Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications
Li, James J, Sutton, James C, Nirschl, Alexandra, Zou, Yan, Wang, Haixia, Sun, Chongqing, Pi, Zulan, Johnson, Rebecca, Krystek, Stanley R, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Fura, Aberra, Vyas, Viral P, Li, Cindy Y, Gougoutas, Jack Z, Galella, Michael A, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
Simpkins, Ligaya M., Bolton, Scott, Pi, Zulan, Sutton, James C., Kwon, Chet, Zhao, Guohua, Magnin, David R., Augeri, David J., Gungor, Timur, Rotella, David P., Sun, Zhong, Liu, Yajun, Slusarchyk, William S., Marcinkeviciene, Jovita, Robertson, James G., Wang, Aiying, Robl, Jeffrey A., Atwal, Karnail S., Zahler, Robert L., Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors
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Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase
BISACCHI, Gregory S, SLUSARCHYK, William A, TREUNER, Uwe, ZAHLER, Robert, GUOHUA ZHAO, SEILER, Steven M, BOLTON, Scott A, HARTL, Karen S, JACOBS, Glenn, MATHUR, Arvind, WEI MENG, OGLETREE, Martin L, ZULAN PI, SUTTON, James C
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7
Marineau, Jason J, Hamman, Kristin B, Hu, Shanhu, Alnemy, Sydney, Mihalich, Janessa, Kabro, Anzhelika, Whitmore, Kenneth Matthew, Winter, Dana K, Roy, Stephanie, Ciblat, Stephane, Ke, Nan, Savinainen, Anneli, Wilsily, Ashraf, Malojcic, Goran, Zahler, Robert, Schmidt, Darby, Bradley, Michael J, Waters, Nigel J, Chuaqui, Claudio
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Total synthesis of the polyether antibiotic ionomycin
Evans, David A, Dow, Robert L, Shih, Thomas L, Takacs, James M, Zahler, Robert
Published in Journal of the American Chemical Society (01.06.1990)
Published in Journal of the American Chemical Society (01.06.1990)
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T-타입 칼슘 채널 길항제 및 이의 용도
WANG XINNAN, VANHAUWAERT ROELAND, BHARAT VINITA, NGUYEN DAVID, ZAHLER ROBERT
Year of Publication 07.12.2023
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Year of Publication 07.12.2023
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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N
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Published in Journal of medicinal chemistry (13.03.2008)
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Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC–MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition
Turnpenny, Paul, Padfield, Anthony, Barton, Patrick, Teague, Joanne, Rahme, Laurence G., Pucci, Michael J., Zahler, Robert, Rubio, Aileen
Published in Journal of pharmaceutical and biomedical analysis (30.05.2017)
Published in Journal of pharmaceutical and biomedical analysis (30.05.2017)
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Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance
Maura, Damien, Drees, Steffen L, Bandyopadhaya, Arunava, Kitao, Tomoe, Negri, Michele, Starkey, Melissa, Lesic, Biliana, Milot, Sylvain, Déziel, Eric, Zahler, Robert, Pucci, Mike, Felici, Antonio, Fetzner, Susanne, Lépine, François, Rahme, Laurence G
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Published in ACS chemical biology (19.05.2017)
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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O'Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Jr, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T W
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A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194
Singh, Janak, Bisacchi, Gregory S, Ahmad, Saleem, Godfrey, Jollie D, Kissick, Thomas P, Mitt, Toomas, Kocy, Octavian, Vu, Truc, Papaioannou, Chris G, Wong, Michael K, Heikes, James E, Zahler, Robert, Mueller, Richard H
Published in Organic process research & development (01.11.1998)
Published in Organic process research & development (01.11.1998)
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THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
ZHOU DING, CAI ZHENWEI, TRAVINS JEREMY M, KONTEATIS ZENON D, POPOVICI MULLER JANETA, ZAHLER ROBERT
Year of Publication 07.03.2022
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Year of Publication 07.03.2022
Patent
Optimization of Activity, Selectivity, and Liability Profiles in 5-0xopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichloropheny1)-2-methyl5-oxo-5H-pyrrolo(3,4-b)pyridin-6(7H)-y1)-N,N-dimethylacetamide (BMS-767778)
Devasthale, Pratik, Wang, Ying, Wang, Wei, Fevig, John, Feng, JianXin, Wang, Aiying, Harrity, Tom, Egan, Don, Morgan, Nathan, Cap, Michael, Fura, Aberra, Klei, Herbert E., Kish, Kevin, Weigelt, Carolyn, Sun, Lucy, Levesque, Paul, Moulin, Frederic, Li, Yi-Xin, Zahler, Robert, Kirby, Mark S., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
Brigance, Robert P., Meng, Wei, Fura, Aberra, Harrity, Thomas, Wang, Aiying, Zahler, Robert, Kirby, Mark S., Hamann, Lawrence G.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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인간 인테그린 A4B7 억제
CUI DAN, LIN FU YANG, KIM BYUNGCHAN, BURSAVICH MATTHEW G, ROGERS BRUCE N, TROAST DAWN M, HOUANG EVELYNE, KONZE KYLE D, LIPPA BLAISE S, RAFI SALMA, ZAHLER ROBERT, DOWLING JAMES E, HICKEY EUGENE, HARRISON BRYCE A, GERASYUTO ALEKSEY I, DAY TYLER, HAHN KRISTOPHER N, ZHONG CHENG
Year of Publication 19.06.2023
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Year of Publication 19.06.2023
Patent
Optimization of Activity, Selectivity, and Liability Profiles in 5‑Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)‑2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo‑5H‑pyrrolo[3,4‑b]pyridin-6(7H)‑yl)‑N,N‑dimethylacetamide (BMS-767778)
Devasthale, Pratik, Wang, Ying, Wang, Wei, Fevig, John, Feng, JianXin, Wang, Aiying, Harrity, Tom, Egan, Don, Morgan, Nathan, Cap, Michael, Fura, Aberra, Klei, Herbert E, Kish, Kevin, Weigelt, Carolyn, Sun, Lucy, Levesque, Paul, Moulin, Frederic, Li, Yi-Xin, Zahler, Robert, Kirby, Mark S, Hamann, Lawrence G
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
Zhang, Hao, Ding, Charles Z., Lai, Zhi, Chen, Sean S., Devasthale, Pratik, Herpin, Tim, Morton, George, Qu, Fucheng, Ryono, Denis, Smirk, Rebecca, Wang, Wei, Wu, Shung, Ye, Xiang-Xang, Li, Yi-Xin, Apedo, Atsu, Farrelly, Dennis, Wang, Tao, Gu, Liqun, Morgan, Nathan, Flynn, Neil, Chu, Cuixia, Kunselman, Lori, Lippy, Jonathan, Locke, Kenneth, O’Malley, Kevin, Harrity, Thomas, Cap, Michael, Zhang, Lisa, Hosagrahara, Vinayak, Kadiyala, Pathanjali, Xu, Carrie, Doweyko, Arthur M., Zahler, Robert, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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