Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer
Gomez‐Roca, Carlos, Even, Caroline, Le Tourneau, Christophe, Basté, Neus, Delord, Jean‐Pierre, Sarini, Jerome, Vergez, Sebastien, Temam, Stephane, Hoffmann, Caroline, Rochaix, Philippe, Borcoman, Edith, Gavillet, Bruno, Rouits, Elisabeth, Ménétrey, Annick, Brichory, Franck, Purcea, Daniela, Vuagniaux, Gregoire, Zanna, Claudio
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
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Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl- l-carnitine
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Published in European journal of cancer (1990) (01.08.2005)
Published in European journal of cancer (1990) (01.08.2005)
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Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties
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Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer
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Published in Clinical cancer research (15.09.2007)
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Conference Proceeding
A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations
Voss, Martin H, Hierro, Cinta, Heist, Rebecca S, Cleary, James M, Meric-Bernstam, Funda, Tabernero, Josep, Janku, Filip, Gandhi, Leena, Iafrate, A John, Borger, Darrell R, Ishii, Nobuya, Hu, Youyou, Kirpicheva, Yulia, Nicolas-Metral, Valerie, Pokorska-Bocci, Anna, Vaslin Chessex, Anne, Zanna, Claudio, Flaherty, Keith T, Baselga, Jose
Published in Clinical cancer research (01.05.2019)
Published in Clinical cancer research (01.05.2019)
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Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
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Published in The lancet oncology (01.09.2020)
Published in The lancet oncology (01.09.2020)
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Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
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Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
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The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma
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Published in Radiotherapy and oncology (01.09.2015)
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TrilynX: A phase 3 trial of xevinapant and concurrent chemoradiation for locally advanced head and neck cancer
Bourhis, Jean, Burtness, Barbara, Licitra, Lisa F., Nutting, Christopher, Schoenfeld, Jonathan D., Ait Sarkouh, Rafik, Bouisset, Florilene, Nauwelaerts, Heidi, Urfer, Yulia, Zanna, Claudio, Cohen, Ezra E.W.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design
Bourhis, Jean, Burtness, Barbara, Licitra, Lisa F, Nutting, Christopher, Schoenfeld, Jonathan D, Omar, Mokhtar, Bouisset, Florilene, Nauwelaerts, Heidi, Urfer, Yulia, Zanna, Claudio, Cohen, Ezra Ew
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Published in Future oncology (London, England) (01.05.2022)
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FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma
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Year of Publication 28.06.2022
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Year of Publication 28.06.2022
Patent
FUZE clinical trial: a phase 2 study of Debio 1347 in FGFR fusion-positive advanced solid tumors irrespectively of tumor histology
Hyman, David Michael, Goyal, Lipika, Grivas, Petros, Meric-Bernstam, Funda, Tabernero, Josep, Hu, Youyou, Kirpicheva, Yulia, Nicolas-Metral, Valerie, Pokorska-Bocci, Anna, Vaslin, Anne, Zanna, Claudio, Flaherty, Keith
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Grivas, Petros, Garralda, Elena, Meric-Bernstam, Funda, Mellinghoff, Ingo K, Goyal, Lipika, Harding, James J, Dees, E Claire, Bahleda, Rastislav, Azad, Nilofer S, Karippot, Asha, Kurzrock, Razelle, Tabernero, Josep, Kononen, Juha, Ng, Matthew C H, Mehta, Rutika, Uboha, Nataliya V, Bigot, Frédéric, Boni, Valentina, Bowyer, Samantha E, Breder, Valeriy, Cervantes, Andres, Chan, Nancy, Cleary, James M, Dhawan, Mallika, Eefsen, Rikke L, Ewing, James, Graham, Donna M, Guren, Tormod K, Won Kim, Jin, Koynov, Krassimir, Oh, Do-Youn, Redman, Rebecca, Yen, Chia-Jui, Spetzler, David, Roubaudi-Fraschini, Marie-Claude, Nicolas-Metral, Valerie, Ait-Sarkouh, Rafik, Zanna, Claudio, Ennaji, Abdallah, Pokorska-Bocci, Anna, Flaherty, Keith T
Published in Clinical cancer research (21.05.2024)
Published in Clinical cancer research (21.05.2024)
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Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study
Hurwitz, Herbert I., Smith, David C., Pitot, Henry C., Brill, Jeffrey M., Chugh, Rashmi, Rouits, Elisabeth, Rubin, Joseph, Strickler, John, Vuagniaux, Gregoire, Sorensen, J. Mel, Zanna, Claudio
Published in Cancer chemotherapy and pharmacology (01.04.2015)
Published in Cancer chemotherapy and pharmacology (01.04.2015)
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Chemotherapy-induced peripheral neurotoxicity can be misdiagnosed by the National Cancer Institute Common Toxicity scale
Frigeni, Barbara, Piatti, Marialuisa, Lanzani, Francesca, Alberti, Paola, Villa, Patrizia, Zanna, Claudio, Ceracchi, Maurizio, Ildebrando, Massimo, Cavaletti, Guido
Published in Journal of the peripheral nervous system (01.09.2011)
Published in Journal of the peripheral nervous system (01.09.2011)
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The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the National Cancer Institute-Common Toxicity Scale
Cavaletti, Guido, Frigeni, Barbara, Lanzani, Francesca, Piatti, Marialuisa, Rota, Stefania, Briani, Chiara, Zara, Gabriella, Plasmati, Rosaria, Pastorelli, Francesca, Caraceni, Augusto, Pace, Andrea, Manicone, Mariagrazia, Lissoni, Andrea, Colombo, Nicoletta, Bianchi, Giulia, Zanna, Claudio
Published in Journal of the peripheral nervous system (01.09.2007)
Published in Journal of the peripheral nervous system (01.09.2007)
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Abstract 5001: Open-label, non-randomized, exploratory pre-operative window-of-opportunity trial to investigate the pharmacokinetics and pharmacodynamics of the smac mimetic Debio 1143 in patients with resectable squamous cell carcinoma of the head and neck
Gomez-Roca, Carlos, Even, Caroline, Tourneau, Christophe Le, Rotllan, Neus Basté, Delord, Jean-Pierre, Sarini, Jerome, Vergez, Sebastien, Teman, Stephane, Hoffmann, Caroline, Rochaix, Philippe, Gavillet, Bruno, Rouits, Elisabeth, Brichory, Franck, Rechavi-Robinson, Dalit, Bize, Vincent, Rizzo, Sebastien Del, Purcea, Daniela, Brienza, Silvano, Zanna, Claudio, Vuagniaux, Gregoire, Szyldergemajn, Sergio
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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