Extracellular and intracellular small-molecule galectin-3 inhibitors
Stegmayr, John, Zetterberg, Fredrik, Carlsson, Michael C, Huang, Xiaoli, Sharma, Gunjan, Kahl-Knutson, Barbro, Schambye, Hans, Nilsson, Ulf J, Oredsson, Stina, Leffler, Hakon
Published in Scientific reports (18.02.2019)
Published in Scientific reports (18.02.2019)
Get full text
Journal Article
Discovery and Optimization of the First Highly Effective and Orally Available Galectin‑3 Inhibitors for Treatment of Fibrotic Disease
Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
Get full text
Journal Article
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade
Vuong, Lynda, Kouverianou, Eleni, Rooney, Claire M, McHugh, Brian J, Howie, Sarah E M, Gregory, Christopher D, Forbes, Stuart J, Henderson, Neil C, Zetterberg, Fredrik R, Nilsson, Ulf J, Leffler, Hakon, Ford, Paul, Pedersen, Anders, Gravelle, Lise, Tantawi, Susan, Schambye, Hans, Sethi, Tariq, MacKinnon, Alison C
Published in Cancer research (Chicago, Ill.) (01.04.2019)
Published in Cancer research (Chicago, Ill.) (01.04.2019)
Get full text
Journal Article
N‐BAR and F‐BAR proteins—endophilin‐A3 and PSTPIP1—control clathrin‐independent endocytosis of L1CAM
Lemaigre, Camille, Ceuppens, Apolline, Valades‐Cruz, Cesar Augusto, Ledoux, Benjamin, Vanbeneden, Bastien, Hassan, Mujtaba, Zetterberg, Fredrik R., Nilsson, Ulf J., Johannes, Ludger, Wunder, Christian, Renard, Henri‐François, Morsomme, Pierre
Published in Traffic (Copenhagen, Denmark) (01.04.2023)
Published in Traffic (Copenhagen, Denmark) (01.04.2023)
Get full text
Journal Article
Discovery of Selective and Orally Available Galectin‑1 Inhibitors
Zetterberg, Fredrik R., Diehl, Carl, Håkansson, Maria, Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Peterson, Kristoffer, Roper, James A., Slack, Robert J.
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
Get full text
Journal Article
Monosaccharide Derivatives with Low‐Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine–Amide, Phenyl–Arginine, Sulfur–π, and Halogen Bond Interactions
Zetterberg, Fredrik R., Peterson, Kristoffer, Johnsson, Richard E., Brimert, Thomas, Håkansson, Maria, Logan, Derek T., Leffler, Hakon, Nilsson, Ulf J.
Published in ChemMedChem (22.01.2018)
Published in ChemMedChem (22.01.2018)
Get full text
Journal Article
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Published in Frontiers in immunology (28.08.2023)
Published in Frontiers in immunology (28.08.2023)
Get full text
Journal Article
Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders
Published in Journal of medicinal chemistry (28.05.2024)
Published in Journal of medicinal chemistry (28.05.2024)
Get full text
Journal Article
Myocardin related transcription factor and galectin-3 drive lipid accumulation in human blood vessels
Arévalo-Martinez, Marycarmen, Ede, Jacob, van der Have, Oscar, Ritsvall, Olivia, Zetterberg, Fredrik R., Nilsson, Ulf J., Leffler, Hakon, Holmberg, Johan, Albinsson, Sebastian
Published in Vascular pharmacology (01.09.2024)
Published in Vascular pharmacology (01.09.2024)
Get full text
Journal Article
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Kim, Henry, Kretz, Louis, Ronin, Céline, Starck, Christina, Roper, James A, Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J, Pedersen, Anders, Zetterberg, Fredrik R, Slack, Robert J
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
Get full text
Journal Article
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
Dahlqvist, Alexander, Zetterberg, Fredrik R, Leffler, Hakon, Nilsson, Ulf J
Published in MedChemComm (01.06.2019)
Published in MedChemComm (01.06.2019)
