., Zhang, Xiao-Kun, Reed, John C.
Published in Blood (01.05.2007)
Published in Blood (01.05.2007)
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Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
Lee, Hyunmi, Rotolo, Jimmy A, Mesicek, Judith, Penate-Medina, Tuula, Rimner, Andreas, Liao, Wen-Chieh, Yin, Xianglei, Ragupathi, Govind, Ehleiter, Desiree, Gulbins, Erich, Zhai, Dayong, Reed, John C, Haimovitz-Friedman, Adriana, Fuks, Zvi, Kolesnick, Richard
Published in PloS one (30.12.2015)
Published in PloS one (30.12.2015)
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Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
Luciano, Frederic, Zhai, Dayong, Zhu, Xiuwen, Bailly-Maitre, Beatrice, Ricci, Jean-Ehrland, Satterthwait, Arnold C., Reed, John C.
Published in The Journal of biological chemistry (22.04.2005)
Published in The Journal of biological chemistry (22.04.2005)
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Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins
Wei, Jun, Kitada, Shinichi, Rega, Michele F, Emdadi, Aras, Yuan, Hongbin, Cellitti, Jason, Stebbins, John L, Zhai, Dayong, Sun, Jiazhi, Yang, Li, Dahl, Russell, Zhang, Ziming, Wu, Bainan, Wang, Si, Reed, Tyler A, Wang, Hong-Gang, Lawrence, Nicholas, Sebti, Said, Reed, John C, Pellecchia, Maurizio
Published in Molecular cancer therapeutics (01.04.2009)
Published in Molecular cancer therapeutics (01.04.2009)
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Inhibition of Bfl-1 with N-aryl maleimides
Cashman, John R., MacDonald, Mary, Ghirmai, Senait, Okolotowicz, Karl J., Sergienko, Eduard, Brown, Brock, Garcia, Xochella, Zhai, Dayong, Dahl, Russell, Reed, John C.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies
Krajewska, Maryla, Kitada, Shinichi, Winter, Jane N, Variakojis, Daina, Lichtenstein, Alan, Zhai, Dayong, Cuddy, Michael, Huang, Xianshu, Luciano, Frederic, Baker, Cheryl H, Kim, Hoguen, Shin, Eunah, Kennedy, Susan, Olson, Allen H, Badzio, Andrzej, Jassem, Jacek, Meinhold-Heerlein, Ivo, Duffy, Michael J, Schimmer, Aaron D, Tsao, Ming, Brown, Ewan, Sawyers, Anne, Andreeff, Michael, Mercola, Dan, Krajewski, Stan, Reed, John C
Published in Clinical cancer research (15.05.2008)
Published in Clinical cancer research (15.05.2008)
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Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins
Hassig, Christian A, Zeng, Fu-Yue, Kung, Paul, Kiankarimi, Mehrak, Kim, Sylvia, Diaz, Paul W, Zhai, Dayong, Welsh, Kate, Morshedian, Shana, Su, Ying, O'Keefe, Barry, Newman, David J, Rusman, Yudi, Kaur, Harneet, Salomon, Christine E, Brown, Susan G, Baire, Beeraiah, Michel, Andrew R, Hoye, Thomas R, Francis, Subhashree, Georg, Gunda I, Walters, Michael A, Divlianska, Daniela B, Roth, Gregory P, Wright, Amy E, Reed, John C
Published in Journal of biomolecular screening (01.09.2014)
Published in Journal of biomolecular screening (01.09.2014)
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Journal Article
High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1
Zhai, Dayong, Godoi, Paulo, Sergienko, Eduard, Dahl, Russell, Chan, Xochella, Brown, Brock, Rascon, Justin, Hurder, Andrew, Su, Ying, Chung, Thomas D Y, Jin, Chaofang, Diaz, Paul, Reed, John C
Published in Journal of biomolecular screening (01.03.2012)
Published in Journal of biomolecular screening (01.03.2012)
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Conformation of Membrane-associated Proapoptotic tBid
Gong, Xiao-Min, Choi, Jungyuen, Franzin, Carla M, Zhai, Dayong, Reed, John C, Marassi, Francesca M
