Phase 0/microdosing approaches: time for mainstream application in drug development?
Burt, Tal, Young, Graeme, Lee, Wooin, Kusuhara, Hiroyuki, Langer, Oliver, Rowland, Malcolm, Sugiyama, Yuichi
Published in Nature reviews. Drug discovery (01.11.2020)
Published in Nature reviews. Drug discovery (01.11.2020)
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Journal Article
Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
KITAMURA, Satoshi, MAEDA, Kazuya, YI WANG, SUGIYAMA, Yuichi
Published in Drug metabolism and disposition (01.10.2008)
Published in Drug metabolism and disposition (01.10.2008)
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Journal Article
Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Journal Article
Experimental and Modeling Evidence Supporting the Trans -Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A
Izumi, Saki, Nozaki, Yoshitane, Lee, Wooin, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Journal Article
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions
Izumi, Saki, Nozaki, Yoshitane, Maeda, Kazuya, Komori, Takafumi, Takenaka, Osamu, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.02.2015)
Published in Drug metabolism and disposition (01.02.2015)
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Journal Article
Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium
Chu, Xiaoyan, Liao, Mingxiang, Shen, Hong, Yoshida, Kenta, Zur, Arik A, Arya, Vikram, Galetin, Aleksandra, Giacomini, Kathleen M, Hanna, Imad, Kusuhara, Hiroyuki, Lai, Yurong, Rodrigues, David, Sugiyama, Yuichi, Zamek-Gliszczynski, Maciej J, Zhang, Lei
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Journal Article
Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions
Lee, Wooin, Kim, Min-Soo, Kim, Jiyoung, Aoki, Yasunori, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.09.2023)
Published in Drug metabolism and disposition (01.09.2023)
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Journal Article
Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium
Yee, Sook Wah, Brackman, Deanna J, Ennis, Elizabeth A, Sugiyama, Yuichi, Kamdem, Landry K, Blanchard, Rebecca, Galetin, Aleksandra, Zhang, Lei, Giacomini, Kathleen M
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Journal Article
Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo
Miyauchi, Seiji, Kim, Soo-Jin, Lee, Wooin, Sugiyama, Yuichi
Published in Pharmacology & therapeutics (Oxford) (01.01.2022)
Published in Pharmacology & therapeutics (Oxford) (01.01.2022)
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Journal Article
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement
Aoki, Yasunori, Rowland, Malcom, Sugiyama, Yuichi
Published in Frontiers in pharmacology (25.07.2024)
Published in Frontiers in pharmacology (25.07.2024)
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