Glucolipotoxicity of the pancreatic beta cell
Poitout, Vincent, Amyot, Julie, Semache, Meriem, Zarrouki, Bader, Hagman, Derek, Fontés, Ghislaine
Published in Biochimica et biophysica acta (01.03.2010)
Published in Biochimica et biophysica acta (01.03.2010)
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Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats
Moullé, Valentine S., Vivot, Kevin, Tremblay, Caroline, Zarrouki, Bader, Ghislain, Julien, Poitout, Vincent
Published in Diabetologia (01.05.2017)
Published in Diabetologia (01.05.2017)
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Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation
Soulage, Christophe O., Sardón Puig, Laura, Soulère, Laurent, Zarrouki, Bader, Guichardant, Michel, Lagarde, Michel, Pillon, Nicolas J.
Published in Diabetologia (01.03.2018)
Published in Diabetologia (01.03.2018)
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Journal Article
The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes
Kilic, Gamze, Alvarez-Mercado, Ana I, Zarrouki, Bader, Opland, Darren, Liew, Chong Wee, Alonso, Laura C, Myers, Jr, Martin G, Jonas, Jean-Christophe, Poitout, Vincent, Kulkarni, Rohit N, Mauvais-Jarvis, Franck
Published in PloS one (03.02.2014)
Published in PloS one (03.02.2014)
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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets
Vivot, Kevin, Moullé, Valentine S, Zarrouki, Bader, Tremblay, Caroline, Mancini, Arturo D, Maachi, Hasna, Ghislain, Julien, Poitout, Vincent
Published in Molecular metabolism (Germany) (01.10.2016)
Published in Molecular metabolism (Germany) (01.10.2016)
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The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice
Fontés, Ghislaine, Ghislain, Julien, Benterki, Isma, Zarrouki, Bader, Trudel, Dominique, Berthiaume, Yves, Poitout, Vincent
Published in Diabetes (New York, N.Y.) (01.12.2015)
Published in Diabetes (New York, N.Y.) (01.12.2015)
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193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats
KROON, TOBIAS, HAGSTEDT, THERESE, ALEXANDERSSON, IDA, FERM, ANNETT, PETERSSON, MARIE, MAURER, STEFANIE, ZARROUKI, BADER, WALLENIUS, KRISTINA, OAKES, NICHOLAS D., BOUCHER, JEREMIE
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats
Kroon, Tobias, Hagstedt, Therese, Alexandersson, Ida, Ferm, Annett, Petersson, Marie, Maurer, Stefanie, Zarrouki, Bader, Wallenius, Kristina, Oakes, Nicholas D, Boucher, Jeremie
Published in Science translational medicine (26.10.2022)
Published in Science translational medicine (26.10.2022)
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Journal Article
Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
ZARROUKI, Bader, BENTERKI, Isma, FONTES, Ghislaine, PEYOT, Marie-Line, SEDA, Ondrej, PRENTKI, Marc, POITOUT, Vincent
Published in Diabetes (New York, N.Y.) (01.03.2014)
Published in Diabetes (New York, N.Y.) (01.03.2014)
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Journal Article
Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation
Vella, Roxane E, Pillon, Nicolas J, Zarrouki, Bader, Croze, Marine L, Koppe, Laetitia, Guichardant, Michel, Pesenti, Sandra, Chauvin, Marie-Agnès, Rieusset, Jennifer, Géloën, Alain, Soulage, Christophe O
Published in Diabetes (New York, N.Y.) (01.03.2015)
Published in Diabetes (New York, N.Y.) (01.03.2015)
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Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation
O’Mahony, Gavin, Petersen, Jens, Ek, Margareta, Rae, Rebecca, Johansson, Carina, Jianming, Liu, Prokoph, Nina, Bergström, Fredrik, Bamberg, Krister, Giordanetto, Fabrizio, Zarrouki, Bader, Karlsson, Daniel, Hogner, Anders
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
PEYOT, Marie-Line, PEPIN, Emilie, PRENTKI, Marc, LAMONTAGNE, Julien, LATOUR, Martin G, ZARROUKI, Bader, LUSSIER, Roxane, PINEDA, Marco, JETTON, Thomas L, MURTHY MADIRAJU, S. R, JOLY, Erik
Published in Diabetes (New York, N.Y.) (01.09.2010)
Published in Diabetes (New York, N.Y.) (01.09.2010)
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Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis
Salignon, Jérôme, Faridani, Omid R, Miliotis, Tasso, Janssens, Georges E, Chen, Ping, Zarrouki, Bader, Sandberg, Rickard, Davidsson, Pia, Riedel, Christian G
Published in Aging (Albany, NY.) (20.06.2023)
Published in Aging (Albany, NY.) (20.06.2023)
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The [Delta]F508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional [Beta]-Cell Mass in Mice
Fontés, Ghislaine, Ghislain, Julien, Benterki, Isma, Zarrouki, Bader, Trudel, Dominique, Berthiaume, Yves, Poitout, Vincent
Published in Diabetes (New York, N.Y.) (01.12.2015)
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Published in Diabetes (New York, N.Y.) (01.12.2015)
Journal Article
Epidermal Growth Factor Receptor Signaling Promotes Pancreatic [Beta]-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
Zarrouki, Bader, Benterki, Isma, Fontés, Ghislaine, Peyot, Marie-Line, Seda, Ondrej, Prentki, Marc, Poitout, Vincent
Published in Diabetes (New York, N.Y.) (01.03.2014)
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Published in Diabetes (New York, N.Y.) (01.03.2014)
Journal Article
Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells
Semache, Meriem, Zarrouki, Bader, Fontés, Ghislaine, Fogarty, Sarah, Kikani, Chintan, Chawki, Mohammad B., Rutter, Jared, Poitout, Vincent
Published in The Journal of biological chemistry (23.08.2013)
Published in The Journal of biological chemistry (23.08.2013)
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Journal Article
Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells
SABATINI, Paul V, KRENTZ, Nicole A. J, ZARROUKI, Bader, WESTWELL-ROPER, Clara Y, CUILAN NIAN, UY, Ryan A, SHAPIRO, A. M. James, POITOUT, Vincent, LYNN, Francis C
Published in Diabetes (New York, N.Y.) (01.08.2013)
Published in Diabetes (New York, N.Y.) (01.08.2013)
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Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
Nag, Abhishek, Dhindsa, Ryan S, Mitchell, Jonathan, Vasavda, Chirag, Harper, Andrew R, Vitsios, Dimitrios, Ahnmark, Andrea, Bilican, Bilada, Madeyski-Bengtson, Katja, Zarrouki, Bader, Zoghbi, Anthony W, Wang, Quanli, Smith, Katherine R, Alegre-Díaz, Jesus, Kuri-Morales, Pablo, Berumen, Jaime, Tapia-Conyer, Roberto, Emberson, Jonathan, Torres, Jason M, Collins, Rory, Smith, David M, Challis, Benjamin, Paul, Dirk S, Bohlooly-Y, Mohammad, Snowden, Mike, Baker, David, Fritsche-Danielson, Regina, Pangalos, Menelas N, Petrovski, Slavé
Published in Science advances (16.11.2022)
Published in Science advances (16.11.2022)
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