Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814
Sun, Qing, Guo, Yige, Liu, Xiaohong, Czauderna, Frank, Carr, Michael I, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer research (01.12.2019)
Published in Molecular cancer research (01.12.2019)
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Journal Article
Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Jo, Ukhyun, Senatorov, Ilya S, Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N, Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W, Thomas, Anish, Zenke, Frank T, Pommier, Yves
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
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Journal Article
A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N, Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M, Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W, Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E, Kindrick, Jessica D, Peer, Cody J, Wei, Jun S, Aladjem, Mirit I, Figg, William Douglas, Steinberg, Seth M, Trepel, Jane B, Zenke, Frank T, Pommier, Yves, Khan, Javed, Thomas, Craig J
Published in Cancer cell (12.04.2021)
Published in Cancer cell (12.04.2021)
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Journal Article
Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer therapeutics (05.07.2023)
Published in Molecular cancer therapeutics (05.07.2023)
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Journal Article
A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice
Roidos, Paris, Sungalee, Stephanie, Benfatto, Salvatore, Serçin, Özdemirhan, Stütz, Adrian M, Abdollahi, Amir, Mauer, Jan, Zenke, Frank T, Korbel, Jan O, Mardin, Balca R
Published in Nature communications (14.08.2020)
Published in Nature communications (14.08.2020)
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Journal Article
Mapping combinatorial drug effects to DNA damage response kinase inhibitors
Zhang, Hanrui, Kreis, Julian, Schelhorn, Sven-Eric, Dahmen, Heike, Grombacher, Thomas, Zühlsdorf, Michael, Zenke, Frank T, Guan, Yuanfang
Published in Nature communications (14.12.2023)
Published in Nature communications (14.12.2023)
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Journal Article
Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death
Chiu, Li-Ya, Sun, Qing, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Aging (Albany, NY.) (17.01.2023)
Published in Aging (Albany, NY.) (17.01.2023)
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Journal Article
The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Jo, Ukhyun, Arakawa, Yasuhiro, Zimmermann, Astrid, Taniyama, Daiki, Mizunuma, Makito, Jenkins, Lisa M, Maity, Tapan, Kumar, Suresh, Zenke, Frank T, Takebe, Naoko, Pommier, Yves
Published in Molecular cancer therapeutics (02.07.2024)
Published in Molecular cancer therapeutics (02.07.2024)
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Journal Article
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
Haines, Eric, Nishida, Yuki, Carr, Michael I, Montoya, Rafael Heinz, Ostermann, Lauren B, Zhang, Weiguo, Zenke, Frank T, Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T
Published in Scientific reports (09.06.2021)
Published in Scientific reports (09.06.2021)
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Journal Article
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitors
Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Blume, Beatrix, Bomke, Jörg, Calderini, Michel, Eckert, Uwe, Friese-Hamim, Manja, Kohl, Rainer, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Rohdich, Felix, Zenke, Frank T
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Journal Article
Modeling the Effect of Hypoxia and DNA Repair Inhibition on Cell Survival After Photon Irradiation
Liew, Hans, Klein, Carmen, Zenke, Frank T, Abdollahi, Amir, Debus, Jürgen, Dokic, Ivana, Mairani, Andrea
Published in International journal of molecular sciences (30.11.2019)
Published in International journal of molecular sciences (30.11.2019)
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Journal Article
Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality
Benfatto, Salvatore, Serçin, Özdemirhan, Dejure, Francesca R, Abdollahi, Amir, Zenke, Frank T, Mardin, Balca R
Published in Molecular cancer (28.08.2021)
Published in Molecular cancer (28.08.2021)
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Journal Article
Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer
Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Becker, Frank, Blume, Beatrix, Bomke, Jörg, Dietz, Melanie, Eckert, Uwe, Friese-Hamim, Manja, Gunera, Jakub, Hansen, Kerrin, Leuthner, Birgitta, Musil, Djordje, Pfalzgraf, Jens, Rohdich, Felix, Siegl, Christian, Spuck, Dieter, Wegener, Ansgar, Zenke, Frank T
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Journal Article
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien‐Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish
Published in EMBO molecular medicine (07.08.2023)
Published in EMBO molecular medicine (07.08.2023)
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Journal Article
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation
Klein, Carmen, Dokic, Ivana, Mairani, Andrea, Mein, Stewart, Brons, Stephan, Häring, Peter, Haberer, Thomas, Jäkel, Oliver, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree, Debus, Jürgen, Abdollahi, Amir
Published in Radiation oncology (London, England) (29.12.2017)
Published in Radiation oncology (London, England) (29.12.2017)
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Journal Article
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Llorca-Cardenosa, Marta J, Aronson, Lauren I, Krastev, Dragomir B, Nieminuszczy, Jadwiga, Alexander, John, Song, Feifei, Dylewska, Malgorzata, Broderick, Ronan, Brough, Rachel, Zimmermann, Astrid, Zenke, Frank T, Gurel, Bora, Riisnaes, Ruth, Ferreira, Ana, Roumeliotis, Theodoros, Choudhary, Jyoti, Pettitt, Stephen J, de Bono, Johann, Cervantes, Andres, Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J, Chong, Irene Y
Published in Cancer research (Chicago, Ill.) (02.11.2022)
Published in Cancer research (Chicago, Ill.) (02.11.2022)
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Journal Article
The Role of ATR Inhibitors in Ovarian Cancer: Investigating Predictive Biomarkers of Response
Bradbury, Alice, Zenke, Frank T., Curtin, Nicola J., Drew, Yvette
Published in Cells (Basel, Switzerland) (01.08.2022)
Published in Cells (Basel, Switzerland) (01.08.2022)
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