ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies
Zammarchi, Francesca, Corbett, Simon, Adams, Lauren, Tyrer, Peter C., Kiakos, Konstantinos, Janghra, Narinder, Marafioti, Teresa, Britten, Charles E., Havenith, Carin E.G., Chivers, Simon, D'Hooge, Francois, Williams, David G., Tiberghien, Arnaud, Howard, Philip W., Hartley, John A., van Berkel, Patrick H.
Published in Blood (08.03.2018)
Published in Blood (08.03.2018)
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Journal Article
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Published in Scientific reports (11.07.2018)
Published in Scientific reports (11.07.2018)
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Journal Article
Antitumorigenic potential of STAT3 alternative splicing modulation
Zammarchi, Francesca, de Stanchina, Elisa, Bournazou, Eirini, Supakorndej, Teerawit, Martires, Kathryn, Riedel, Elyn, Corben, Adriana D., Bromberg, Jacqueline F., Cartegni, Luca
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2011)
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Journal Article
CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity
Zammarchi, Francesca, Havenith, Karin, Bertelli, Francois, Vijayakrishnan, Balakumar, Chivers, Simon, van Berkel, Patrick H
Published in Journal for immunotherapy of cancer (01.09.2020)
Published in Journal for immunotherapy of cancer (01.09.2020)
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Journal Article
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf
Published in Nature communications (22.09.2021)
Published in Nature communications (22.09.2021)
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Journal Article
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
Flynn, Michael J, Zammarchi, Francesca, Tyrer, Peter C, Akarca, Ayse U, Janghra, Narinder, Britten, Charles E, Havenith, Carin E G, Levy, Jean-Noel, Tiberghien, Arnaud, Masterson, Luke A, Barry, Conor, D'Hooge, Francois, Marafioti, Teresa, Parren, Paul W H I, Williams, David G, Howard, Philip W, van Berkel, Patrick H, Hartley, John A
Published in Molecular cancer therapeutics (01.11.2016)
Published in Molecular cancer therapeutics (01.11.2016)
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Journal Article
621 A Tregs depleting, CD25-targeted antibody-drug conjugate synergizes with tumor-targeted radiotherapy and systemic interleukin-2 in pre-clinical models of solid cancers
Berkel, Patrick van, Zammarchi, Francesca
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Targeting CD19-positive lymphomas with the antibody-drug conjugate loncastuximab tesirine: preclinical evidence as single agent and in combination therapy
Tarantelli, Chiara, Wald, David, Munz, Nicolas, Spriano, Filippo, Bruscaggin, Alessio, Cannas, Eleonora, Cascione, Luciano, Gaudio, Eugenio, Arribas, Alberto J, Manjappa, Shivaprasad, Golino, Gaetanina, Scalise, Lorenzo, Cacciapuoti, Maria Teresa, Zucca, Emanuele, Stathis, Anastasios, Inghirami, Giorgio, Van Berkel, Patrick H, Rossi, Davide, Caimi, Paolo F, Zammarchi, Francesca, Bertoni, Francesco
Published in Haematologica (Roma) (09.05.2024)
Published in Haematologica (Roma) (09.05.2024)
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Journal Article
In relapsed or refractory diffuse large B‐cell lymphoma, CD19 expression by immunohistochemistry alone is not a predictor of response to loncastuximab tesirine
Caimi, Paolo F., Hamadani, Mehdi, Carlo‐Stella, Carmelo, Nickaeen, Masoud, Jordie, Eric, Utsey, Kiersten, Knab, Tim, Zammarchi, Francesca, Cucchi, Danilo, Pantano, Serafino, Havenith, Karin, Wang, Ying, Boni, Joseph
Published in EJHaem (01.02.2024)
Published in EJHaem (01.02.2024)
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Journal Article
Targeted DNA Damage Boost with Loncastuximab Tesirine in Combination with PARP Inhibitors in Diffuse Large B-Cell Lymphoma
Fusani, Stefania, Rossi, Alessandra, Mazzara, Saveria, Baiardi, Elena, Orecchioni, Stefania, Talarico, Giovanna, Falvo, Paolo, Zammarchi, Francesca, Van Berkel, Patrick, Pileri, Stefano A., Bertolini, Francesco, Tarella, Corrado, Derenzini, Enrico
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate
Murray, Elizabeth R., Brown, Nicholas F., Howard, Philip, Masterson, Luke, Zammarchi, Francesca, van Berkel, Patrick H., Marshall, John F.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
CD19 Expression by IHC Alone Is Not a Predictor of Response to Loncastuximab Tesirine: Results from the LOTIS-2 Clinical Trial and Quantitative Systems Pharmacology Modeling
Caimi, Paolo F., Hamadani, Mehdi, Carlo-Stella, Carmelo, Nickaeen, Masoud, Jordie, Eric, Utsey, Kiersten, Knab, Tim, Zammarchi, Francesca, Pantano, Serafino, Havenith, Karin, Wang, Ying, Boni, Joseph
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Targeting CD25+ lymphoma cells with the antibody-drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents
Spriano, Filippo, Tarantelli, Chiara, Cascione, Luciano, Gaudio, Eugenio, Golino, Gaetanina, Scalise, Lorenzo, Cacciapuoti, Maria Teresa, Zucca, Emanuele, Stathis, Anastasios, Van Berkel, Patrick H, Inghirami, Giorgio, Zammarchi, Francesca, Bertoni, Francesco
Published in British journal of haematology (30.07.2024)
Published in British journal of haematology (30.07.2024)
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Journal Article