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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formation
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Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Bhattacharya, Samit K., Aspnes, Gary E., Bagley, Scott W., Boehm, Markus, Brosius, Arthur D., Buckbinder, Leonard, Chang, Jeanne S., Dibrino, Joseph, Eng, Heather, Frederick, Kosea S., Griffith, David A., Griffor, Matthew C., Guimarães, Cristiano R.W., Guzman-Perez, Angel, Han, Seungil, Kalgutkar, Amit S., Klug-McLeod, Jacquelyn, Garcia-Irizarry, Carmen, Li, Jianke, Lippa, Blaise, Price, David A., Southers, James A., Walker, Daniel P., Wei, Liuqing, Xiao, Jun, Zawistoski, Michael P., Zhao, Xumiao
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Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: Retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry
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Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Discovery of CP-533536 : An EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation
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Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Short-acting 5-(trifluoromethyl)pyrido[4,3- d]pyrimidin-4(3 H)-one derivatives as orally-active calcium-sensing receptor antagonists
Didiuk, Mary T., Griffith, David A., Benbow, John W., Liu, Kevin K.C., Walker, Daniel P., Christopher Bi, F., Morris, Joel, Guzman-Perez, Angel, Gao, Hua, Bechle, Bruce M., Kelley, Ryan M., Yang, Xiaojing, Dirico, Kenneth, Ahmed, Syed, Hungerford, William, DiBrinno, Joseph, Zawistoski, Michael P., Bagley, Scott W., Li, Jianke, Zeng, Yuan, Santucci, Stephanie, Oliver, Robert, Corbett, Matthew, Olson, Thanh, Chen, Chiliu, Li, Mei, Paralkar, Vishwas M., Riccardi, Keith A., Healy, David R., Kalgutkar, Amit S., Maurer, Tristan S., Nguyen, Hang T., Frederick, Kosea S.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists
Chesworth, Richard, Zawistoski, Michael P., Lefker, Bruce A., Cameron, Kimberly O., Day, Robert F., Mangano, F.Michael, Rosati, Robert L., Colella, Stacy, Petersen, Donna N., Brault, Amy, Lu, Bihong, Pan, Lydia C., Perry, Pia, Ng, Oicheng, Castleberry, Tessa A., Owen, Thomas A., Brown, Thomas A., Thompson, David D., DaSilva-Jardine, Paul
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats
Cameron, Kimberly O., Lefker, Bruce A., Chu-Moyer, Margaret Y., Crawford, David T., Jardine, Paul DaSilva, DeNinno, Shari L., Gilbert, Sandra, Grasser, William A., Ke, HuaZhu, Lu, Bihong, Owen, Thomas A., Paralkar, Vishwas M., Qi, Hong, Scott, Dennis O., Thompson, David D., Tjoa, Christina M., Zawistoski, Michael P.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs): Discovery of capromorelin
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Published in Bioorganic & medicinal chemistry (20.02.2003)
Published in Bioorganic & medicinal chemistry (20.02.2003)
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Discovery and biological characterization of capromorelin analogues with extended half-lives
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Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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11-Ketotigogenin Cellobioside (Pamaqueside): A Potent Cholesterol Absorption Inhibitor in the Hamster
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Published in Journal of medicinal chemistry (10.05.1996)
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Published in Tetrahedron letters (30.12.2009)
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