Computational Predictions of Nonclinical Pharmacokinetics at the Drug Design Stage
Stoyanova, Raya, Katzberger, Paul Maximilian, Komissarov, Leonid, Khadhraoui, Aous, Sach-Peltason, Lisa, Groebke Zbinden, Katrin, Schindler, Torsten, Manevski, Nenad
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Published in Journal of chemical information and modeling (23.01.2023)
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Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Ferragud, Antonio, Velázquez-Sánchez, Clara, Sotnikova, Tatyana D, Morairty, Stephen R, Harmeier, Anja, Groebke Zbinden, Katrin, Norcross, Roger D, Bradaia, Amyaouch, Kilduff, Thomas S, Biemans, Barbara, Pouzet, Bruno, Caron, Marc G, Canales, Juan J, Wallace, Tanya L, Wettstein, Joseph G, Hoener, Marius C
Published in Biological psychiatry (1969) (01.12.2012)
Published in Biological psychiatry (1969) (01.12.2012)
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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike
Published in Bioorganic & medicinal chemistry (01.08.2006)
Published in Bioorganic & medicinal chemistry (01.08.2006)
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Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate
Anselm, Lilli, Banner, David W., Benz, Jörg, Groebke Zbinden, Katrin, Himber, Jacques, Hilpert, Hans, Huber, Walter, Kuhn, Bernd, Mary, Jean-Luc, Otteneder, Michael B., Panday, Narendra, Ricklin, Fabienne, Stahl, Martin, Thomi, Stefan, Haap, Wolfgang
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Journal Article
Discovery and Characterization of 2‑Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido, Beurier, Angélica, Décoret, Guillaume, Goergler, Annick, Hutter, Roman, Mohr, Susanne, Pähler, Axel, Schmid, Philipp, Türck, Dietrich, Unger, Robert, Zbinden, Katrin Groebke, Hoener, Marius C, Norcross, Roger D
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
Zbinden, Katrin Groebke, Anselm, Lilli, Banner, David W., Benz, Jörg, Blasco, Francesca, Décoret, Guillaume, Himber, Jacques, Kuhn, Bernd, Panday, Narendra, Ricklin, Fabienne, Risch, Philippe, Schlatter, Daniel, Stahl, Martin, Thomi, Stefan, Unger, Robert, Haap, Wolfgang
Published in European journal of medicinal chemistry (01.07.2009)
Published in European journal of medicinal chemistry (01.07.2009)
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Journal Article
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors
Groebke Zbinden, Katrin, Banner, David W., Ackermann, Jean, D’Arcy, Allan, Kirchhofer, Daniel, Ji, Yu-Hua, Tschopp, Thomas B., Wallbaum, Sabine, Weber, Lutz
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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GALLEY, Guido, GROEBKE ZBINDEN, Katrin, GUBA, Wolfgang, HUNZIKER, Daniel
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent
CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES
GALLEY, Guido, GROEBKE ZBINDEN, Katrin, GUBA, Wolfgang, HUNZIKER, Daniel
Year of Publication 29.03.2023
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Year of Publication 29.03.2023
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BENZIMIDAZOLE PYRIDINE DERIVATIVES
KREIS, Lukas, LUK, Kin-Chun Thomas, GROEBKE ZBINDEN, Katrin, HAAP, Wolfgang, MISCHKE, Steven Gregory, PFLIEGER, Philippe
Year of Publication 07.11.2024
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Year of Publication 07.11.2024
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IMPROVED CANCER IMMUNOTHERAPY
SCHMIDT, Tobias, GROEBKE ZBINDEN, Katrin, MURGIA, Claudio, UMAÑA, Pablo, GASSER, Stephan, SORRENTINO, Antonio
Year of Publication 06.06.2024
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Year of Publication 06.06.2024
Patent