Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
Iketani, Sho, Forouhar, Farhad, Liu, Hengrui, Hong, Seo Jung, Lin, Fang-Yu, Nair, Manoj S, Zask, Arie, Huang, Yaoxing, Xing, Li, Stockwell, Brent R, Chavez, Alejandro, Ho, David D
Published in Nature communications (01.04.2021)
Published in Nature communications (01.04.2021)
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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
Liu, Hengrui, Iketani, Sho, Zask, Arie, Khanizeman, Nisha, Bednarova, Eva, Forouhar, Farhad, Fowler, Brandon, Hong, Seo Jung, Mohri, Hiroshi, Nair, Manoj S, Huang, Yaoxing, Tay, Nicholas E S, Lee, Sumin, Karan, Charles, Resnick, Samuel J, Quinn, Colette, Li, Wenjing, Shion, Henry, Xia, Xin, Daniels, Jacob D, Bartolo-Cruz, Michelle, Farina, Marcelo, Rajbhandari, Presha, Jurtschenko, Christopher, Lauber, Matthew A, McDonald, Thomas, Stokes, Michael E, Hurst, Brett L, Rovis, Tomislav, Chavez, Alejandro, Ho, David D, Stockwell, Brent R
Published in Nature communications (07.04.2022)
Published in Nature communications (07.04.2022)
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Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents
Bos, Pieter H., Lowry, Emily R., Costa, Jonathon, Thams, Sebastian, Garcia-Diaz, Alejandro, Zask, Arie, Wichterle, Hynek, Stockwell, Brent R.
Published in Cell chemical biology (19.12.2019)
Published in Cell chemical biology (19.12.2019)
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Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
KER YU, TORAL-BARZA, Lourdes, COLE, Derek C, ELLINGBOE, John, AYRAL-KALOUSTIAN, Semiramis, MANSOUR, Tarek S, GIBBONS, James J, ABRAHAM, Robert T, NOWAK, Pawel, ZASK, Arie, SHI, Celine, ZHANG, Wei-Guo, LUCAS, Judy, SHOR, Boris, KIM, Jamie, VERHEIJEN, Jeroen, CURRAN, Kevin, MALWITZ, David J
Published in Cancer research (Chicago, Ill.) (01.08.2009)
Published in Cancer research (Chicago, Ill.) (01.08.2009)
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Author Correction: Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
Iketani, Sho, Forouhar, Farhad, Liu, Hengrui, Hong, Seo Jung, Lin, Fang-Yu, Nair, Manoj S, Zask, Arie, Huang, Yaoxing, Xing, Li, Stockwell, Brent R, Chavez, Alejandro, Ho, David D
Published in Nature communications (05.05.2021)
Published in Nature communications (05.05.2021)
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Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
KER YU, SHI, Celine, SUNG KYOO KIM, CONANT, Roger, CURRAN, Kevin, KAPLAN, Joshua, VERHEIJEN, Jeroen, AYRAL-KALOUSTIAN, Semiramis, MANSOUR, Tarek S, ABRAHAM, Robert T, ZASK, Arie, GIBBONS, James J, TORAL-BARZA, Lourdes, LUCAS, Judy, SHOR, Boris, JAE EUN KIM, ZHANG, Wei-Guo, MAHONEY, Robert, GAYDOS, Christine, TARDIO, Luanna
Published in Cancer research (Chicago, Ill.) (15.01.2010)
Published in Cancer research (Chicago, Ill.) (15.01.2010)
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Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
KAPLAN, Joshua, VERHEIJEN, Jeroen C, BROOIJMANS, Natasja, TORAL-BARZA, Lourdes, HOLLANDER, Irwin, YU, Ker, ZASK, Arie
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin−Rapamycin Conjugates
Ayral-Kaloustian, Semiramis, Gu, Jianxin, Lucas, Judy, Cinque, Michael, Gaydos, Christine, Zask, Arie, Chaudhary, Inder, Wang, Jianyao, Di, Li, Young, Mairead, Ruppen, Mark, Mansour, Tarek S, Gibbons, James J, Yu, Ker
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies
Niu, Chuansheng, Ho, Douglas M., Zask, Arie, Ayral-Kaloustian, Semiramis
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Yu, Ker, Lucas, Judy, Zhu, Tianmin, Zask, Arie, Gaydos, Christine, Toral-Barza, Lourdes, Gu, Jianxin, Li, Fangbiao, Chaudhary, Inder, Cai, Ping, Lotvin, Jason, Petersen, Roseann, Ruppen, Mark, Fawzi, Mahdi, Ayral-Kaloustian, Semiramis, Skotnicki, Jerauld, Mansour, Tarek, Frost, Philip, Gibbons, James
Published in Cancer biology & therapy (01.05.2005)
Published in Cancer biology & therapy (01.05.2005)
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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design
Chen, James M, Nelson, Frances C, Levin, Jeremy I, Mobilio, Dominick, Moy, Franklin J, Nilakantan, Ramaswamy, Zask, Arie, Powers, Robert
Published in Journal of the American Chemical Society (11.10.2000)
Published in Journal of the American Chemical Society (11.10.2000)
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Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in α-tubulin
Loganzo, Frank, Hari, Malathi, Annable, Tami, Tan, Xingzhi, Morilla, Daniel B, Musto, Sylvia, Zask, Arie, Kaplan, Joshua, Minnick, Jr, Albert A, May, Michael K, Ayral-Kaloustian, Semiramis, Poruchynsky, Marianne S, Fojo, Tito, Greenberger, Lee M
Published in Molecular cancer therapeutics (01.10.2004)
Published in Molecular cancer therapeutics (01.10.2004)
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Multivalent Small-Molecule Pan-RAS Inhibitors
Welsch, Matthew E., Kaplan, Anna, Chambers, Jennifer M., Stokes, Michael E., Bos, Pieter H., Zask, Arie, Zhang, Yan, Sanchez-Martin, Marta, Badgley, Michael A., Huang, Christine S., Tran, Timothy H., Akkiraju, Hemanth, Brown, Lewis M., Nandakumar, Renu, Cremers, Serge, Yang, Wan Seok, Tong, Liang, Olive, Kenneth P., Ferrando, Adolfo, Stockwell, Brent R.
Published in Cell (23.02.2017)
Published in Cell (23.02.2017)
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Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
Stokes, Michael E., Vasciaveo, Alessandro, Small, Jonnell Candice, Zask, Arie, Reznik, Eduard, Smith, Nailah, Wang, Qian, Daniels, Jacob, Forouhar, Farhad, Rajbhandari, Presha, Califano, Andrea, Stockwell, Brent R.
Published in Cell chemical biology (18.04.2024)
Published in Cell chemical biology (18.04.2024)
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