Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
Zhou, Meixia, Crawford, Yongping, Ng, Domingos, Tung, Jack, Pynn, Abigail F.J., Meier, Angela, Yuk, Inn H., Vijayasankaran, Natarajan, Leach, Kimberly, Joly, John, Snedecor, Bradley, Shen, Amy
Published in Journal of biotechnology (20.04.2011)
Published in Journal of biotechnology (20.04.2011)
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Journal Article
Culture temperature modulates aggregation of recombinant antibody in cho cells
Gomez, Natalia, Subramanian, Jayashree, Ouyang, Jun, Nguyen, Mary D.H., Hutchinson, Matthew, Sharma, Vikas K., Lin, Andy A., Yuk, Inn H.
Published in Biotechnology and bioengineering (01.01.2012)
Published in Biotechnology and bioengineering (01.01.2012)
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Journal Article
Formulation mitigations for particle formation induced by enzymatic hydrolysis of polysorbate 20 in protein-based drug products: insights from a full-factorial longitudinal study
Yuk, Inn H., Koulis, Theo, Doshi, Nidhi, Gregoritza, Kathrin, Hediger, Constanze, Lebouc-Haefliger, Vanessa, Giddings, Jamie, Khan, Tarik A.
Published in AAPS open (01.12.2022)
Published in AAPS open (01.12.2022)
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Journal Article
Characterization of Recombinantly-Expressed Hydrolytic Enzymes from Chinese Hamster Ovary Cells: Identification of Host Cell Proteins that Degrade Polysorbate
Kovner, Daniel, Yuk, Inn H., Shen, Amy, Li, Hong, Graf, Tobias, Gupta, Sanjay, Liu, Wenqiang, Tomlinson, Anthony
Published in Journal of pharmaceutical sciences (01.05.2023)
Published in Journal of pharmaceutical sciences (01.05.2023)
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Journal Article
Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation
Graf, Tobias, Tomlinson, Anthony, Yuk, Inn H., Kufer, Regina, Spensberger, Bernhard, Falkenstein, Roberto, Shen, Amy, Li, Hong, Duan, Dana, Liu, Wenqiang, Wohlrab, Stefanie, Edelmann, Franziska, Leiss, Michael
Published in Journal of pharmaceutical sciences (01.11.2021)
Published in Journal of pharmaceutical sciences (01.11.2021)
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Journal Article
High-Throughput, Fluorescence-Based Esterase Activity Assay for Assessing Polysorbate Degradation Risk during Biopharmaceutical Development
Bhargava, Adithi C., Mains, Kathryn, Siu, Albert, Gu, Jie, Zarzar, Jonathan, Yi, Li, Yuk, Inn H.
Published in Pharmaceutical research (01.03.2021)
Published in Pharmaceutical research (01.03.2021)
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Journal Article
Versatile LC–MS-Based Workflow with Robust 0.1 ppm Sensitivity for Identifying Residual HCPs in Biotherapeutic Products
Yang, Feng, Li, Delia, Kufer, Regina, Cadang, Lance, Zhang, Jennifer, Dai, Lu, Guo, Jia, Wohlrab, Stefanie, Greenwood-Goodwin, Midori, Shen, Amy, Duan, Dana, Li, Hong, Yuk, Inn H
Published in Analytical chemistry (Washington) (18.01.2022)
Published in Analytical chemistry (Washington) (18.01.2022)
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Journal Article
A fast and sensitive high-throughput assay to assess polysorbate-degrading hydrolytic activity in biopharmaceuticals
Gupta, Sanjay K., Graf, Tobias, Edelmann, Franziska T., Seelmann, Helen, Reintinger, Markus, Hillringhaus, Lars, Bergmann, Frank, Wiedmann, Michael, Falkenstein, Roberto, Wegele, Harald, Yuk, Inn H., Leiss, Michael
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2023)
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2023)
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Journal Article
A ribonucleoprotein‐based decaplex CRISPR/Cas9 knockout strategy for CHO host engineering
Carver, Joseph, Kern, Marie, Ko, Peggy, Greenwood‐Goodwin, Midori, Yu, X. Christopher, Duan, Dana, Tang, Danming, Misaghi, Shahram, Auslaender, Simon, Haley, Ben, Yuk, Inn H., Shen, Amy
Published in Biotechnology progress (01.01.2022)
Published in Biotechnology progress (01.01.2022)
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Journal Article
Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors
Hsu, Wei-Ting, Aulakh, Rigzen P. S., Traul, Donald L., Yuk, Inn H.
Published in Cytotechnology (Dordrecht) (01.12.2012)
Published in Cytotechnology (Dordrecht) (01.12.2012)
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Journal Article
Effects of copper on CHO cells: Cellular requirements and product quality considerations
Yuk, Inn H., Russell, Stephen, Tang, Yun, Hsu, Wei-Ting, Mauger, Jacob B., Aulakh, Rigzen P. S., Luo, Jun, Gawlitzek, Martin, Joly, John C.
Published in Biotechnology progress (01.01.2015)
Published in Biotechnology progress (01.01.2015)
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Journal Article
Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay
Yang, Yi, Mah, Anna, Yuk, Inn H., Grewal, Parbir S., Pynn, Abigail, Cole, Will, Gao, Di, Zhang, Fan, Chen, Jia, Gennaro, Lynn, Schöneich, Christian
Published in Journal of pharmaceutical sciences (01.10.2018)
Published in Journal of pharmaceutical sciences (01.10.2018)
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Journal Article
More similar than different: Host cell protein production using three null CHO cell lines
Yuk, Inn H., Nishihara, Julie, Walker Jr, Donald, Huang, Eric, Gunawan, Feny, Subramanian, Jayashree, Pynn, Abigail F.J., Yu, X.Christopher, Zhu-Shimoni, Judith, Vanderlaan, Martin, Krawitz, Denise C.
Published in Biotechnology and bioengineering (01.10.2015)
Published in Biotechnology and bioengineering (01.10.2015)
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Journal Article
Effects of copper on CHO cells: Insights from gene expression analyses
Yuk, Inn H., Zhang, Jitao David, Ebeling, Martin, Berrera, Marco, Gomez, Natalia, Werz, Silke, Meiringer, Christoph, Shao, Zhixin, Swanberg, Jeffrey C., Lee, Kelvin H., Luo, Jun, Szperalski, Berthold
Published in Biotechnology progress (01.03.2014)
Published in Biotechnology progress (01.03.2014)
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Journal Article
Controlling glycation of recombinant antibody in fed-batch cell cultures
Yuk, Inn H., Zhang, Boyan, Yang, Yi, Dutina, George, Leach, Kimberly D., Vijayasankaran, Natarajan, Shen, Amy Y., Andersen, Dana C., Snedecor, Bradley R., Joly, John C.
Published in Biotechnology and bioengineering (01.11.2011)
Published in Biotechnology and bioengineering (01.11.2011)
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Journal Article
A GFP-based screen for growth-arrested, recombinant protein-producing cells
Yuk, Inn H. Y., Wildt, Stefan, Jolicoeur, Mario, Wang, Daniel I. C., Stephanopoulos, Gregory
Published in Biotechnology and bioengineering (05.07.2002)
Published in Biotechnology and bioengineering (05.07.2002)
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Journal Article