Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop, Dara, Weimer, Robby M., Lu, Yanmei, Kirkpatrick, Donald S., Ernst, James A., Chih, Ben, Dennis, Mark S., Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (06.01.2016)
Published in Neuron (Cambridge, Mass.) (06.01.2016)
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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Yu, Y Joy, Zhang, Yin, Kenrick, Margaret, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Atwal, Jasvinder, Elliott, J Michael, Prabhu, Saileta, Watts, Ryan J, Dennis, Mark S
Published in Science translational medicine (25.05.2011)
Published in Science translational medicine (25.05.2011)
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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Yu, Y Joy, Atwal, Jasvinder K, Zhang, Yin, Tong, Raymond K, Wildsmith, Kristin R, Tan, Christine, Bien-Ly, Nga, Hersom, Maria, Maloney, Janice A, Meilandt, William J, Bumbaca, Daniela, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Ernst, James A, Scearce-Levie, Kimberly, Couch, Jessica A, Dennis, Mark S, Watts, Ryan J
Published in Science translational medicine (05.11.2014)
Published in Science translational medicine (05.11.2014)
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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.
Published in The Journal of biological chemistry (03.03.2017)
Published in The Journal of biological chemistry (03.03.2017)
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
Couch, Jessica A, Yu, Y Joy, Zhang, Yin, Tarrant, Jacqueline M, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Tong, Raymond K, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Gadkar, Kapil, Prabhu, Saileta, Ordonia, Benjamin A, Nguyen, Quyen, Lin, Yuwen, Lin, Zhonghua, Balazs, Mercedesz, Scearce-Levie, Kimberly, Ernst, James A, Dennis, Mark S, Watts, Ryan J
Published in Science translational medicine (01.05.2013)
Published in Science translational medicine (01.05.2013)
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CD98hc is a target for brain delivery of biotherapeutics
Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Published in Nature communications (19.08.2023)
Published in Nature communications (19.08.2023)
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Fast Modulation of μ-Opioid Receptor (MOR) Recycling Is Mediated by Receptor Agonists
Roman-Vendrell, Cristina, Yu, Y. Joy, Yudowski, Guillermo Ariel
Published in The Journal of biological chemistry (27.04.2012)
Published in The Journal of biological chemistry (27.04.2012)
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Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development
Zaretsky, Serge, Adachi, Shinya, Rotstein, Benjamin H, Hickey, Jennifer L, Scully, Conor C. G, St. Denis, Jeffrey D, Courtemanche, Rebecca, Yu, Joy C. Y, Chung, Benjamin K. W, Yudin, Andrei K
Published in Journal of organic chemistry (07.11.2014)
Published in Journal of organic chemistry (07.11.2014)
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Author Correction: CD98hc is a target for brain delivery of biotherapeutics
Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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Twisted amide electrophiles enable cyclic peptide sequencing
Zaretsky, Serge, Rai, Vishal, Gish, Gerald, Forbes, Matthew W., Kofler, Michael, Yu, Joy C. Y., Tan, Joanne, Hickey, Jennifer L., Pawson, Tony, Yudin, Andrei K.
Published in Organic & biomolecular chemistry (21.07.2015)
Published in Organic & biomolecular chemistry (21.07.2015)
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Characterization of A Sensitive Mouse Aβ40 Pd Biomarker Assay for Alzheimer’s Disease Drug Development in Wild-Type Mice
Lu, Yanmei, Hoyte, Kwame, Montgomery, William H, Luk, Wilman, He, Dongping, Meilandt, William J, Zuchero, Y Joy Yu, Atwal, Jasvinder K, Scearce-Levie, Kimberly, Watts, Ryan J, DeForge, Laura E
Published in Bioanalysis (01.05.2016)
Published in Bioanalysis (01.05.2016)
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Soluble Dendron-Functionalized Carbon Nanotubes: Preparation, Characterization, and Properties
Sun, Ya-Ping, Huang, Weijie, Lin, Yi, Fu, Kefu, Kitaygorodskiy, Alex, Riddle, Lance A, Yu, Y. Joy, Carroll, David L
Published in Chemistry of materials (17.09.2001)
Published in Chemistry of materials (17.09.2001)
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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models
van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I, Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E, Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M, Beumers, Philipp, Capell, Anja, Davis, Sonnet S, de Weerd, Lis, Dugas, Jason C, Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T, Kunze, Lea H, Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O, Nguyen, Hoang N, Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H, Thorne, Robert G, Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y Joy Yu, Diaz, Dolo, Dennis, Mark S, Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J, Haass, Christian, Lewcock, Joseph W, Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E, Monroe, Kathryn M
Published in Nature neuroscience (01.03.2023)
Published in Nature neuroscience (01.03.2023)
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