Get full text
Journal Article
Relative bioavailability and food effect of the galectin-3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA-1)
Aslanis, Vassilios, Abd-Elaziz, Khalid, Slack, Robert J, Brinch, Anne, Gravelle, Lise, Morley, Wayne, Phung, De, Herman, Kimberly, Holyer, Ian, Poulsen, Karen Killerup, Dogterom, Peter, Tantawi, Susan, Zetterberg, Fredrik R, Jacoby, Brian, Schambye, Hans, Lindmark, Bertil
Published in Cancer chemotherapy and pharmacology (21.08.2024)
Published in Cancer chemotherapy and pharmacology (21.08.2024)
Get full text
Journal Article
In Vivo Veritas: 18F‑Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin‑3 Inhibitors
Bratteby, Klas, Torkelsson, Edvard, L’Estrade, Elina Tampio, Peterson, Kristoffer, Shalgunov, Vladimir, Xiong, Mengfei, Leffler, Hakon, Zetterberg, Fredrik R, Olsson, Tomas G, Gillings, Nic, Nilsson, Ulf J, Herth, Matthias M, Erlandsson, Maria
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
Get full text
Journal Article
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
Pal, Kumar Bhaskar, Mahanti, Mukul, Huang, Xiaoli, Persson, Stella, Sundin, Anders P., Zetterberg, Fredrik R., Oredsson, Stina, Leffler, Hakon, Nilsson, Ulf J.
Published in Organic & biomolecular chemistry (2018)
Published in Organic & biomolecular chemistry (2018)
Get full text
Journal Article
The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Comeglio, Paolo, Guarnieri, Giulia, Filippi, Sandra, Cellai, Ilaria, Acciai, Gabriele, Holyer, Ian, Zetterberg, Fredrik, Leffler, Hakon, Kahl-Knutson, Barbro, Sarchielli, Erica, Morelli, Annamaria, Maggi, Mario, Slack, Robert J., Vignozzi, Linda
Published in Frontiers in pharmacology (31.07.2024)
Published in Frontiers in pharmacology (31.07.2024)
Get full text
Journal Article
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
Kim, Seok-Jun, Kang, Hyeok-Gu, Kim, Kyungeun, Kim, Hoyoung, Zetterberg, Fredrik, Park, Young Soo, Cho, Hyun-Soo, Hewitt, Stephen M., Chung, Joon-Yong, Nilsson, Ulf J., Leffler, Hakon, Chun, Kyung-Hee
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.09.2021)
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.09.2021)
Get full text
Journal Article
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
Dahlqvist, Alexander, Mandal, Santanu, Peterson, Kristoffer, Håkansson, Maria, Logan, Derek T, Zetterberg, Fredrik R, Leffler, Hakon, Nilsson, Ulf J
Published in Molecules (Basel, Switzerland) (12.12.2019)
Published in Molecules (Basel, Switzerland) (12.12.2019)
Get full text
Journal Article
In Vivo Veritas : 18 F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
Bratteby, Klas, Torkelsson, Edvard, L'Estrade, Elina Tampio, Peterson, Kristoffer, Shalgunov, Vladimir, Xiong, Mengfei, Leffler, Hakon, Zetterberg, Fredrik R, Olsson, Tomas G, Gillings, Nic, Nilsson, Ulf J, Herth, Matthias M, Erlandsson, Maria
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
Get full text
Journal Article
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
Peterson, Kristoffer, Collins, Patrick M, Huang, Xiaoli, Kahl-Knutsson, Barbro, Essén, Sofia, Zetterberg, Fredrik R, Oredsson, Stina, Leffler, Hakon, Blanchard, Helen, Nilsson, Ulf J
Published in RSC advances (01.01.2018)
Published in RSC advances (01.01.2018)
Get full text
Journal Article
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
Kim, Henry, Weidner, Nathalie, Ronin, Céline, Klein, Emmanuel, Roper, James A., Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Zetterberg, Fredrik R., Slack, Robert J.
Published in SLAS discovery (01.07.2023)
Published in SLAS discovery (01.07.2023)
Get full text
Journal Article