Published in The Journal of biological chemistry (09.07.2004)
Published in The Journal of biological chemistry (09.07.2004)
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Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations
Drilon, Alexander, Ou, Sai-Hong Ignatius, Cho, Byoung Chul, Kim, Dong-Wan, Lee, Jeeyun, Lin, Jessica J, Zhu, Viola W, Ahn, Myung-Ju, Camidge, D Ross, Nguyen, Judy, Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Liu, Juliet, Whitten, Jeff, Lim, John K, Stopatschinskaja, Shanna, Hyman, David M, Doebele, Robert C, Cui, J Jean, Shaw, Alice T
Published in Cancer discovery (01.10.2018)
Published in Cancer discovery (01.10.2018)
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Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations
Murray, Brion W, Rogers, Evan, Zhai, Dayong, Deng, Wei, Chen, Xi, Sprengeler, Paul A, Zhang, Xin, Graber, Armin, Reich, Siegfried H, Stopatschinskaja, Shanna, Solomon, Benjamin, Besse, Benjamin, Drilon, Alexander
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract 1444: TPX-0022, a potent MET/SRC/CSF1R inhibitor that modulates the tumor immune microenvironment in preclinical models
Goel, Vikas K., Deng, Wei, zhai, Dayong, Lee, Nathan V., Parra, Ana, Murray, Brion W.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1958: Repotrectinib increases effectiveness of KRAS-G12C inhibitors in KRAS-G12C mutant cancer models via simultaneous SRC/FAK/JAK2 inhibition
Cui, J. Jean, Zhai, Dayong, Deng, Wei, Rodon, Laura, Lee, Nathan, Murray, Brion
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 1957: Repotrectinib increases effectiveness of MEK inhibitor trametinib in KRAS mutant cancer models via simultaneous SRC/FAK/JAK2 inhibition
Murray, Brion, Deng, Wei, Zhai, Dayong, Rodon, Laura, Lee, Nathan, Cui, J. Jean
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 1104: Repotrectinib increases effectiveness of MEK inhibitors in KRAS mutant cancer models
Lee, Nathan V., Deng, Wei, Zhai, Dayong, Rodon, Laura, Parra, Ana, Cowell, Jessica, Banisadr, Afsheen, Zhang, Xin, Murray, Brion W.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1119: Molecular characteristics of repotrectinib that enable potent inhibition of TRK fusion proteins and broad mutant selectivity
Drilon, Alexander, Zhai, Dayong, Rogers, Evan, Deng, Wei, Chen, Xi, Sprengeler, Paul, Reich, Siegfried H., Murray, Brion W.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 3168: Overcoming acquired drug resistance by TPX-0005, an ALK, ROS1 and pan-TRK inhibitor
Deng, Wei, Huang, John, Zhai, Dayong, Rogers, Evan, Cui, Jean
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 1319: Repotrectinib, a new generation ROS1 inhibitor, is highly potent against fusion ROS1s and emerging resistance mutations
Deng, Wei, Zhai, Dayong, Zhang, Xin, Lee, Dong, Rogers, Evan, Whitten, Jeffrey, Cui, J. Jean
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 1469: TPX-0131, a potent inhibitor of wild type ALK and a broad spectrum of both single and compound ALK resistance mutations
Murray, Brion W., Zhai, Dayong, Deng, Wei, Rogers, Evan, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong, Aloysius, Herve
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 4796: Ropotrectinib is a novel polypharmacology kinase inhibitor against WT and mutant ROS1, TRK and ALK
Deng, Wei, Zhai, Dayong, Huang, John, Rogers, Evan, Whitten, Jeffrey, Lim, John, Li, Yishan, Cui, Jean
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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